1.2.1.27: methylmalonate-semialdehyde dehydrogenase (CoA-acylating)

This is an abbreviated version!
For detailed information about methylmalonate-semialdehyde dehydrogenase (CoA-acylating), go to the full flat file.

Word Map on EC 1.2.1.27

Reaction

2-Methyl-3-oxopropanoate
+
CoA
+
H2O
+
NAD+
=
propanoyl-CoA
+
HCO3-
+
NADH

Synonyms

Aldh6a1, dddC, FG99_15390, KES23460, malonate-semialdehyde dehydrogenase, methylmalonate semialdehyde dehydrogenase, methylmalonate semialdehyde dehydrogenase protein, methylmalonate-semialdehyde dehydrogenase, methylmalonic acid semialdehyde dehydrogenase, MMSADH, MMSDH, MSDH, NAD-dependent malonate-semialdehyde dehydrogenase, OdoMMSDH, OsALDH6, PA3570, SSO1218

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.27 methylmalonate-semialdehyde dehydrogenase (CoA-acylating)

Turnover Number

Turnover Number on EC 1.2.1.27 - methylmalonate-semialdehyde dehydrogenase (CoA-acylating)

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.003 - 1.1
2-Methyl-3-oxopropanoate
2.8 - 12.6
CoA
0.02
malonate semialdehyde
0.003
methylmalonate semialdehyde
30°C, pH 8.2
0.02 - 2.2
NAD+
0.03
propionaldehyde
additional information
additional information
-
Kcat-value of CoA for R301L mutant enzyme under steady-state conditions with propionaldehyde is above 3 1/sec at pH 8.2 and 30°C
-