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1.2.1.41: glutamate-5-semialdehyde dehydrogenase

This is an abbreviated version!
For detailed information about glutamate-5-semialdehyde dehydrogenase, go to the full flat file.

Wordmap for 1.2.1.41

Word Map on EC 1.2.1.41 Wordmap for 1.2.1.41

Reaction

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L-glutamyl 5-phosphate
+
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NADPH
+
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H+
=
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L-glutamate 5-semialdehyde
+
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phosphate
+
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NADP+

Synonyms

Aldh18a1, ALDH4, beta-glutamylphosphate reductase, dehydrogenase, glutamate semialdehyde, gamma glutamyl semialdehyde dehydrogenase, gamma-glutamyl phosphate reductase, gamma-GPR, GGSALDH, glutamate 5-semialdehyde dehydrogenase, glutamate semialdehyde dehydrogenase, Glutamate-5-semialdehyde dehydrogenase, glutamate-gamma-semialdehyde dehydrogenase, glutamic gamma-semialdehyde dehydrogenase, glutamic-gamma-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GPR, GSA dehydrogenase, OsALDH18-1, P5CS, pyrroline 5-carboxylate dehydrogenase, pyrroline-5-carboxylate synthase, pyrroline-5-carboxylate synthetase, reductase, gamma-glutamyl phosphate

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                EC 1.2.1.411.2.1.41 glutamate-5-semialdehyde dehydrogenase

Inhibitors

Inhibitors on EC 1.2.1.41 - glutamate-5-semialdehyde dehydrogenase

for references in articles please use BRENDA:EC1.2.1.41

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3-(Phosphonoacetylamido)-L-alanine
-
competitive with respect to DL-pyrroline-5-carboxylic acid, non-competitive with respect to NADP+ and phosphate
Ba2+
-
50% inhibition at 1 mM
Co2+
-
50% inhibition at 2.5 mM
Cu2+
-
75% inhibition at 0.1 mM
Disulfiram
-
0.01 mM
iodoacetamide
-
40% inhibition at 1 mM
iodoacetate
-
15% inhibition at 1 mM
L-proline
NADPH
-
competitive with respect to all three substrates
Ni2+
-
100% inhibition at 0.1 mM
p-chloromercuribenzoate
-
100% inhibition at 1 mM