1.2.1.4: aldehyde dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about aldehyde dehydrogenase (NADP+), go to the full flat file.

Word Map on EC 1.2.1.4

Reaction

an aldehyde
+
NADP+
+
H2O
=
a carboxylate
+
NADPH
+
H+

Synonyms

AKR1A4, aldehyde dehydrogenase (NADP+), aldehyde dehydrogenase 3A1, aldehyde reductase, ALDH, ALDH1, ALDH3A1, AlDHPyr1147, dehydrogenase, aldehyde (nicotinamide adenine dinucleotide phosphate), Kvbeta2, NADP dependent aldehyde dehydrogenase, NADP-acetaldehyde dehydrogenase, NADP-dependent aldehyde dehydrogenase, Seegmiller enzyme

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.4 aldehyde dehydrogenase (NADP+)

Substrates Products

Substrates Products on EC 1.2.1.4 - aldehyde dehydrogenase (NADP+)

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-cyanobenzaldehyde + NADP+ + H2O
2-cyanobenzoate + NADPH + H+
show the reaction diagram
-
3% activity compared to 4-nitrobenzaldehyde
-
-
?
2-methlybutyraldehyde + NADP+ + H2O
2-methylbutanoate + NADPH + H+
show the reaction diagram
-
16% activity compared to 4-nitrobenzaldehyde
-
-
?
2-nitrobenzaldehyde + NADP+ + H2O
2-nitrobenzoate + NADPH + H+
show the reaction diagram
-
22% activity compared to 4-nitrobenzaldehyde
-
-
?
3-nitrobenzaldehyde + NADP+ + H2O
3-nitrobenzoate + NADPH + H+
show the reaction diagram
-
53% activity compared to 4-nitrobenzaldehyde
-
-
?
4-cyanobenzaldehyde + NADP+ + H2O
4-cyanobenzoate + NADPH + H+
show the reaction diagram
-
6% activity compared to 4-nitrobenzaldehyde
-
-
?
4-hydroperoxycyclophosphamide + NADP+
?
show the reaction diagram
-
low activity
-
-
?
4-hydroxy-2-nonenal + NADP+
(2E)-4-hydroxynon-2-enoate + NADPH + H+
show the reaction diagram
-
-
-
-
?
4-hydroxy-2-nonenal + NADP+ + H2O
(2E)-4-hydroxynon-2-enoate + NADPH + H+
show the reaction diagram
4-hydroxybenzaldehyde + NADP+ + H2O
4-hydroxybenzoate + NADPH + H+
show the reaction diagram
-
20% activity compared to 4-nitrobenzaldehyde
-
-
?
4-nitroacetophenone + NADP+ + H2O
?
show the reaction diagram
-
2% activity compared to 4-nitrobenzaldehyde
-
-
?
4-nitrobenzaldehyde + NADP+ + H2O
4-nitrobenzoate + NADPH + H+
show the reaction diagram
-
100% activity
-
-
?
acetaldehyde + NADP+
?
show the reaction diagram
acetaldehyde + NADP+
acetate + NADPH
show the reaction diagram
-
-
-
-
?
acetaldehyde + NADP+ + H2O
acetate + NADPH + H+
show the reaction diagram
an aldehyde + NADP+ + H2O
an acid + NADPH + H+
show the reaction diagram
benzaldehyde + NADP+
benzoate + NADPH
show the reaction diagram
benzaldehyde + NADP+
benzoate + NADPH + H+
show the reaction diagram
-
-
-
-
?
benzaldehyde + NADP+ + H2O
benzoate + NADPH + H+
show the reaction diagram
butanal + NADP+ + H2O
butanoate + NADPH + H+
show the reaction diagram
-
5% activity compared to 4-nitrobenzaldehyde
-
-
?
butanal + NADP+ + H2O
butyrate + NADPH + H+
show the reaction diagram
butyraldehyde + NAD+ + H2O
butyrate + NADH + H+
show the reaction diagram
-
-
-
-
?
butyraldehyde + NADP+ + H2O
butyrate + NADPH + H+
show the reaction diagram
-
-
-
-
?
chloroacetaldehyde + NADP+ + H2O
chloroacetate + NADPH + H+
show the reaction diagram
-
most effective substrate in the absence of Mg2+
-
-
?
crotonaldehyde + NADP+
crotonate + NADPH
show the reaction diagram
-
weak, enzyme a, b and c
-
-
?
crotonaldehyde + NADP+ + H2O
crotonate + NADPH + H+
show the reaction diagram
-
2% activity compared to 4-nitrobenzaldehyde
-
-
?
decanal + NADP+
decanoate + NADPH
show the reaction diagram
dodecanal + NADP+ + H2O
dodecanoate + NADPH + H+
show the reaction diagram
-
-
-
-
?
formaldehyde + NADP+ + H2O
formate + NADPH + H+
show the reaction diagram
glutaraldehyde + NADP+ + H2O
glutarate + NADPH + H+
show the reaction diagram
-
-
-
-
?
glyceraldehyde + NADP+
glycerate + NADPH
show the reaction diagram
-
weak, enzyme a, b and d
-
-
?
glyceraldehyde + NADP+ + H2O
glycerate + NADPH + H+
show the reaction diagram
glycolaldehyde + NADP+ + H2O
glycolate + NADPH + H+
show the reaction diagram
-
-
-
-
?
heptanal + NADP+
heptanoate + NADPH
show the reaction diagram
hexanal + NADP+
hexanoate + NADPH
show the reaction diagram
hexanal + NADP+ + H2O
hexanoate + NADPH + H+
show the reaction diagram
-
1% activity compared to 4-nitrobenzaldehyde
-
-
?
isobutanal + NADP+
isobutyrate + NADPH
show the reaction diagram
-
19% of the activity with acetaldehyde
-
-
ir
isobutyraldehyde + NADP+ + H2O
isobutyrate + NADPH + H+
show the reaction diagram
isopentanal + NADP+ + H2O
isopentanoate + NADPH + H+
show the reaction diagram
-
-
-
-
?
mafosfamide + NADP+
?
show the reaction diagram
-
low activity
-
-
?
malondialdehyde + NADP+
?
show the reaction diagram
-
poor substrate
-
-
?
methylglyoxal + NADP+ + H2O
?
show the reaction diagram
-
7% activity compared to 4-nitrobenzaldehyde
-
-
?
nonanal + NAD+ + H2O
nonanoate + NADH + H+
show the reaction diagram
-
-
-
-
r
nonanal + NADP+ + H2O
nonanoate + NADPH + H+
show the reaction diagram
-
-
-
-
r
octanal + NADP+ + H2O
octanoate + NADPH + H+
show the reaction diagram
pentanal + NADP+
pentanoate + NADPH
show the reaction diagram
phenylglyoxal + NADP+ + H2O
?
show the reaction diagram
-
3% activity compared to 4-nitrobenzaldehyde
-
-
?
propanal + NADP+ + H2O
propionate + NADPH + H+
show the reaction diagram
propionaldehyde + NADP+
propionate + NADPH + H+
show the reaction diagram
-
poor substrate
-
-
?
propionaldehyde + NADP+ + H2O
propanoate + NADPH + H+
show the reaction diagram
succinic semialdehyde + NADP+ + H2O
?
show the reaction diagram
-
5% activity compared to 4-nitrobenzaldehyde
-
-
?
tetradecanal + NADP+
tetradecanoate + NADPH
show the reaction diagram
-
-
-
-
?
trans,trans-muconaldehyde + NADP+ + H2O
trans,trans-muconic acid + NADPH + H+
show the reaction diagram
-
-
-
?
trans-2-hexenal + NADP+ + H2O
(2E)-hex-2-enoate + NADPH + H+
show the reaction diagram
trans-2-nonenal + NADP+ + H2O
(2E)-non-2-enoate + NADPH + H+
show the reaction diagram
trans-2-octenal + NADP+ + H2O
(2E)-oct-2-enoate + NADPH + H+
show the reaction diagram
tridecanal + NADP+
tridecanoate + NADPH
show the reaction diagram
-
-
-
-
?
undecanal + NADP+
undecanoate + NADPH
show the reaction diagram
-
-
-
-
?
valeraldehyde + NADP+ + H2O
pentanoate + NADPH + H+
show the reaction diagram
-
1% activity compared to 4-nitrobenzaldehyde
-
-
?
additional information
?
-