1.2.1.47: 4-trimethylammoniobutyraldehyde dehydrogenase

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For detailed information about 4-trimethylammoniobutyraldehyde dehydrogenase, go to the full flat file.

Reaction

Synonyms

4-N-trimethylaminobutyraldehyde dehydrogenase, 4-N-trimethylaminobutyraldehyde dehydrogenase II, 4-trimethylaminobutyraldehyde dehydrogenase, 4-trimethylammoniobutyraldehyde dehydrogenase, aldehyde dehydrogenase 9A1, Aldh9a1, carnitine biosynthesis enzyme, dehydrogenase, trimethylaminobutyraldehyde, gamma-trimethylaminobutyraldehyde dehydrogenase, TMABA dehydrogenase, TMABA-DH, TMABADH, TMABAL dehydrogenase, TMABaldehyde-DH II, TMABALDH

ECTree

     1 Oxidoreductases

         1.2 Acting on the aldehyde or oxo group of donors

             1.2.1 With NAD⁺ or NADP⁺ as acceptor

                1.2.1.47 4-trimethylammoniobutyraldehyde dehydrogenase

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Results	in table
1	Activating Compound
30	AA Sequence
1	Application
1	CAS Registry Number
5	Cloned(Commentary)
16	Cofactor
2	Crystallization (Commentary)
9	Disease/ Diagnostics
3	Expression
6	General Information
1	General Stability
44	Inhibitors
5	Ki Value [mM]
36	KM Value [mM]
8	Localization
1	Metals/Ions
9	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
19	Organism
5	Pathway
30	PDB ID
6	pH Optimum
1	pH Range
2	pH Stability
2	pI Value
7	Purification (Commentary)
1	Reaction
4	Reaction Type
18	Reference
54	Source Tissue
16	Specific Activity [micromol/min/mg]
3	Storage Stability
69	Substrates and Products (Substrate)
11	Subunits
36	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
3	Temperature Stability [°C]

Cloned

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Cloned on EC 1.2.1.47 - 4-trimethylammoniobutyraldehyde dehydrogenase

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

expressed in Escherichia coli DH5alpha and BL21 (DE3) cells

Pseudomonas sp.

N0DT23

726537

expression in Escherichia coli

Rattus norvegicus

Q9JLJ3

288255

gene ALDH9A1, recombinant expression of His-tagged enzyme in Escherichia coli strain Rosetta2 (DE3) pLysS

Homo sapiens

P49189

762831

recombinant expression of FLAG-tagged enzyme TMABA-DH in HEK-293T cells

Homo sapiens

P49189

743576

recombinant expression of SUMO-His6-tagged ALDH9A1 in Escherichia coli strain BL21(DE3)

Homo sapiens

P49189

762675