1.2.1.3: aldehyde dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about aldehyde dehydrogenase (NAD+), go to the full flat file.

Word Map on EC 1.2.1.3

Reaction

an aldehyde
+
NAD+
+
H2O
=
a carboxylate
+
NADH
+
H+

Synonyms

ADH, AdhE, AHD-M1, ALD1A1, ALD4, ALDDH, aldehyde dehydrogenase, aldehyde dehydrogenase (NAD), aldehyde dehydrogenase 1, aldehyde dehydrogenase 1A1, aldehyde dehydrogenase 1A3, aldehyde dehydrogenase 1B1, aldehyde dehydrogenase 2, aldehyde dehydrogenase 3A1, aldehyde dehydrogenase 7A1, aldehyde dehydrogenase class 1, aldehyde dehydrogenase type 2, Aldehyde dehydrogenase [NAD+], Aldehyde dehydrogenase, cytosolic, Aldehyde dehydrogenase, microsomal, aldehyde dehydrogenase-2, aldehyde dehydrogenase7, aldehyde:NAD+ oxidoreductase, ALDH, ALDH 2, ALDH I, ALDH II, ALDH-2, ALDH-E1, ALDH-E2, ALDH1, ALDH1-NL, ALDH1A1, Aldh1a2, Aldh1a3, Aldh1a7, Aldh1b1, ALDH2, ALDH2(1), ALDH2(2), ALDH2(3), ALDH22A1, ALDH2B8, ALDH2C4, ALDH3A1, ALDH3A2, Aldh3b1, ALDH3H1, ALDH5A, ALDH7, Aldh7a1, Aldh8a1, ALDHI, ALDHX, ALHDII, Allergen Alt a 10, aryl-aldehyde dehydrogenases, BADH, benzaldehyde dehydrogenase, Brassica turgor-responsive/drought-induced gene 26 protein, Bt-Aldh, Btg-26, class 1 aldehyde dehydrogenase, class 2 aldehyde dehydrogenase, class I ALDH, CoA-independent aldehyde dehydrogenase, coniferyl-aldehyde dehydrogenase, Cphy_1178, ETA-crystallin, FeaB-K-12, gamma-aminobutyraldehyde dehydrogenase, hALDH2, irreversible NAD+-dependent aldehyde dehydrogenase, K(+)-ACDH, K(+)-activated acetaldehyde dehydrogenase, KGSADH, m-methylbenzaldehyde dehydrogenase, Matured fruit 60 kDa protein, MF-60, Mg(2+)-ACDH, Mg(2+)-activated acetaldehyde dehydrogenase, mitochondrial aldehyde dehydrogenase, NAD+-dependent aldehyde dehydrogenase, NAD+-dependent ALDH, NAD+-linked aldehyde dehydrogenase, NAD+-pimelic semialdehyde-dependent aldehyde dehydrogenase, NAD+-specific ALDH, NAD-aldehyde dehydrogenase, NAD-dependent 4-hydroxynonenal dehydrogenase, NAD-dependent aldehyde dehydrogenase, NAD-linked aldehyde dehydrogenase, Non-lens ALDH1, p-ALDH2, P51, phenylacetaldehyde dehydrogenase, PhnN, phnY, phosphonoacetaldehyde dehydrogenase, phosphonoacetaldehyde oxidase, PM-ALDH9, PnAA dehydrogenase, propionaldehyde dehydrogenase, PuuC, R-aminobutyraldehyde dehydrogenase, RALDH, RALDH(II), RalDH1, Retinal dehydrogenase, retinal dehydrogenase type I, sALDH, salvery aldehyde dehydrogenase, ThnG, Turgor-responsive protein 26G, yALDH, YneI

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.3 aldehyde dehydrogenase (NAD+)

Turnover Number

Turnover Number on EC 1.2.1.3 - aldehyde dehydrogenase (NAD+)

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.039
(R)-trans-4-hydroxy-2-nonenal
ALDH2, in 40 mM sodium phosphate buffer (pH 7.4), at 37C
0.04
(S)-trans-4-hydroxy-2-nonenal
ALDH2, in 40 mM sodium phosphate buffer (pH 7.4), at 37C
0.667
2,4-dinitrobenzaldehyde
-
enzyme ALDH-2
4
2-naphthaldehyde
-
enzyme ALDH-2
1.57
2-quinolinone-4-carboxaldehyde
-
enzyme ALDH-2
1.42
3,4-dimethoxybenzaldehyde
-
enzyme ALDH-2
4.91 - 28.54
3-hydroxypropionaldehyde
0.26
3-hydroxypropionic acid
-
with NADH as cofactor, in 50 mM potassium phosphate buffer (pH 8.0), at 37C
1.5
3-oxopropyl phosphonate
-
wild type enzyme, at pH 7.5 and 30C
27.7
3-Pyridinecarboxaldehyde
-
enzyme ALDH-2
4.42
4-methoxy-1-naphthaldehyde
-
enzyme ALDH-1
2.67
5-(dimethylamino)-2-naphthaldehyde
-
enzyme ALDH-1
0.158 - 0.25
5-bromo-1-naphthaldehyde
0.55 - 0.833
5-nitro-1-naphthaldehyde
0.983
6,7-dimethoxycoumarin-3-carboxaldehyde
-
enzyme ALDH-2
0.617
6-(dimethylamino)-2-naphthaldehyde
-
enzyme ALDH-2
0.983
6-methoxy-2-quinolinone-4-carboxaldehyde
-
enzyme ALDH-2
2.17
7-(dimethylamino)-2-quinolinone-4-carboxaldehyde
-
enzyme ALDH-2
1.3
7-(dimethylamino)-coumarin-3-carboxaldehyde
-
enzyme ALDH-2
7.9
7-(dimethylamino)coumarin-4-carboxaldehyde
-
enzyme ALDH-2
1.08
7-acetoxycoumarin-3-carboxaldehyde
-
enzyme ALDH-2
8.33
7-hydroxycoumarin-3-carboxaldehyde
-
enzyme ALDH-2
5.33
7-methoxy-2-quinolinone-4-carboxaldehyde
-
enzyme ALDH-2
3.17
7-methoxycoumarin-3-carboxaldehyde
-
enzyme ALDH-2
0.26 - 240
acetaldehyde
0.3 - 1
alpha-aminoadipate semialdehyde
15.2
alpha-phenylpropanal
-
enzyme ALDH-2
0.0425 - 17.37
benzaldehyde
3.44 - 26.95
Butyraldehyde
3.83 - 11.7
decanal
0.92
DL-glyceraldehyde
-
in 50 mM Tris/HCl, at pH 8.0 and 80C
0.83
DL-glyceraldehyde 3-phosphate
-
in 50 mM Tris/HCl, at pH 8.0 and 80C
2.83 - 6
fluorene-2-carboxaldehyde
67.5
formaldehyde
-
enzyme ALDH-2
0.04
glutathione-4-oxonon-2-enal
-
50 mM sodium phosphate buffer pH 7.4, 1 mM NAD+, 37C
1.29
glyceraldehyde
-
-
0.098 - 0.28
glyceraldehyde 3-phosphate
1.2
glycolaldehyde
-
-
4.33 - 22.7
Heptanal
4.17 - 28.5
Hexanal
5.61
hexanaldehyde
A9KN57
at pH 8.0 and 21C
12.3
hydrocinnamaldehyde
-
enzyme ALDH-2
9.33 - 11.3
Indole-3-acetaldehyde
27.31
Isovaleraldehyde
-
with NAD+ as cofactor, in 50 mM potassium phosphate buffer (pH 8.0), at 37C
1
m-hydroxybenzaldehyde
-
enzyme ALDH-2
5.83
m-methoxybenzaldehyde
-
enzyme ALDH-2
4.5
m-methylbenzaldehyde
-
enzyme ALDH-2
1.19
malondialdehyde
-
-
0.0667 - 33.9
NAD+
240
NADH
-
at pH 7.0 and 55C
1.63 - 3.71
NADP+
13 - 17.9
Nonanal
0.367
o-methoxybenzaldehyde
-
enzyme ALDH-2
2.75
o-methylbenzaldehyde
-
enzyme ALDH-2
1.23
o-nitrobenzaldehyde
-
enzyme ALDH-2
4.17 - 15
octanal
2.33
p-(dimethylamino)-benzaldehyde
-
enzyme ALDH-2
2.13
p-(dimethylamino)benzaldehyde
-
enzyme ALDH-1
1.5 - 8.17
p-(dimethylamino)cinnamaldehyde
2.5
p-Methoxybenzaldehyde
-
enzyme ALDH-2
3
p-methylbenzaldehyde
-
enzyme ALDH-2
0.23 - 7.17
p-nitrobenzaldehyde
0.45
p-nitrocinnamaldehyde
-
enzyme ALDH-2
0.26
p-nitrophenyl acetate
-
-
8.17 - 22.8
pentanal
5.44
pentanaldehyde
A9KN57
at pH 8.0 and 21C
0.3
phenanthrene-9-carboxaldehyde
-
enzyme ALDH-2
1.39 - 50
phenylacetaldehyde
0.01 - 2.2
phosphonoacetaldehyde
0.42 - 19.7
propanal
3.45 - 24.35
propionaldehyde
11.2
quinoline-3-carboxaldehyde
-
enzyme ALDH-2
4.67
quinoline-4-carboxaldehyde
-
enzyme ALDH-2
0.76
Succinic semialdehyde
-
-
1.1 - 2.2
trans-2-hexenal
2.7 - 3.8
trans-2-nonenal
2.5 - 7.83
trans-cinnamaldehyde
26.24
Valeraldehyde
-
with NAD+ as cofactor, in 50 mM potassium phosphate buffer (pH 8.0), at 37C
additional information
additional information
-