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1.2.1.15: malonate-semialdehyde dehydrogenase

This is an abbreviated version!
For detailed information about malonate-semialdehyde dehydrogenase, go to the full flat file.

Reaction

3-oxopropanoate
+
NAD(P)+
+
H2O
=
malonate
+
NAD(P)H
+
H+

Synonyms

dehydrogenase, malonate semialdehyde, IolA, KES23460, NAD-dependent malonate-semialdehyde dehydrogenase

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.15 malonate-semialdehyde dehydrogenase

Substrates Products

Substrates Products on EC 1.2.1.15 - malonate-semialdehyde dehydrogenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3-oxopropanoate + NAD+ + H2O
malonate + NADH
show the reaction diagram
-
-
-
-
?
malonic semialdehyde + NAD+
acetyl-CoA + NADH + CO2
show the reaction diagram
-
-
-
-
?
NAD(P)+ + 3-oxopropanoate + H2O
malonate + NAD(P)H
show the reaction diagram
-
-
-
ir
additional information
?
-
-
no activity with formaldehyde, acetaldehyde, propionaldehyde, isovaleraldehyde, benzaldehyde, anisaldehyde, glyceraldehyde, glyceraldehyde-3-phosphate, glyoxylate, succinic semialdehyde
-
-
?