1.2.1.27: methylmalonate-semialdehyde dehydrogenase (CoA-acylating)

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For detailed information about methylmalonate-semialdehyde dehydrogenase (CoA-acylating), go to the full flat file.

Word Map on EC 1.2.1.27

Reaction

2-Methyl-3-oxopropanoate
+
CoA
+
H2O
+
NAD+
=
propanoyl-CoA
+
HCO3-
+
NADH

Synonyms

Aldh6a1, dddC, FG99_15390, KES23460, malonate-semialdehyde dehydrogenase, methylmalonate semialdehyde dehydrogenase, methylmalonate semialdehyde dehydrogenase protein, methylmalonate-semialdehyde dehydrogenase, methylmalonic acid semialdehyde dehydrogenase, MMSADH, MMSDH, MSDH, NAD-dependent malonate-semialdehyde dehydrogenase, OdoMMSDH, OsALDH6, PA3570, SSO1218

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.27 methylmalonate-semialdehyde dehydrogenase (CoA-acylating)

Substrates Products

Substrates Products on EC 1.2.1.27 - methylmalonate-semialdehyde dehydrogenase (CoA-acylating)

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-methyl-3-oxopropanoate + CoA + H2O + NAD+
propanoyl-CoA + HCO3- + NADH
show the reaction diagram
2-methyl-3-oxopropanoate + CoA + NAD+
propanoyl-CoA + CO2 + NADH
show the reaction diagram
2-methylbutyraldehyde + CoA + NAD+
?
show the reaction diagram
-
low activity
-
-
?
acetaldehyde + CoA + NAD+
?
show the reaction diagram
-
low activity
-
-
?
butyraldehyde + CoA + NAD+
?
show the reaction diagram
-
low activity
-
-
?
isobutyraldehyde + CoA + NAD+
?
show the reaction diagram
-
low activity
-
-
?
malonate semialdehyde + CoA + H2O + NAD+
acetyl-CoA + CO2 + NADH
show the reaction diagram
malonate semialdehyde + CoA + NAD+
acetyl-CoA + CO2 + NADH
show the reaction diagram
malondialdehyde + CoA + NAD+
?
show the reaction diagram
-
low activity
-
-
?
methylmalonate semialdehyde + CoA + H2O + NAD+
propanoyl-CoA + HCO3- + NADH
show the reaction diagram
methylmalonate-semialdehyde + CoA + NAD+
propionyl-CoA + NADH + H+ + HCO3-
show the reaction diagram
-
-
-
-
?
p-nitrophenyl acetate + CoA + NAD+
p-nitrophenol + acetyl-CoA + NADH
show the reaction diagram
-
-
-
ir
propanal + 2-mercaptoethanol + NAD+
? + NADH
show the reaction diagram
propanal + CoA + NAD+
propanoyl-CoA + NADH
show the reaction diagram
propanal + NAD+
? + NADH
show the reaction diagram
-
-
-
?
propionaldehyde + CoA + H2O + NAD+
?
show the reaction diagram
no physiological substrate
-
-
?
propionaldehyde + CoA + NAD+
? + NADH
show the reaction diagram
highest activity, no physiological substrate for MSDH, it only forms the same thiopropionyl enzyme intermediate as methylmalonate semialdehyde and malonate semialdehyde
-
-
?
propionaldehyde + CoA + NAD+
propanoyl-CoA + NADH
show the reaction diagram
-
-
-
-
?
succinate semialdehyde + CoA + NAD+
?
show the reaction diagram
-
very low activity
-
-
?
additional information
?
-