1.2.1.104: pyruvate dehydrogenase system
This is an abbreviated version!
For detailed information about pyruvate dehydrogenase system, go to the full flat file.
Reaction
Synonyms
aceE, AceF, At1g54220, At3g13930, At3g52200, CTHT_0006350, CTHT_0069820, dihydrolipoamide acetyltransferase, dihydrolipoyllysine-residue acetyltransferase component, DLAT, DLD, DLST, E1 component of pyruvate dehydrogenase complex, E1 component subunit alpha, E1 component subunit beta, IAR4, LpdA, Lta3, MAB1, More, Mrp-3, Pda1, Pda1p, PDC, PDCp, PDH, PDH complex, PDH-E1 catalytic subunit, PDHa, PdhA1, PDHalpha, PdhB1, PDHC, PdhE, PDHE1alpha1, PdhH, PdhX, PH2, plastidial pyruvate dehydrogenase complex, pyruvate decarboxylase, pyruvate dehydrogenase, pyruvate dehydrogenase alpha subunit, pyruvate dehydrogenase complex, pyruvate dehydrogenase E1
ECTree
1.2.1.104 pyruvate dehydrogenase systemAdvanced search results
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results (Substrates Products
Substrates Products on EC 1.2.1.104 - pyruvate dehydrogenase system
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
hydroxyethyl thiamine diphosphate + CoA + NAD+
? + NADH
-
-
-
-
?
pyruvate + CoA + dichlorophenol indophenol
acetyl-CoA + CO2 + ?
-
-
-
?
pyruvate + CoA + ferricyanide
acetyl-CoA + CO2 + ferrocyanide
-
-
-
?
pyruvate + CoA + oxidized 2,6-dichlorophenolindophenol
acetyl-CoA + CO2 + reduced 2,6-dichlorophenolindophenol
pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine
[dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
-
-
-
?
pyruvate + CoA + NAD+
acetyl-CoA + CO2 + NADH
-
-
-
-
?
pyruvate + CoA + NAD+
acetyl-CoA + CO2 + NADH
-
-
-
-
?
pyruvate + CoA + oxidized 2,6-dichlorophenolindophenol
acetyl-CoA + CO2 + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
pyruvate + CoA + oxidized 2,6-dichlorophenolindophenol
acetyl-CoA + CO2 + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
-
additional reactions of complex, e. g. reduction of K3Fe(CN)6
-
?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
-
in overall reaction of pyruvate dehydrogenase complex, pyruvate can be replaced by 2-ketobutyrate
-
?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
-
in overall reaction of pyruvate dehydrogenase complex, pyruvate can be replaced by 2-ketobutyrate
-
?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
-
additional reactions of complex, e. g. reduction of K3Fe(CN)6
-
?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
Hansenula miso
-
in overall reaction of pyruvate dehydrogenase complex, pyruvate can be replaced by 2-ketobutyrate
-
-
?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
Hansenula miso
-
low reactivity with 2-ketovalerate
-
-
?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
Hansenula miso
-
additional reactions of complex, e. g. reduction of K3Fe(CN)6
-
-
?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
-
in overall reaction of pyruvate dehydrogenase complex, pyruvate can be replaced by 2-ketobutyrate
-
?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
-
additional reactions of complex, e. g. reduction of K3Fe(CN)6
-
?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
-
in overall reaction of pyruvate dehydrogenase complex, pyruvate can be replaced by hydroxypyruvate
-
?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
-
-
-
-
?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
-
in overall reaction of pyruvate dehydrogenase complex, pyruvate can be replaced by hydroxypyruvate
-
?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
-
in overall reaction of pyruvate dehydrogenase complex, pyruvate can be replaced by hydroxypyruvate
-
?
additional information
?
-
non-complex-bound E1p shows the same cooperativity as found for complex-bound E1p. A Hill coefficient of 1.2-1.6 is calculated for non-complex bound E1p
-
-
-
additional information
?
-
-
E1 is bound to E2, both components of the pyruvate dehydrogenase multienzyme complex PDC, via the E1-binding B domain of E2, enzyme component organization in the pyruvate dehydrogenase multienzyme complex, regulatory role, overview
-
-
?
additional information
?
-
-
the PDH complex irreversibly decarboxylates pyruvate to acetylCoA (PDH activity) in a reaction that involves the participation of the three enzymes forming the PDH complex: AceE (pyruvate decarboxylase), AceF (dihydrolipoil acetyltransferase) and Lpd (dihydrolipoil dehydrogenase)
-
-
?
additional information
?
-
-
the PDH complex irreversibly decarboxylates pyruvate to acetylCoA (PDH activity) in a reaction that involves the participation of the three enzymes forming the PDH complex: AceE (pyruvate decarboxylase), AceF (dihydrolipoil acetyltransferase) and Lpd (dihydrolipoil dehydrogenase)
-
-
?
additional information
?
-
-
in vivo there are 20-30 E1 molecules bound to each core of the mammalian PDC, the small binding domain of E2 in humans binds only to E1
-
-
?
additional information
?
-
-
the pyruvate dehydrogenase complex consists of multiple copies of several components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2), dihydrolipoamide dehydrogenase (E3), E3-binding protein (BP), and specific kinases and phosphatases
-
-
?
additional information
?
-
pyruvate is a better substrate than 2-oxobutanoate, other 2-oxo-acids are not substrates
-
-
-
additional information
?
-
-
substrate interaction kinetics for all substrates are consistent with a multisite ping-pong mechanism
-
-
-
additional information
?
-
-
pyruvate-supported mitochondrial respiration state 3
-
-
?
additional information
?
-
-
substrate interaction kinetics for all substrates are consistent with a multisite ping-pong mechanism
-
-
-
additional information
?
-
-
regulation of pyruvate dehydrogenase complex activity and citric acid cycle intermediates during high cardiac power generation, inhibition of fatty acid oxidation has a regulatory function, overview
-
-
?
