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1.2.1.30: carboxylate reductase (NADP+)

This is an abbreviated version!
For detailed information about carboxylate reductase (NADP+), go to the full flat file.

Word Map on EC 1.2.1.30

Reaction

an aromatic aldehyde
+
NADP+
+
AMP
+
diphosphate
=
an aromatic acid
+
NADPH
+
H+
+
ATP

Synonyms

aromatic acid reductase, aryl aldehyde:NADP+ oxidoreductase, aryl-aldehyde dehydrogenase (NADP+), aryl-aldehyde oxidoreductase, ATP/NADPH-dependent carboxylic acid reductase, CAR, carboxylate reductase, carboxylate reductases, Carboxylic acid reductase, kaCAR, mab3CAR, maCAR, mmCAR, mpCAR, msCAR, naCAR, NcCAR, niCAR, noCAR, tpCAR, type I CAR, type III CAR

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.30 carboxylate reductase (NADP+)

Substrates Products

Substrates Products on EC 1.2.1.30 - carboxylate reductase (NADP+)

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(E)-3-phenylprop-2-enoate + NADPH + H+ + ATP
(E)-3-phenylprop-2-enal + NADP+ + AMP + diphosphate
show the reaction diagram
(E)-3-phenylprop-2-enoate + NADPH + H+ + ATP
(E)-3-phenylprop2-enal + NADP+ + AMP + diphosphate
show the reaction diagram
(R)-ibuprofen + NADPH + ATP
(2R)-2-(4-(2-methylpropyl)phenyl)propanal + NADP+ + AMP + H2O
show the reaction diagram
2-methoxybenzoate + NADPH + H+ + ATP
2-methoxybenzaldehyde + NADP+ + AMP + diphosphate
show the reaction diagram
-
-
-
-
?
3-hydroxypropionate + NADPH + H+ + ATP
3-hydroxypropanal + NADP+ + AMP + diphosphate
show the reaction diagram
3-hydroxypropionate + NADPH + H+ + ATP
? + NADP+ + AMP + diphosphate
show the reaction diagram
-
-
-
-
ir
3-methoxybenzoate + NADPH + H+ + ATP
3-methoxybenzaldehyde + NADP+ + AMP + diphosphate
show the reaction diagram
3-nitrobenzoate + NADPH + H+ + ATP
3-nitrobenzaldehyde + NADP+ + AMP + diphosphate
show the reaction diagram
3-oxo-3-phenylpropanoate + NADPH + H+ + ATP
3-oxo-3-phenylpropanal + NADP+ + AMP + diphosphate
show the reaction diagram
3-phenylprop-2-ynoate + NADPH + H+ + ATP
3-phenylprop-2-ynal + NADP+ + AMP + diphosphate
show the reaction diagram
3-phenylpropionate + NADPH + H+ + ATP
3-phenylpropionaldehyde + NADP+ + AMP + diphosphate
show the reaction diagram
4-hydroxybutyrate + NADPH + H+ + ATP
4-hydroxybutanal + NADP+ + AMP + diphosphate
show the reaction diagram
4-hydroxybutyrate + NADPH + H+ + ATP
? + NADP+ + AMP + diphosphate
show the reaction diagram
-
-
-
-
ir
4-methoxybenzoate + NADPH + H+ + ATP
4-methoxybenzaldehyde + NADP+ + AMP + diphosphate
show the reaction diagram
4-methylbenzoate + NADPH + H+ + ATP
4-methylbenzaldehyde + NADP+ + AMP + diphosphate
show the reaction diagram
4-nitrobenzoate + NADPH + H+ + ATP
4-nitrobenzaldehyde + NADP+ + AMP + diphosphate
show the reaction diagram
-
-
-
-
?
5-hydroxypentanoate + NADPH + H+ + ATP
5-hydroxypentanal + NADP+ + AMP + diphosphate
show the reaction diagram
5-hydroxypentanoate + NADPH + H+ + ATP
? + NADP+ + AMP + diphosphate
show the reaction diagram
-
-
-
-
ir
alpha-ketoglutaric acid + NADPH + ATP
? + NADP+ + AMP + phosphate
show the reaction diagram
-
-
-
?
aromatic acid + NADPH + H+ + ATP
aromatic aldehyde + NADP+ + AMP + diphosphate
show the reaction diagram
aromatic acids + NADPH + H+ + ATP
aromatic aldehydes + NADP+ + AMP + diphosphate + H2O
show the reaction diagram
aromatic carboxylate + NADPH + H+ + ATP
aromatic aldehyde + NADP+ + AMP + diphosphate
show the reaction diagram
benzaldehyde + NADP+ + benzoyladenosine 5'-monophosphate + phosphate
benzoate + NADPH + ATP
show the reaction diagram
-
-
-
-
r
benzoate + NADPH + ATP
benzaldehyde + NADP+ + AMP + phosphate
show the reaction diagram
benzoate + NADPH + H+ + ATP
benzaldehyde + NADP+ + AMP + diphosphate
show the reaction diagram
benzoic acid + ATP + NADPH + H+
benzaldehyde + AMP + diphosphate + NADP+
show the reaction diagram
highest turnover number
-
-
?
benzoic acid + NADPH + H+ + ATP
benzaldehyde + benzyl alcohol + NADP+ + AMP + diphosphate
show the reaction diagram
-
-
-
?
benzoic acid + NADPH + H+ + ATP
benzaldehyde + NADP+ + AMP + diphosphate
show the reaction diagram
butanoate + NADPH + H+ + ATP
butyraldehyde + NADP+ + AMP + diphosphate
show the reaction diagram
butyric acid + ATP + NADPH + H+
butyraldehyde + AMP + diphosphate + NADP+
show the reaction diagram
-
highest Km value
-
?
caffeic acid + NADPH + ATP
3-(3,4-dihydroxyphenyl)-2-propen-1-al + NADP+ + AMP + H2O
show the reaction diagram
-
-
-
?
capric acid + ATP + NADPH + H+
capraldehyde + AMP + diphosphate + NADP+
show the reaction diagram
-
-
-
?
caproic acid + ATP + NADPH + H+
caproaldehyde + AMP + diphosphate + NADP+
show the reaction diagram
-
-
-
?
caprylic acid + ATP + NADPH + H+
caprylaldehyde + AMP + diphosphate + NADP+
show the reaction diagram
-
-
-
?
cinnamate + NADPH + H+ + ATP
cinnamaldehyde + NADP+ + AMP + diphosphate
show the reaction diagram
cinnamic acid + NADPH + ATP
3-phenyl-2-propen-1-al + NADP+ + AMP + H2O
show the reaction diagram
cis-aconitic acid + NADPH + ATP
? + NADP+ + AMP + phosphate
show the reaction diagram
-
-
-
?
citric acid + NADPH + ATP
? + NADP+ + AMP + phosphate
show the reaction diagram
-
-
-
?
coniferic acid + NADPH + ATP
coniferyl aldehyde + NADP+ + AMP + phosphate
show the reaction diagram
-
-
-
?
D-malic acid + NADPH + ATP
? + NADP+ + AMP + phosphate
show the reaction diagram
-
-
-
?
DL-malic acid + NADPH + ATP
? + NADP+ + AMP + phosphate
show the reaction diagram
-
-
-
?
dodecanoate + NADPH + H+ + ATP
dodecanal + NADP+ + AMP + diphosphate
show the reaction diagram
fatty acid + ATP + NADPH + H+
fatty aldehyde + AMP + diphosphate + NADP+
show the reaction diagram
-
-
-
?
ferulic acid + NADPH + H+ + ATP
3-(4-hydroxy-3-methoxyphenyl)-2-propen-1-al + NADP+ + AMP + diphosphate
show the reaction diagram
-
-
-
?
ferulic acid + NADPH + H+ + ATP
ferulic acid + coniferyl aldehyde + coniferyl alcohol + NADP+ + AMP + diphosphate
show the reaction diagram
not completely reduced
-
-
?
furan-2-carboxylate + NADPH + H+ + ATP
furan-2-carbaldehyde + NADP+ + AMP + diphosphate
show the reaction diagram
glutarate + NADPH + H+ + ATP
5-oxopentanoate + 1,5-pentanedial + NADP+ + AMP + diphosphate
show the reaction diagram
glutarate + NADPH + H+ + ATP
? + NADP+ + AMP + diphosphate
show the reaction diagram
-
-
-
-
ir
hexanoate + NADPH + H+ + ATP
hexanal + NADP+ + AMP + diphosphate
show the reaction diagram
ibuprofen + NADPH + ATP
2-(4-isobutylphenyl)propanal + NADP+ + AMP + H2O
show the reaction diagram
L-malic acid + NADPH + ATP
? + NADP+ + AMP + phosphate
show the reaction diagram
-
-
-
?
lauric acid + ATP + NADPH + H+
lauraldehyde + AMP + diphosphate + NADP+
show the reaction diagram
highest catalytic efficiency
-
-
?
m-coumaric acid + NADPH + ATP
3-(3-hydroxyphenyl)-2-propen-1-al + NADP+ + AMP + H2O
show the reaction diagram
m-hydroxybenzoic acid + NADPH + ATP
m-hydroxybenzaldehyde + NADP+ + AMP + H2O
show the reaction diagram
malonate + NADPH + H+ + ATP
3-oxopropanoate + 1,3-propanedial + NADP+ + AMP + diphosphate
show the reaction diagram
malonate + NADPH + H+ + ATP
? + NADP+ + AMP + diphosphate
show the reaction diagram
-
-
-
-
ir
o-coumaric acid + NADPH + ATP
3-(2-hydroxyphenyl)-2-propen-1-al + NADP+ + AMP + H2O
show the reaction diagram
octadecanoate + NADPH + H+ + ATP
octadecanal + NADP+ + AMP + diphosphate
show the reaction diagram
octanoate + NADPH + H+ + ATP
octanal + NADP+ + AMP + diphosphate
show the reaction diagram
p-anisic acid + NADPH + ATP
p-methoxybenzaldehyde + NADP+ + AMP + H2O
show the reaction diagram
p-coumaric acid + NADPH + ATP
3-(4-hydroxphenyl)-2-propen-1-al + NADP+ + AMP + H2O
show the reaction diagram
p-hydroxybenzoic acid + NADPH + ATP
p-hydroxybenzaldehyde + NADP+ + AMP + H2O
show the reaction diagram
piperonylate + NADPH + H+ + ATP
piperonylaldehyde + NADP+ + AMP + diphosphate
show the reaction diagram
pyridine-2-carboxylate + NADPH + H+ + ATP
pyridine-2-carbaldehyde + NADP+ + AMP + diphosphate
show the reaction diagram
salicylic acid + NADPH + ATP
salicyl aldehyde + NADP+ + AMP + H2O
show the reaction diagram
sinapic acid + NADPH + ATP
3-(4-hydroxy-3,5-dimethoxyphenyl)-2-propen-1-al + NADP+ + AMP + H2O
show the reaction diagram
-
-
-
?
succinate + NADPH + H+ + ATP
4-oxobutanoate + 1,4-butanedial + NADP+ + AMP + diphosphate
show the reaction diagram
succinate + NADPH + H+ + ATP
? + NADP+ + AMP + diphosphate
show the reaction diagram
-
-
-
-
ir
thiophene-2-carboxylate + NADPH + H+ + ATP
thiophene-2-carbaldehyde + NADP+ + AMP + diphosphate
show the reaction diagram
trans-2-phenylcyclopropane-1-carboxylate + NADPH + H+ + ATP
trans-2-phenylcyclopropane-1-carbaldehyde + NADP+ + AMP + diphosphate
show the reaction diagram
trans-aconitic acid + NADPH + ATP
? + NADP+ + AMP + phosphate
show the reaction diagram
-
-
-
?
vanillate + NADPH + H+ + ATP
vanillin + NADP+ + AMP + diphosphate
show the reaction diagram
vanillic acid + NADPH + H+ + ATP
4-hydroxy-3-methoxybenzaldehyde + NADP+ + AMP + diphosphate
show the reaction diagram
vanillic acid + NADPH + H+ + ATP
vanillin + NADP+ + AMP + diphosphate
show the reaction diagram
vanillic acid + NADPH + H+ + ATP
vanillin + vanillyl alcohol + NADP+ + AMP + diphosphate
show the reaction diagram
-
with Escherichia coli BL21-CodonPlus(DE3)-RP/pPV2.83, in which recombinant Npt is expressed along with recombinant car, vanillic acid is reduced to vanillin and vanillyl alcohol, with vanillin (80%) as the major product. Escherichia coli BL21-CodonPlus(DE3)-RP/pHAT305 (expressing only recombinant Car) reduce only 50% of the vanillic acid starting material, with vanillyl alcohol being the major metabolite. With Escherichia coli BL21-CodonPlus(DE3)-RP/pPV2.83, in which recombinant car is presumed to be in the fully active, phosphopantetheinylated holo form, the rate of reduction of vanillic acid is much faster than that of vanillin to vanillyl alcohol by endogenous Escherichia coli aldehyde dehydrogenase
-
-
?
additional information
?
-