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1.2.1.23: 2-oxoaldehyde dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about 2-oxoaldehyde dehydrogenase (NAD+), go to the full flat file.

Word Map on EC 1.2.1.23

Reaction

a 2-oxoaldehyde
+
NAD+
 +
H2O
=
a 2-oxo carboxylate
 +
NADH
 +
H+

Synonyms

2-ketoaldehyde dehydrogenase, ADH1, alpha-ketoaldehyde dehydrogenase, methylglyoxal dehydrogenase, MGD, NAD+-linked alcohol dehydrogenase 1, NAD+-linked methylglyoxal dehydrogenase, NAD-dependent alpha-ketoaldehyde dehydrogenase, NAD-linked alpha-ketoaldehyde dehydrogenase

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.23 2-oxoaldehyde dehydrogenase (NAD+)

Inhibitors

Inhibitors on EC 1.2.1.23 - 2-oxoaldehyde dehydrogenase (NAD+)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3',5'-cyclic AMP
-
weak inhibition
5,5'-dithiobis(2-nitrobenzoate)
-
-
AMP
-
weak inhibition
ATP
-
strong inhibitor, 0.6 mM
barbiturates
-
Co2+
-
30-40% inhibition at 1.0 mM
Cu2+
-
30-40% inhibition at 1.0 mM
cyanide
-
-
diethanolamine
-
causes 40% inhibition of the enzyme activated by L-2-aminopropan-1-ol at a concentration of 50 mM
EDTA
-
60% inhibition at 5 mM, 87% inhibition at 10 mM
glyceraldehyde 3-phosphate
-
strong inhibitor
glycine buffer
-
complete blockage of the reaction
GTP
-
strong inhibitor, 1 mM
Hg2+
-
almost complete inhibition at 1 mM HgCl2
hydrazine
-
1-3 mM
hydroxylamine
-
1-3 mM
Mn2+
-
30-40% inhibition at 1.0 mM
N-ethylmaleimide
N-tris(hydroxymethyl)methylglycine
-
-
NADP+
Ni2+
-
30-40% inhibition at 1.0 mM
Nitro-alcohols
-
analogues of the activating amines, at large concentrations, 66-83 mM
-
oxalate
-
60% inhibition at 5 mM, 96% inhibition at 10 mM
p-chloromercuribenzoate
p-hydroxymercuribenzoate
-
1-3 mM
phosphate
-
inhibits the enzyme prepared from the acetone-dried liver extract, 10-20 mM
Semicarbazide
-
1-3 mM
Sodium bisulfite
-
1 mM
Tris(hydroxymethyl)nitromethane
-
50% inhibition at a concentration of 139 mM