1.2.1.23: 2-oxoaldehyde dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about 2-oxoaldehyde dehydrogenase (NAD+), go to the full flat file.

Reaction

Synonyms

2-ketoaldehyde dehydrogenase, ADH1, alpha-ketoaldehyde dehydrogenase, methylglyoxal dehydrogenase, MGD, NAD+-linked alcohol dehydrogenase 1, NAD+-linked methylglyoxal dehydrogenase, NAD-dependent alpha-ketoaldehyde dehydrogenase, NAD-linked alpha-ketoaldehyde dehydrogenase

ECTree

     1 Oxidoreductases

         1.2 Acting on the aldehyde or oxo group of donors

             1.2.1 With NAD⁺ or NADP⁺ as acceptor

                1.2.1.23 2-oxoaldehyde dehydrogenase (NAD+)

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Results	in table
18	Activating Compound
1	AA Sequence
3	CAS Registry Number
2	Cloned(Commentary)
22	Cofactor
1	Expression
2	General Information
38	Inhibitors
2	kcat/KM [mM/s]
38	KM Value [mM]
3	Metals/Ions
6	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
14	Organism
3	Pathway
4	pH Optimum
4	pH Range
1	Protein Variants
7	Purification (Commentary)
1	Reaction
3	Reaction Type
14	Reference
15	Source Tissue
9	Specific Activity [micromol/min/mg]
2	Storage Stability
40	Substrates and Products (Substrate)
4	Subunits
10	Synonyms
1	Systematic Name
2	Turnover Number [1/s]

General Information

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General Information on EC 1.2.1.23 - 2-oxoaldehyde dehydrogenase (NAD+)

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

malfunction

Candida albicans

A0A1D8PP43

methylglyoxal accumulation leads to G2-phase arrest by affecting cell growth, ROS production, viability, differentiation, and virulence. Phenotypes of enzyme-deficient cells, overview

742509

physiological function

Candida albicans

A0A1D8PP43

the enzyme catalyzes both methylglyoxal oxidation to pyruvate as well as its reduction to acetol. ADH1 activity likely shifts between methylglyoxal oxidation and reduction with a marked change in the intracellular redox state during the growth, such as GSH starvation. The enzyme is required for regulation of methylglyoxal content in the cell. Mgd activity is highly induced in GSH-deficient cells

742509