1.2.1.41: glutamate-5-semialdehyde dehydrogenase This is an abbreviated version! For detailed information about glutamate-5-semialdehyde dehydrogenase, go to the full flat file .
Reaction
L-glutamyl 5-phosphate +
NADPH +
H+ =
L-glutamate 5-semialdehyde +
phosphate +
NADP+
Synonyms Aldh18a1, ALDH4, beta-glutamylphosphate reductase, dehydrogenase, glutamate semialdehyde, gamma glutamyl semialdehyde dehydrogenase, gamma-glutamyl phosphate reductase, gamma-GPR, GGSALDH, glutamate 5-semialdehyde dehydrogenase, glutamate semialdehyde dehydrogenase, Glutamate-5-semialdehyde dehydrogenase, glutamate-gamma-semialdehyde dehydrogenase, glutamic gamma-semialdehyde dehydrogenase, glutamic-gamma-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GPR, GSA dehydrogenase, OsALDH18-1, P5CS, pyrroline 5-carboxylate dehydrogenase, pyrroline-5-carboxylate synthase, pyrroline-5-carboxylate synthetase, reductase, gamma-glutamyl phosphate
ECTree
Natural Substrates Products
Natural Substrates Products on EC 1.2.1.41 - glutamate-5-semialdehyde dehydrogenase
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L-5-glutamyl phosphate + NADPH
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L-glutamate 5-semialdehyde + phosphate + NAD+
L-glutamyl 5-phosphate + NADH + H+
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L-glutamate 5-semialdehyde + phosphate + NADP+
L-glutamyl 5-phosphate + NADPH + H+
additional information
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ALDH superfamily represents a group of enzymes that catalyze the oxidation of endogenous and exogenous aldehydes to the corresponding carboxylic acids
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L-5-glutamyl phosphate + NADPH
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second enzyme in pathway of proline biosynthesis
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L-5-glutamyl phosphate + NADPH
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gamma-glutamyl kinase (the first enzyme of proline biosynthetic pathway) and gamma-glutamyl phosphate reductase (second enzyme) form a complex which stabilizes the labile intermediate i.e. gamma-glutamyl phosphate
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L-glutamate 5-semialdehyde + phosphate + NADP+
L-glutamyl 5-phosphate + NADPH + H+
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L-glutamate 5-semialdehyde + phosphate + NADP+
L-glutamyl 5-phosphate + NADPH + H+
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r
L-glutamate 5-semialdehyde + phosphate + NADP+
L-glutamyl 5-phosphate + NADPH + H+
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r
L-glutamate 5-semialdehyde + phosphate + NADP+
L-glutamyl 5-phosphate + NADPH + H+
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L-glutamate 5-semialdehyde + phosphate + NADP+
L-glutamyl 5-phosphate + NADPH + H+
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L-glutamate 5-semialdehyde + phosphate + NADP+
L-glutamyl 5-phosphate + NADPH + H+
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r