1.2.1.107: glyceraldehyde-3-phosphate dehydrogenase (arsenate-transferring)

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For detailed information about glyceraldehyde-3-phosphate dehydrogenase (arsenate-transferring), go to the full flat file.

Reaction

Synonyms

acylglyceraldehyde-3-phosphate dehydrogenase, AsV reductase, D-glyceraldehyde-3-phosphate dehydrogenase, FA-GPDH, G3P dehydrogenase, G3PD, G3PDH, GAPDH, glyceraldehyde-3-P dehydrogenase, GPD, [beta-(2-furyl)acryloyl]glyceraldehyde-3-phosphate dehydrogenase

ECTree

1 Oxidoreductases

1.2 Acting on the aldehyde or oxo group of donors

1.2.1 With NAD⁺ or NADP⁺ as acceptor

1.2.1.107 glyceraldehyde-3-phosphate dehydrogenase (arsenate-transferring)

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Results	in table
4	Activating Compound
1	AA Sequence
4	Cloned(Commentary)
17	Cofactor
1	Crystallization (Commentary)
1	General Stability
17	Inhibitors
2	Ki Value [mM]
8	KM Value [mM]
9	Localization
3	Metals/Ions
3	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
18	Organism
1	Pathway
5	pH Optimum
2	pH Range
1	pI Value
1	Protein Variants
6	Purification (Commentary)
1	Reaction
18	Reference
19	Source Tissue
3	Specific Activity [micromol/min/mg]
1	Storage Stability
19	Substrates and Products (Substrate)
5	Subunits
22	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.2.1.107 - glyceraldehyde-3-phosphate dehydrogenase (arsenate-transferring)

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D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (arsenate-transferring)

The enzyme, discovered in bacteria, is very similar to EC 1.2.1.12, glyceraldehyde-3-phosphate dehydrogenase (phosphorylating). However, the gene encoding it is located in arsenic resistance islands in the chromosome, next to a gene (arsJ) that encodes a transporter that removes the product, 1-arsono-3-phosphoglycerate, from the cell. Together the two proteins form an arsenic detoxification system.