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1.2.1.18: malonate-semialdehyde dehydrogenase (acetylating)

This is an abbreviated version!
For detailed information about malonate-semialdehyde dehydrogenase (acetylating), go to the full flat file.

Reaction

3-oxopropanoate
+
CoA
+
NAD(P)+
=
acetyl-CoA
+
CO2
+
NAD(P)H
+
H+

Synonyms

Aldh6a1, dehydrogenase, malonate semialdehyde, FG99_15390, KES23460, malonate semialdehyde oxidative decarboxylase, malonate-semialdehyde dehydrogenase, malonate-semialdehyde dehydrogenase (NADP+) (acylating), malonate-semialdehyde: nicotinamide adenine dinucleotide oxidoreductase, malonic semialdehyde oxidative decarboxylase, methylmalonate-semialdehyde dehydrogenase, NAD-dependent malonate-semialdehyde dehydrogenase

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.18 malonate-semialdehyde dehydrogenase (acetylating)

Reference

Reference on EC 1.2.1.18 - malonate-semialdehyde dehydrogenase (acetylating)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Goodwin, G.W.; Rougraff, P.M.; Davis, E.J.; Harris, R.A.
Purification and characterization of methylmalonate-semialdehyde dehydrogenase from rat liver. Identity to malonate-semialdehyde dehydrogenase
J. Biol. Chem.
264
14965-14971
1989
Rattus norvegicus
Manually annotated by BRENDA team
Waters, P.; Venables, W.A.
A complete pathway for beta-alanine and beta-amino-iso-butyrate catabolism in Pseudomonas aeruginosa
FEMS Microbiol. Lett.
34
279-282
1986
Pseudomonas aeruginosa
-
Manually annotated by BRENDA team
Maentsaelae, P.; Pirttikoski, M.; Numikko, V.
Formation of malonate-semialdehyde: nicotinamide adenine dinucleotide (NAD) oxidoreductase in Pseudomonas fluorescens P-2
Acta Chem. Scand.
1
395-396
1972
Pseudomonas fluorescens
-
Manually annotated by BRENDA team
Jakoby, W.B.
Aldehyde dehydrogenase
The Enzymes, 2nd Ed. (Boyer, P. D. , Lardy, H. , Myrbäck, K. , eds. )
7
203-221
1963
Pseudomonas sp.
-
Manually annotated by BRENDA team
Hayaishi, O.; Nishizuka, Y.; Tatibana, M.; Takeshita, M.; Kuno, S.
Enzymatic studies on the metabolism of beta-alanine
J. Biol. Chem.
236
781-790
1961
Pseudomonas fluorescens
Manually annotated by BRENDA team
Yamada, E.W.; Jakoby, W.B.
Aldehyde oxidation
J. Biol. Chem.
235
589-594
1960
Pseudomonas fluorescens
Manually annotated by BRENDA team
Strauss, G.; Fuchs, G.
Enzymes of a novel autotrophic carbon dioxide fixation pathway in the phototrophic bacterium Chloroflexus aurantiacus, the 3-hydroxypropionate cycle
Eur. J. Biochem.
215
633-643
1993
Chloroflexus aurantiacus
Manually annotated by BRENDA team
Marchitti, S.A.; Deitrich, R.A.; Vasiliou, V.
Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase
Pharmacol. Rev.
59
125-150
2007
Homo sapiens (Q02252)
Manually annotated by BRENDA team
Alnouti, Y.; Klaassen, C.D.
Tissue distribution, ontogeny, and regulation of aldehyde dehydrogenase (Aldh) enzymes mRNA by prototypical microsomal enzyme inducers in mice
Toxicol. Sci.
101
51-64
2008
Mus musculus (Q9EQ20)
Manually annotated by BRENDA team
Wilding, M.; Scott, C.; Peat, T.S.; Newman, J.
X-ray crystal structure of a malonate-semialdehyde dehydrogenase from Pseudomonas sp. strain AAC
Acta Crystallogr. Sect. F
73
24-28
2017
Pseudomonas sp., Pseudomonas sp. AAC
Manually annotated by BRENDA team