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1.2.1.105: 2-oxoglutarate dehydrogenase system

This is an abbreviated version!
For detailed information about 2-oxoglutarate dehydrogenase system, go to the full flat file.

Word Map on EC 1.2.1.105

Reaction

2-oxoglutarate
+
CoA
+
NAD+
=
succinyl-CoA
+
CO2
+
NADH

Synonyms

2-OGDH2, 2-oxoglutarate dehydrogenase, 2-oxoglutarate dehydrogenase complex, alpha-KDE2, alpha-ketoglutarate dehydrogenase, alpha-ketoglutarate dehydrogenase complex, alpha-KGDH, At3g55410, At5g65750, DHTKD1, dihydrolipoyl succinyltransferase E2, E1a, E1k, E1o, E2, KGDH, KGDHC, More, MPA24.10, ODGH, ODGH1, ODGH2, ODH, OGDC, OGDH, OGDHC, OGDHL, OGHDC-E2, PDHC, SucA, SucB

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.105 2-oxoglutarate dehydrogenase system

Substrates Products

Substrates Products on EC 1.2.1.105 - 2-oxoglutarate dehydrogenase system

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-oxoadipate + CoA + NAD+
glutaryl-CoA + CO2 + NADH
show the reaction diagram
2-oxoadipate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
[dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine + CO2
show the reaction diagram
2-oxoglutarate + CoA + 3-acetylpyridine adenine dinucleotide
succinyl-CoA + CO2 + reduced 3-acetylpyridine adenine dinucleotide
show the reaction diagram
2-oxoglutarate + CoA + NAD+
succinyl-CoA + CO2 + NADH
show the reaction diagram
2-oxoglutarate + CoA + NAD+
succinyl-CoA + CO2 + NADH + H+
show the reaction diagram
-
-
-
-
?
2-oxoglutarate + lipoamide
S-succinyldihydrolipoamide + CO2
show the reaction diagram
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
show the reaction diagram
2-oxovalerate + CoA + NAD+
? + CO2 + NADH
show the reaction diagram
unnatural substrate, very poor substrate of wild-type
-
-
?
additional information
?
-