1.2.1.100: 5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase

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For detailed information about 5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase, go to the full flat file.

Reaction

5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate

3-hydroxy-2-methylpyridine-4,5-dicarboxylate

Synonyms

mlr6739, mlr6793

ECTree

1 Oxidoreductases

1.2 Acting on the aldehyde or oxo group of donors

1.2.1 With NAD⁺ or NADP⁺ as acceptor

1.2.1.100 5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase

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Results	in table
2	AA Sequence
1	Cloned(Commentary)
1	Crystallization (Commentary)
1	Expression
2	General Information
6	KM Value [mM]
2	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
5	Organism
3	Pathway
3	pH Optimum
4	Protein Variants
1	Reaction
4	Reference
8	Substrates and Products (Substrate)
3	Subunits
4	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
3	Turnover Number [1/s]

Engineering

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Engineering on EC 1.2.1.100 - 5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase

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Go to Protein Variants Search

E149Q

Mesorhizobium loti

Q988H5

mutant shows a showed a different pH optimum depending on the cosubstrate. With NAD+, the mutant shows very low activity with an optimum pH at 8.5 in the universal buffer. In contrast, the optimum pH is 5.5 with NADH

745236

H137L