1.2.1.22: lactaldehyde dehydrogenase

This is an abbreviated version!
For detailed information about lactaldehyde dehydrogenase, go to the full flat file.

Reaction

Synonyms

ALD, AldA, aldehyde dehyrogenase, ALDH, AN0544, AvLADH, dehydrogenase, lactaldehyde, L-lactaldehyde dehydrogenase, L-lactaldehyde:NAD oxidoreductase, Lactaldehyde dehydrogenase, LADH, MJ1411, More, NAD-dependent lactaldehyde dehydrogenase, nicotinamide adenine dinucleotide (NAD)-linked dehydrogenase, PsLADH, SSO3117

ECTree

     1 Oxidoreductases

         1.2 Acting on the aldehyde or oxo group of donors

             1.2.1 With NAD⁺ or NADP⁺ as acceptor

                1.2.1.22 lactaldehyde dehydrogenase

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Results	in table
4	Activating Compound
1351	AA Sequence
1	CAS Registry Number
9	Cloned(Commentary)
25	Cofactor
2	Crystallization (Commentary)
2	Expression
13	General Information
2	General Stability
22	Inhibitors
4	kcat/KM [mM/s]
29	KM Value [mM]
1	Localization
4	Metals/Ions
10	Molecular Weight [Da]
24	Natural Substrates/ Products (Substrates)
35	Organism
9	Pathway
18	PDB ID
5	pH Optimum
2	pH Range
1	pH Stability
26	Protein Variants
13	Purification (Commentary)
1	Reaction
3	Reaction Type
30	Reference
9	Source Tissue
28	Specific Activity [micromol/min/mg]
2	Storage Stability
82	Substrates and Products (Substrate)
6	Subunits
80	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Range [°C]
6	Temperature Stability [°C]
11	Turnover Number [1/s]

Crystallization

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Crystallization on EC 1.2.1.22 - lactaldehyde dehydrogenase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

by the hanging-drop, vapor-diffusion method. Serendipitous crystal structure of unliganded lactaldehyde dehydrogenase determined by multiple isomorphous replacement using anomalous scattering, at 2.2 A resolution. Crystal structure of the ternary enzyme complex with products lactate and NADH at 2.1 A resolution, and binary complex complex with NADPH at 2.7 A resolution. The ternary complex reveals that the nicotinamide ring of NADH occupies two distinct conformations, one with the ring positioned in the active site in the so-called hydrolysis conformation and another with the ring extended out of the active site into the solvent region

Escherichia coli

P25553

675430

in complex with NADH and lactate

Escherichia coli

P25553

675430