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1.2.1.103: [amino group carrier protein]-6-phospho-L-2-aminoadipate reductase

This is an abbreviated version!
For detailed information about [amino group carrier protein]-6-phospho-L-2-aminoadipate reductase, go to the full flat file.

Reaction

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an [amino group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine
+
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phosphate
+
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NADP+
=
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an [amino group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine
+
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NADPH
+
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H+

Synonyms

lysY

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                EC 1.2.1.1031.2.1.103 [amino group carrier protein]-6-phospho-L-2-aminoadipate reductase

Engineering

Engineering on EC 1.2.1.103 - [amino group carrier protein]-6-phospho-L-2-aminoadipate reductase

for references in articles please use BRENDA:EC1.2.1.103

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
H209A
the mutant exhibits similar activity to that of the wildtype enzyme
K271A
the mutation results in a 4.6fold decrease in kcat and a 70fold increase in Km value compared to the wild type enzyme
R195A
the mutation results in a 5fold decrease in kcat and a 40fold increase in Km value compared to the wild type enzyme
R258A
the mutation results in a slight decrease in kcat and a 17fold increase in Km value compared to the wild type enzyme