1.2.1.105: 2-oxoglutarate dehydrogenase system
This is an abbreviated version!
For detailed information about 2-oxoglutarate dehydrogenase system, go to the full flat file.
Word Map on EC 1.2.1.105
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1.2.1.105
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kgdhc
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dihydrolipoamide
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thiamin
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alpha-ketoacids
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2-oxoadipate
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transsuccinylase
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charcot-marie-tooth
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2-aminoadipic
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medicine
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thiokinase
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glutaryl-coa
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analysis
- 1.2.1.105
- kgdhc
- dihydrolipoamide
- thiamin
- alpha-ketoacids
- 2-oxoadipate
-
transsuccinylase
- charcot-marie-tooth
-
2-aminoadipic
- medicine
- thiokinase
- glutaryl-coa
- analysis
Reaction
Synonyms
2-OGDH2, 2-oxoglutarate dehydrogenase, 2-oxoglutarate dehydrogenase complex, alpha-KDE2, alpha-ketoglutarate dehydrogenase, alpha-ketoglutarate dehydrogenase complex, alpha-KGDH, At3g55410, At5g65750, DHTKD1, dihydrolipoyl succinyltransferase E2, E1a, E1k, E1o, E2, KGDH, KGDHC, More, MPA24.10, ODGH, ODGH1, ODGH2, ODH, OGDC, OGDH, OGDHC, OGDHL, OGHDC-E2, PDHC, SucA, SucB
ECTree
1.2.1.105 2-oxoglutarate dehydrogenase systemAdvanced search results
results (
results (Source Tissue
Source Tissue on EC 1.2.1.105 - 2-oxoglutarate dehydrogenase system
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
guard cell-enriched epidermal fragments, higher expression levels of isoform 2-OGDH1 than isoform 2-OGDH2
isoform E1-OGDH2 is slightly more expressed in cauline leaf and flowers
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The HEK-293 subline E2k-67 shows about 30% reduced KGDHC activity; control line E2k-100
young, mature, senescent leaves, lesaf blade and midrib, show higher expression levels of isoform 2-OGDH1 than isoform 2-OGDH2. Isoform E1-OGDH2 is slightly more expressed in cauline leaf and flowers
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highest activity found in rapidly growing mycelium, glucose-NH4+ or glucose-peptone medium
higher expression levels of isoform 2-OGDH1 than isoform 2-OGDH2
additional information
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neurons that appear slectively vulnerable in human temporal cortex in Alzheimer's disease are enriched in the 2-oxoglutarate dehydrogenase complex
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endothelial cells have about six times higher activity than do brain microglial cells or neurons
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diminished activities in regions with severe pathology, as well as in areas of minimal pathology, activity declines with the severity of disease
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overall reaction activities of the PDH and OGDH complexes are very high, in order of heart > abdominal skeletal muscle > kidney. Their gene expression is strongest in heart and skeletal muscle
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348910, 348914, 349005, 349014, 349020, 349021, 349023, 349026, 349027, 349028, 349033, 656591, 672280, 676088, 676319, 758747, 759437, 759561
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overall reaction activities of the PDH and OGDH complexes are very high, in order of heart > abdominal skeletal muscle > kidney. Their gene expression is strongest in heart and skeletal muscle
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overall reaction activities of the PDH and OGDH complexes are very high, in order of heart > abdominal skeletal muscle > kidney. Their gene expression is strongest in heart and skeletal muscle
additional information
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tenfold increase in 2-oxoglutarate dehydrogenase complex activity between the amoeba stage and the aggregation stage, 2fold increase between the aggregation stage and the sorocarp stage
