1.2.1.30: carboxylate reductase (NADP+)
This is an abbreviated version!
For detailed information about carboxylate reductase (NADP+), go to the full flat file.
Word Map on EC 1.2.1.30
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1.2.1.30
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synthesis
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bio-based
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fragrance
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autoinduction
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phosphopantetheinylation
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over-reduction
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benzaldehyde
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industry
- 1.2.1.30
- synthesis
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bio-based
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fragrance
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autoinduction
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phosphopantetheinylation
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over-reduction
- benzaldehyde
- industry
Reaction
Synonyms
aromatic acid reductase, aryl aldehyde:NADP+ oxidoreductase, aryl-aldehyde dehydrogenase (NADP+), aryl-aldehyde oxidoreductase, ATP/NADPH-dependent carboxylic acid reductase, CAR, carboxylate reductase, carboxylate reductases, Carboxylic acid reductase, kaCAR, mab3CAR, maCAR, mmCAR, mpCAR, msCAR, naCAR, NcCAR, niCAR, noCAR, tpCAR, type I CAR, type III CAR
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Application on EC 1.2.1.30 - carboxylate reductase (NADP+)
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APPLICATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
industry
vanillic acid reduction in Escherichia coli BL21-CodonPlus(DE3)-RP/pPV2.85 cells containing car, npt and gdh is complete in 6 h, and is faster than in cells containing only car and/or npt. The availability of Escherichia coli BL21-CodonPlus(DE3)-RP/pPV2.85 expressing holo-Car and Gdh provides a means of generating a range of value-added aldehydes or alcohols of importance in pharmaceutical, food and agricultural industries. Uses of directed evolution and related mutant generating processes, may enable a Car-system with broader substrate specificities and one that is capable of achieving much higher product yields
synthesis
synthesis
by combining the carboxylic acid reductase-dependent pathway with an exogenous fatty acid-generating lipase, natural oils (coconut oil, palm oil, and algal oil bodies) can be enzymatically converted into fatty alcohols across a broad chain length range (C8-C18)
synthesis
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carboxylic acid reductases (CARs) catalyze the conversion of carboxylic acids to aldehydes, which are a valuable class of chemicals for many consumer and industrial applications. CARs generally exhibit broad substrate specificity that encompasses aromatic, aliphatic, and di/tri-carboxylic acids, enabling the development of biosynthetic pathways to a wide array of potential aldehyde products. De novo biosynthesis utilizing CARs have produced industrially relevant products including aromatic aldehydes, fatty and aromatic alcohols, and alkanes. De novo synthetic pathways implementing CARs have enabled the production of sustainable aldehyde products or utilized highly reactive aldehydes as intermediates in the production of chemicals including amines, alcohols, and alkanes. Aromatic aldehydes, such as vanillin, benzaldehyde, and cinnamaldehyde are particularly valuable in the fragrance and flavoring industries and are produced from petroleum feedstocks in large quantities. Aldehydes as reactive intermediates in biosynthetic pathways, overview
synthesis
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carboxylic acid reductases (CARs) catalyze the conversion of carboxylic acids to aldehydes, which are a valuable class of chemicals for many consumer and industrial applications. CARs generally exhibit broad substrate specificity that encompasses aromatic, aliphatic, and di/tri-carboxylic acids, enabling the development of biosynthetic pathways to a wide array of potential aldehyde products. De novo biosynthesis utilizing CARs have produced industrially relevant products including aromatic aldehydes, fatty and aromatic alcohols, and alkanes. De novo synthetic pathways implementing CARs have enabled the production of sustainable aldehyde products or utilized highly reactive aldehydes as intermediates in the production of chemicals including amines, alcohols, and alkanes. Aromatic aldehydes, such as vanillin, benzaldehyde, and cinnamaldehyde are particularly valuable in the fragrance and flavoring industries and are produced from petroleum feedstocks in large quantities. Aldehydes as reactive intermediates in biosynthetic pathways, overview
synthesis
-
carboxylic acid reductases (CARs) catalyze the conversion of carboxylic acids to aldehydes, which are a valuable class of chemicals for many consumer and industrial applications. CARs generally exhibit broad substrate specificity that encompasses aromatic, aliphatic, and di/tri-carboxylic acids, enabling the development of biosynthetic pathways to a wide array of potential aldehyde products. De novo biosynthesis utilizing CARs have produced industrially relevant products including aromatic aldehydes, fatty and aromatic alcohols, and alkanes. De novo synthetic pathways implementing CARs have enabled the production of sustainable aldehyde products or utilized highly reactive aldehydes as intermediates in the production of chemicals including amines, alcohols, and alkanes. Aromatic aldehydes, such as vanillin, benzaldehyde, and cinnamaldehyde are particularly valuable in the fragrance and flavoring industries and are produced from petroleum feedstocks in large quantities. Aldehydes as reactive intermediates in biosynthetic pathways, overview
synthesis
-
carboxylic acid reductases (CARs) catalyze the conversion of carboxylic acids to aldehydes, which are a valuable class of chemicals for many consumer and industrial applications. CARs generally exhibit broad substrate specificity that encompasses aromatic, aliphatic, and di/tri-carboxylic acids, enabling the development of biosynthetic pathways to a wide array of potential aldehyde products. De novo biosynthesis utilizing CARs have produced industrially relevant products including aromatic aldehydes, fatty and aromatic alcohols, and alkanes. De novo synthetic pathways implementing CARs have enabled the production of sustainable aldehyde products or utilized highly reactive aldehydes as intermediates in the production of chemicals including amines, alcohols, and alkanes. Aromatic aldehydes, such as vanillin, benzaldehyde, and cinnamaldehyde are particularly valuable in the fragrance and flavoring industries and are produced from petroleum feedstocks in large quantities. Aldehydes as reactive intermediates in biosynthetic pathways, overview
synthesis
-
carboxylic acid reductases (CARs) catalyze the conversion of carboxylic acids to aldehydes, which are a valuable class of chemicals for many consumer and industrial applications. CARs generally exhibit broad substrate specificity that encompasses aromatic, aliphatic, and di/tri-carboxylic acids, enabling the development of biosynthetic pathways to a wide array of potential aldehyde products. De novo biosynthesis utilizing CARs have produced industrially relevant products including aromatic aldehydes, fatty and aromatic alcohols, and alkanes. De novo synthetic pathways implementing CARs have enabled the production of sustainable aldehyde products or utilized highly reactive aldehydes as intermediates in the production of chemicals including amines, alcohols, and alkanes. Aromatic aldehydes, such as vanillin, benzaldehyde, and cinnamaldehyde are particularly valuable in the fragrance and flavoring industries and are produced from petroleum feedstocks in large quantities. Aldehydes as reactive intermediates in biosynthetic pathways, overview
synthesis
carboxylic acid reductases (CARs) catalyze the conversion of carboxylic acids to aldehydes, which are a valuable class of chemicals for many consumer and industrial applications. CARs generally exhibit broad substrate specificity that encompasses aromatic, aliphatic, and di/tri-carboxylic acids, enabling the development of biosynthetic pathways to a wide array of potential aldehyde products. De novo biosynthesis utilizing CARs have produced industrially relevant products including aromatic aldehydes, fatty and aromatic alcohols, and alkanes. De novo synthetic pathways implementing CARs have enabled the production of sustainable aldehyde products or utilized highly reactive aldehydes as intermediates in the production of chemicals including amines, alcohols, and alkanes. Aromatic aldehydes, such as vanillin, benzaldehyde, and cinnamaldehyde are particularly valuable in the fragrance and flavoring industries and are produced from petroleum feedstocks in large quantities. Recombinant enzyme expression in Saccharomyces cerevisiae and Saccharomyces pombe and an engineered aldehyde-accumulating Escherichia coli strain for de novo production of vanillin from glucose. Aldehydes as reactive intermediates in biosynthetic pathways, overview
synthesis
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carboxylic acid reductases (CARs) catalyze the conversion of carboxylic acids to aldehydes, which are a valuable class of chemicals for many consumer and industrial applications. CARs generally exhibit broad substrate specificity that encompasses aromatic, aliphatic, and di/tri-carboxylic acids, enabling the development of biosynthetic pathways to a wide array of potential aldehyde products. De novo biosynthesis utilizing CARs have produced industrially relevant products including aromatic aldehydes, fatty and aromatic alcohols, and alkanes. De novo synthetic pathways implementing CARs have enabled the production of sustainable aldehyde products or utilized highly reactive aldehydes as intermediates in the production of chemicals including amines, alcohols, and alkanes. Aromatic aldehydes, such as vanillin, benzaldehyde, and cinnamaldehyde are particularly valuable in the fragrance and flavoring industries and are produced from petroleum feedstocks in large quantities. The CAR from Mycobacterium marinum (mmCAR) reduces a number of aliphatic acids ranging from C3 to C18, expanding the potential of CARs in synthetic pathways. Aldehydes as reactive intermediates in biosynthetic pathways, overview
synthesis
carboxylic acid reductases (CARs) catalyze the conversion of carboxylic acids to aldehydes, which are a valuable class of chemicals for many consumer and industrial applications. CARs generally exhibit broad substrate specificity that encompasses aromatic, aliphatic, and di/tri-carboxylic acids, enabling the development of biosynthetic pathways to a wide array of potential aldehyde products. De novo biosynthesis utilizing CARs have produced industrially relevant products including aromatic aldehydes, fatty and aromatic alcohols, and alkanes. De novo synthetic pathways implementing CARs have enabled the production of sustainable aldehyde products or utilized highly reactive aldehydes as intermediates in the production of chemicals including amines, alcohols, and alkanes. Aromatic aldehydes, such as vanillin, benzaldehyde, and cinnamaldehyde are particularly valuable in the fragrance and flavoring industries and are produced from petroleum feedstocks in large quantities. The CAR from Mycobacterium marinum (mmCAR) reduces a number of aliphatic acids ranging from C3 to C18, expanding the potential of CARs in synthetic pathways. Aldehydes as reactive intermediates in biosynthetic pathways, overview
synthesis
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carboxylic acid reductases are important enzymes in the toolbox for sustainable chemistry and provide specific use as biocatalysts
synthesis
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carboxylic acid reductases are important enzymes in the toolbox for sustainable chemistry and provide specific use as biocatalysts
synthesis
-
carboxylic acid reductases are important enzymes in the toolbox for sustainable chemistry and provide specific use as biocatalysts
synthesis
-
carboxylic acid reductases are important enzymes in the toolbox for sustainable chemistry and provide specific use as biocatalysts, application for the reduction of fatty acids to fatty alcohols
synthesis
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carboxylic acid reductases are important enzymes in the toolbox for sustainable chemistry and provide specific use as biocatalysts, application for the reduction of fatty acids to fatty alcohols
synthesis
-
carboxylic acid reductases are important enzymes in the toolbox for sustainable chemistry and provide specific use as biocatalysts, application for the reduction of fatty acids to fatty alcohols
synthesis
-
carboxylic acid reductases are important enzymes in the toolbox for sustainable chemistry and provide specific use as biocatalysts, application for the reduction of fatty acids to fatty alcohols
synthesis
-
carboxylic acid reductases are important enzymes in the toolbox for sustainable chemistry and provide specific use as biocatalysts, application for the reduction of fatty acids to fatty alcohols
synthesis
-
carboxylic acid reductases are important enzymes in the toolbox for sustainable chemistry and provide specific use as biocatalysts, application for the reduction of fatty acids to fatty alcohols
synthesis
carboxylic acid reductases are important enzymes in the toolbox for sustainable chemistry and provide specific use as biocatalysts, application for the reduction of fatty acids to fatty alcohols
synthesis
carboxylic acid reductases are important enzymes in the toolbox for sustainable chemistry and provide specific use as biocatalysts. The reduction of racemic ibuprofen by whole Nocardia iowensis cells gives an enantiomeric excess (ee) of 61.2%, which is attributed to enantioselectivity by niCAR based on kinetic data for its reduction of (S)-(+)- and (R)-(-)-ibuprofen enantiomers
synthesis
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the enzyme can be useful for aromatic aldehyde synthesis on industrial level. The product selectivity is an essential asset of the enzyme if it is used for the biocatalytic synthesis of organic molecules on the preparative level
synthesis
the enzyme can be useful for aromatic aldehyde synthesis on industrial level. The product selectivity is an essential asset of the enzyme if it is used for the biocatalytic synthesis of organic molecules on the preparative level
synthesis
the enzyme can be useful for aromatic aldehyde synthesis on industrial level. The product selectivity is an essential asset of the enzyme if it is used for the biocatalytic synthesis of organic molecules on the preparative level
synthesis
the enzyme can be useful for aromatic aldehyde synthesis on industrial level. The product selectivity is an essential asset of the enzyme if it is used for the biocatalytic synthesis of organic molecules on the preparative level
synthesis
the enzyme can be useful for aromatic aldehyde synthesis on industrial level. The product selectivity is an essential asset of the enzyme if it is used for the biocatalytic synthesis of organic molecules on the preparative level
synthesis
-
the enzyme can be useful for aromatic aldehyde synthesis on industrial level. The product selectivity is an essential asset of the enzyme if it is used for the biocatalytic synthesis of organic molecules on the preparative level
-
synthesis
-
carboxylic acid reductases are important enzymes in the toolbox for sustainable chemistry and provide specific use as biocatalysts, application for the reduction of fatty acids to fatty alcohols
-
synthesis
-
the enzyme can be useful for aromatic aldehyde synthesis on industrial level. The product selectivity is an essential asset of the enzyme if it is used for the biocatalytic synthesis of organic molecules on the preparative level
-
synthesis
-
carboxylic acid reductases (CARs) catalyze the conversion of carboxylic acids to aldehydes, which are a valuable class of chemicals for many consumer and industrial applications. CARs generally exhibit broad substrate specificity that encompasses aromatic, aliphatic, and di/tri-carboxylic acids, enabling the development of biosynthetic pathways to a wide array of potential aldehyde products. De novo biosynthesis utilizing CARs have produced industrially relevant products including aromatic aldehydes, fatty and aromatic alcohols, and alkanes. De novo synthetic pathways implementing CARs have enabled the production of sustainable aldehyde products or utilized highly reactive aldehydes as intermediates in the production of chemicals including amines, alcohols, and alkanes. Aromatic aldehydes, such as vanillin, benzaldehyde, and cinnamaldehyde are particularly valuable in the fragrance and flavoring industries and are produced from petroleum feedstocks in large quantities. The CAR from Mycobacterium marinum (mmCAR) reduces a number of aliphatic acids ranging from C3 to C18, expanding the potential of CARs in synthetic pathways. Aldehydes as reactive intermediates in biosynthetic pathways, overview
-
synthesis
-
the enzyme can be useful for aromatic aldehyde synthesis on industrial level. The product selectivity is an essential asset of the enzyme if it is used for the biocatalytic synthesis of organic molecules on the preparative level
-
synthesis
-
the enzyme can be useful for aromatic aldehyde synthesis on industrial level. The product selectivity is an essential asset of the enzyme if it is used for the biocatalytic synthesis of organic molecules on the preparative level
-
synthesis
-
the enzyme can be useful for aromatic aldehyde synthesis on industrial level. The product selectivity is an essential asset of the enzyme if it is used for the biocatalytic synthesis of organic molecules on the preparative level
-
synthesis
-
carboxylic acid reductases are important enzymes in the toolbox for sustainable chemistry and provide specific use as biocatalysts
-
synthesis
-
the enzyme can be useful for aromatic aldehyde synthesis on industrial level. The product selectivity is an essential asset of the enzyme if it is used for the biocatalytic synthesis of organic molecules on the preparative level
-
synthesis
-
the enzyme can be useful for aromatic aldehyde synthesis on industrial level. The product selectivity is an essential asset of the enzyme if it is used for the biocatalytic synthesis of organic molecules on the preparative level
-
synthesis
-
the enzyme can be useful for aromatic aldehyde synthesis on industrial level. The product selectivity is an essential asset of the enzyme if it is used for the biocatalytic synthesis of organic molecules on the preparative level
-
