1.2.1.3: aldehyde dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about aldehyde dehydrogenase (NAD+), go to the full flat file.

Word Map on EC 1.2.1.3

Reaction

an aldehyde
+
NAD+
+
H2O
=
a carboxylate
+
NADH
+
H+

Synonyms

ADH, AdhE, AHD-M1, ALD1A1, ALD4, ALDDH, aldehyde dehydrogenase, aldehyde dehydrogenase (NAD), aldehyde dehydrogenase 1, aldehyde dehydrogenase 1A1, aldehyde dehydrogenase 1A3, aldehyde dehydrogenase 1B1, aldehyde dehydrogenase 2, aldehyde dehydrogenase 3A1, aldehyde dehydrogenase 7A1, aldehyde dehydrogenase class 1, aldehyde dehydrogenase type 2, Aldehyde dehydrogenase [NAD+], Aldehyde dehydrogenase, cytosolic, Aldehyde dehydrogenase, microsomal, aldehyde dehydrogenase-2, aldehyde dehydrogenase7, aldehyde:NAD+ oxidoreductase, ALDH, ALDH 2, ALDH I, ALDH II, ALDH-2, ALDH-E1, ALDH-E2, ALDH1, ALDH1-NL, ALDH1A1, Aldh1a2, Aldh1a3, Aldh1a7, Aldh1b1, ALDH2, ALDH2(1), ALDH2(2), ALDH2(3), ALDH22A1, ALDH2B8, ALDH2C4, ALDH3A1, ALDH3A2, Aldh3b1, ALDH3H1, ALDH5A, ALDH7, Aldh7a1, Aldh8a1, ALDHI, ALDHX, ALHDII, Allergen Alt a 10, aryl-aldehyde dehydrogenases, BADH, benzaldehyde dehydrogenase, Brassica turgor-responsive/drought-induced gene 26 protein, Bt-Aldh, Btg-26, class 1 aldehyde dehydrogenase, class 2 aldehyde dehydrogenase, class I ALDH, CoA-independent aldehyde dehydrogenase, coniferyl-aldehyde dehydrogenase, Cphy_1178, ETA-crystallin, FeaB-K-12, gamma-aminobutyraldehyde dehydrogenase, hALDH2, irreversible NAD+-dependent aldehyde dehydrogenase, K(+)-ACDH, K(+)-activated acetaldehyde dehydrogenase, KGSADH, m-methylbenzaldehyde dehydrogenase, Matured fruit 60 kDa protein, MF-60, Mg(2+)-ACDH, Mg(2+)-activated acetaldehyde dehydrogenase, mitochondrial aldehyde dehydrogenase, NAD+-dependent aldehyde dehydrogenase, NAD+-dependent ALDH, NAD+-linked aldehyde dehydrogenase, NAD+-pimelic semialdehyde-dependent aldehyde dehydrogenase, NAD+-specific ALDH, NAD-aldehyde dehydrogenase, NAD-dependent 4-hydroxynonenal dehydrogenase, NAD-dependent aldehyde dehydrogenase, NAD-linked aldehyde dehydrogenase, Non-lens ALDH1, p-ALDH2, P51, phenylacetaldehyde dehydrogenase, PhnN, phnY, phosphonoacetaldehyde dehydrogenase, phosphonoacetaldehyde oxidase, PM-ALDH9, PnAA dehydrogenase, propionaldehyde dehydrogenase, PuuC, R-aminobutyraldehyde dehydrogenase, RALDH, RALDH(II), RalDH1, Retinal dehydrogenase, retinal dehydrogenase type I, sALDH, salvery aldehyde dehydrogenase, ThnG, Turgor-responsive protein 26G, yALDH, YneI

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.3 aldehyde dehydrogenase (NAD+)

KCat KM Value

KCat KM Value on EC 1.2.1.3 - aldehyde dehydrogenase (NAD+)

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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
41.44
3-hydroxypropionaldehyde
-
recombinant enzyme, in 50 mM potassium phosphate buffer, at pH 8.0 and 45°C
0.18 - 150
acetaldehyde
1.6 - 4.7
alpha-aminoadipate semialdehyde
1.98 - 117.2
Butyraldehyde
0.11
DL-glyceraldehyde
-
in 50 mM Tris/HCl, at pH 8.0 and 80°C
0.14
DL-glyceraldehyde 3-phosphate
-
in 50 mM Tris/HCl, at pH 8.0 and 80°C
115 - 154
Hexanal
1.93
hexanaldehyde
A9KN57
at pH 8.0 and 21°C
121.9
Isovaleraldehyde
-
recombinant enzyme, in 50 mM potassium phosphate buffer, at pH 8.0 and 45°C
0.006 - 254.7
NAD+
2700
NADH
-
at pH 7.0 and 55°C
0.19 - 0.98
NADP+
213 - 2166
Nonanal
2.47
pentanaldehyde
A9KN57
at pH 8.0 and 21°C
0.517 - 3.13
propanal
4.21
propionaldehyde
A9KN57
at pH 8.0 and 21°C
5.3 - 12.4
trans-2-hexenal
120 - 918
trans-2-nonenal
207.1
Valeraldehyde
-
recombinant enzyme, in 50 mM potassium phosphate buffer, at pH 8.0 and 45°C