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1.14.15.4: steroid 11beta-monooxygenase

This is an abbreviated version!
For detailed information about steroid 11beta-monooxygenase, go to the full flat file.

Word Map on EC 1.14.15.4

Reaction

A steroid
+ 2 reduced adrenodoxin +
O2
 + 2 H+ =
an 11beta-hydroxysteroid
 + 2 oxidized adrenodoxin +
H2O

Synonyms

11-hydroxylase, 11 beta-hydroxylase, 11-beta hydroxylase, 11-beta-hydroxylase, 11-hydroxylase, 11beta hydroxylase, 11beta-hydroxylase, ALDOS, Aldosterone synthase, Aldosterone-synthesizing enzyme, C450XIB2, CYP11B1, CYP11B2, cyp11beta, CYPXIB, CYPXIB1, CYPXIB2, CYPXIB3, cytochrome 11beta-hydroxylase, cytochrome P-45011-beta, cytochrome P450 11B1, cytochrome P450 11B2, cytochrome P450 11beta-hydroxylase, cytochrome P45011beta, cytochrome P45011beta-hydroxylase, EC 1.14.1.6, EC 1.99.1.7, P-450(11 beta,aldo), P-450Aldo, P-450c11, P-450C18, P-450XIB1, P450 11beta-hydroxylase, P450(11 beta)-DS, P45011beta, P450C11, Steroid 11-beta-hydroxylase, steroid 11-hydroxylase, steroid 11beta-hydroxylase, steroid 11beta-monooxygenase, steroid 11beta/18-hydroxylase, Steroid 18-hydroxylase, steroid-11beta-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.15.4 steroid 11beta-monooxygenase

IC50 Value

IC50 Value on EC 1.14.15.4 - steroid 11beta-monooxygenase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0000024
(1R)-2-[2-[(1S)-1-(4-chlorophenyl)ethyl]-3,3-dioxido-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazin-4-yl]-1-phenylethanol
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000003
(1S)-2-[2-[(1S)-1-(4-chlorophenyl)ethyl]-3,3-dioxido-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazin-4-yl]-1-phenylethanol
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000016 - 0.0000099
(R)-4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile
0.000448
1-(1H-inden-2-yl)-1H-imidazole
Homo sapiens
-
CYP11B2 IC50: 448 nM, no inhibition of CYP11B1, recombinant enzymes
0.000334 - 0.000639
1-(3,4-dihydronaphthalen-2-yl)-1H-imidazole
0.000143 - 0.000365
1-(3-bromobenzyl)-1H-imidazole
0.000151 - 0.000457
1-(3-chlorobenzyl)-1H-imidazole
0.001
1-(3-cyanobenzyl)-1H-imidazole
0.000206 - 0.000815
1-(3-fluorobenzyl)-1H-imidazole
0.000236 - 0.001
1-(4-aminobenzyl)-1H-imidazole
0.000211 - 0.000479
1-(4-bromobenzyl)-1H-imidazole
0.0000051 - 0.000007
1-(4-bromobenzyl)-5-phenyl-1H-imidazole
0.001
1-(4-chlorobenzyl)-1H-imidazole
0.0000058 - 0.000025
1-(4-chlorobenzyl)-5-phenyl-1H-imidazole
0.000368 - 0.000372
1-(4-cyanobenzyl)-1H-imidazole
0.0000023 - 0.00002
1-(4-cyanobenzyl)-5-(2-fluorophenyl)-1H-imidazole
0.0000037 - 0.0000057
1-(4-cyanobenzyl)-5-(2-methylphenyl)-1H-imidazole
0.0000055 - 0.000032
1-(4-cyanobenzyl)-5-(3-fluorophenyl)-1H-imidazole
0.0000052 - 0.0000062
1-(4-cyanobenzyl)-5-(3-methylphenyl)-1H-imidazole
0.000025 - 0.000027
1-(4-cyanobenzyl)-5-(4-fluorophenyl)-1H-imidazole
0.000117 - 0.00013
1-(4-cyanobenzyl)-5-(4-methylphenyl)-1H-imidazole
0.000307 - 0.000407
1-(4-cyanobenzyl)-5-(4-pyridyl)-1H-imidazole
0.000007 - 0.000048
1-(4-cyanobenzyl)-5-(methyl carboxylate)-1H-imidazole
0.000044 - 0.000213
1-(4-cyanobenzyl)-5-(methylene-acetate)-1H-imidazole
0.000023 - 0.000073
1-(4-cyanobenzyl)-5-bromo-1H-imidazole
0.000062 - 0.000478
1-(4-cyanobenzyl)-5-formyl-1H-imidazole
0.000029 - 0.000285
1-(4-cyanobenzyl)-5-hydroxymethyl-1H-imidazole
0.000012 - 0.000141
1-(4-cyanobenzyl)-5-methyl-1H-imidazole
0.0000017 - 0.000028
1-(4-cyanobenzyl)-5-phenyl-1H-imidazole
0.00033 - 0.001799
1-(4-fluorobenzyl)-1H-imidazole
0.000011 - 0.000016
1-(4-fluorobenzyl)-5-phenyl-1H-imidazole
0.000011 - 0.000014
1-(4-methoxybenzyl)-5-phenyl-1H-imidazole
0.000411 - 0.000763
1-(6-methoxy-3,4-dihydronaphthalen-2-yl)-1H-imidazole
0.0000048 - 0.000011
1-benzyl-5-phenyl-1H-imidazole
0.0000161 - 0.000166
2,4,5-trifluoro-N-(pyridin-3-yl)benzamide
0.0000052
2-(4-chlorobenzyl)-4-(2-methylpropyl)-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000186
2-benzyl-4-(2-methylpropyl)-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000094
2-[(1R)-1-(4-chlorophenyl)ethyl]-4-(2-methylpropyl)-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000617
2-[(1S)-1-(4-chlorophenyl)ethyl]-4-(2-methylpropyl)-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000007
2-[(1S)-1-(4-chlorophenyl)ethyl]-4-(3-methoxy-2-methylpropyl)-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000013
2-[(1S)-1-(4-chlorophenyl)ethyl]-4-(cyclopropylmethyl)-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000078
2-[(1S)-1-(4-chlorophenyl)ethyl]-4-[(3-methyloxetan-3-yl)methyl]-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000008
2-[(1S)-1-(4-chlorophenyl)ethyl]-4-[(propan-2-yloxy)methyl]-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000059 - 0.0000535
3,4-difluoro-N-(pyridin-3-yl)benzamide
0.000181 - 0.000286
3-(1-benzyl-1H-imidazol-5-yl)-1-propanol
0.00003 - 0.002117
3-(1-ethyl-3,4-dihydronaphthalen-2-yl)-pyridine
0.000007 - 0.001268
3-(1-methyl-3,4-dihydronaphthalen-2-yl)-pyridine
0.00039 - 0.0006
3-(1H-imidazol-1-ylmethyl)aniline
0.000007 - 0.001729
3-(3,4-dihydronaphthalen-2-yl)pyridine
0.000005 - 0.000503
3-(3-methyl-3,4-dihydronaphthalen-2-yl)pyridine
0.000176 - 0.001615
3-(4-ethyl-3,4-dihydronaphthalen-2-yl)pyridine
0.000013 - 0.001291
3-(4-methyl-3,4-dihydronaphthalen-2-yl)pyridine
0.000004 - 0.005684
3-(6-methoxy-1H-inden-2-yl)pyridine
0.000002 - 0.000578
3-(6-methoxy-3,4-dihydronaphthalen-2-yl)pyridine
0.000045
3-(7-methoxy-3,4-dihydronaphthalen-2-yl)pyridine
Homo sapiens
-
CYP11B2 IC50: 45 nM, no inhibition of CYP11B1, recombinant enzymes
0.000288 - 0.000735
3-[(Z)-2-phenylvinyl]pyridine
0.0000062 - 0.000018
3-[1-(4-bromobenzyl)-1H-imidazol-5-yl]-1-propanol
0.000044 - 0.000055
3-[1-(4-chlorobenzyl)-1H-imidazol-5-yl]-1-propanol
0.000013 - 0.000048
3-[1-(4-cyanobenzyl)-1H-imidazol-5-yl]-1-propanol
0.000016 - 0.000116
3-[1-(4-fluorobenzyl)-1H-imidazol-5-yl]-1-propanol
0.000012 - 0.000059
3-[1-(4-methoxybenzyl)-1H-imidazol-5-yl]-1-propanol
0.0000114
3-[2-[(1S)-1-(4-chlorophenyl)ethyl]-3,3-dioxido-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazin-4-yl]-2-methylpropan-1-ol
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.0000005 - 0.0000017
4-((5-phenyl-1H-imidazol-1-yl)methyl)benzonitrile
0.000117
4-(2-methylpropyl)-2-(thiophen-2-ylmethyl)-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000104
4-(2-methylpropyl)-2-[4-(trifluoromethoxy)benzyl]-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.000121
4-(2-methylpropyl)-2-[4-(trifluoromethyl)benzyl]-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide
Homo sapiens
-
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication
0.002529 - 0.002834
4-(6-methoxy-3,4-dihydronaphthalen-2-yl)pyridine
0.000104 - 0.000167
4-bromo-N-(pyridin-3-yl)benzamide
0.0000102 - 0.000065
4-chloro-N-(pyridin-3-yl)benzamide
0.0000075 - 0.000078
4-cyano-N-(pyridin-3-yl)benzamide
0.0000143 - 0.000082
4-fluoro-N-(pyridin-3-yl)benzamide
0.0000248 - 0.000145
4-nitro-N-(pyridin-3-yl)benzamide
0.0000002 - 0.000033
6-(5,8-dihydroisoquinolin-4-yl)-3,4-dihydroquinolin-2(1H)-one
0.000089 - 0.002077
8-(1H-imidazol-1-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.000001 - 0.000158
8-(5-ethoxypyridin-3-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.0000044 - 0.001288
8-(5-fluoropyridin-3-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.0000043 - 0.002045
8-(5-hydroxypyridin-3-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.0000006 - 0.000247
8-(5-methoxypyridin-3-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.0000013 - 0.000058
8-(5-phenylpyridin-3-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]-quinolin-4-one
0.0000002 - 0.000013
8-(isoquinolin-4-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.0000011 - 0.000715
8-(pyridin-3-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.0000012 - 0.000333
8-(pyridin-3-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinoline-4-thione
0.000056 - 0.02855
8-(pyrimidin-5-yl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.0000036 - 0.000183
8-[5-(2,5-difluorophenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.0000007 - 0.000043
8-[5-(2-fluorophenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.0000024 - 0.000128
8-[5-(2-methoxyphenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.0000023 - 0.000496
8-[5-(3,4-difluorophenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.000018 - 0.001748
8-[5-(3,5-difluorophenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.0000014 - 0.00049
8-[5-(3-fluorophenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.0000012 - 0.000044
8-[5-(3-hydroxyphenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.0000046 - 0.001374
8-[5-(3-methoxyphenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.0000009 - 0.00004
8-[5-(4-fluorophenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.0000014 - 0.000021
8-[5-(4-methoxyphenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.0000022 - 0.000103
8-[5-(propan-2-yloxy)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.0000059 - 0.000141
8-[5-(trifluoromethyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.000016 - 0.002058
8-[5-[3-(trifluoromethoxy)phenyl]pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.000033 - 0.004646
8-[5-[3-(trifluoromethyl)phenyl]pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
0.0000009 - 0.000545
9-(5-methoxypyridin-3-yl)-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-5-one
0.0000024 - 0.002296
9-(pyridin-3-yl)-1,2,6,7-tetrahydro-5H-pyrido[ 3,2,1-ij]quinolin-3-one
0.0000002 - 0.000034
9-[6-(isoquinolin-4-yl)pyridin-3-yl]-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-5-one
0.000001 - 0.00001
fadrozole
0.000081 - 0.000224
ketoconazole
0.000193 - 0.000326
methyl 3-(1-benzyl-1H-imidazol-5-yl)-propanoate
0.000004 - 0.000057
methyl 3-[1-(4-bromobenzyl)-1H-imidazol-5-yl]-propanoate
0.000123 - 0.000177
methyl 3-[1-(4-chlorobenzyl)-1H-imidazol-5-yl]-propanoate
0.0000035 - 0.000031
methyl 3-[1-(4-cyanobenzyl)-1H-imidazol-5-yl]-propanoate
0.00005 - 0.000104
methyl 3-[1-(4-fluorobenzyl)-1H-imidazol-5-yl]-propanoate
0.000111 - 0.000121
methyl 3-[1-(4-methoxybenzyl)-1H-imidazol-5-yl]-propanoate
0.0000146 - 0.000072
Metyrapone
0.000006 - 0.000119
R-fadrozole
0.00004 - 0.000171
S-fadrozole
0.000206 - 0.001174
[3-(1H-imidazol-1-ylmethyl)phenyl]methanol
0.000695 - 0.001
[4-(1H-imidazol-1-ylmethyl)phenyl]methanol
0.0001
additional information
Homo sapiens
-
development and analysis of inhibitory potency of diverse inhibitors by superimposition of active and non-active compounds, modelling based on two pyridyl substituted acenaphthene derivatives, IC50 values of good inhibitors below 100 nM and of weak inhibi
-