1.2.1.104: pyruvate dehydrogenase system This is an abbreviated version! For detailed information about pyruvate dehydrogenase system, go to the full flat file .
Reaction
pyruvate +
CoA +
NAD+ =
acetyl-CoA +
CO2 +
NADH
Synonyms aceE, AceF, At1g54220, At3g13930, At3g52200, CTHT_0006350, CTHT_0069820, dihydrolipoamide acetyltransferase, dihydrolipoyllysine-residue acetyltransferase component, DLAT, DLD, DLST, E1 component of pyruvate dehydrogenase complex, E1 component subunit alpha, E1 component subunit beta, IAR4, LpdA, Lta3, MAB1, More, Mrp-3, Pda1, Pda1p, PDC, PDCp, PDH, PDH complex, PDH-E1 catalytic subunit, PDHa, PdhA1, PDHalpha, PdhB1, PDHC, PdhE, PDHE1alpha1, PdhH, PdhX, PH2, plastidial pyruvate dehydrogenase complex, pyruvate decarboxylase, pyruvate dehydrogenase, pyruvate dehydrogenase alpha subunit, pyruvate dehydrogenase complex, pyruvate dehydrogenase E1
ECTree
Cofactor
Cofactor on EC 1.2.1.104 - pyruvate dehydrogenase system
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additional information
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CoA and NAD+ required by pyruvate dehydrogenase complex
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CoA
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NAD+
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NADH
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thiamine diphosphate
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thiamine diphosphate
Pigeon
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thiamine diphosphate
Hansenula miso
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thiamine diphosphate
Pigeon
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two binding sites
thiamine diphosphate
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Km value 0.0034 mM for overall reaction
thiamine diphosphate
only one of the two thiamine molecules bound to the two active sites of the alpha2beta2 E1 component is in a chemically activated state exhibiting an apparent C2 ionization rate constant of approximately 50 per s at pH 7.6 and 30°C, whereas the thiamine in the inactive site ionizes with a rate that is at least 3 orders of magnitude smaller