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1.2.1.47: 4-trimethylammoniobutyraldehyde dehydrogenase

This is an abbreviated version!
For detailed information about 4-trimethylammoniobutyraldehyde dehydrogenase, go to the full flat file.

Word Map on EC 1.2.1.47

Reaction

4-Trimethylammoniobutanal
+
NAD+
 +
H2O
=
4-Trimethylammoniobutanoate
 +
NADH
 + 2 H+

Synonyms

4-N-trimethylaminobutyraldehyde dehydrogenase, 4-N-trimethylaminobutyraldehyde dehydrogenase II, 4-trimethylaminobutyraldehyde dehydrogenase, 4-trimethylammoniobutyraldehyde dehydrogenase, aldehyde dehydrogenase 9A1, Aldh9a1, carnitine biosynthesis enzyme, dehydrogenase, trimethylaminobutyraldehyde, gamma-trimethylaminobutyraldehyde dehydrogenase, TMABA dehydrogenase, TMABA-DH, TMABADH, TMABAL dehydrogenase, TMABaldehyde-DH II, TMABALDH

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.47 4-trimethylammoniobutyraldehyde dehydrogenase

Inhibitors

Inhibitors on EC 1.2.1.47 - 4-trimethylammoniobutyraldehyde dehydrogenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
-
1 mM causes 5% inhibition at 30°C
3-methylbutyraldehyde
-
1 mM causes 57% inhibition at 30°C
4-(dimethylamino)butyraldehyde
-
-
4-(trimethylamino)butyraldehyde
-
-
4-chloromercuribenzoate
-
4-guanidinobutyraldehyde
-
4-N-trimethylaminobutyraldehyde
-
the substrate inhibits at 0.24 mM
5,5'-dithiobis-(2-nitrobenzoic acid)
acetaldehyde
-
1 mM causes 18% inhibition at 30°C
Betaine aldehyde
-
1 mM causes 41% inhibition at 30°C
diethylaminobenzaldehyde
DEAB, the broad-spectrum ALDH inhibitor reversibly inhibits ALDH9A1 in a time-dependent manner by a covalent reversible mechanism of inhibition, mechanism analysis, overview
diethylmethylamine
-
at 30°C, 5 mM causes 53% inhibition, does not inhibit at 1 mM
dimethylethylamine
-
5 mM causes 9% inhibition at 30°C
Disulfiram
ethylmethylamine
-
1 mM causes 20% inhibition at 30°C
glyceraldehyde
-
1 mM causes 7% inhibition at 30°C
iodoacetoamide
KCl
-
1 mM causes 5% inhibition at 30°C
N,N,N-trimethyl-3-aminopropionaldehyde
-
p-chloromercuribenzoate
-
0.1 mM causes 88% inhibition at 30°C
phenylacetaldehyde
-
0.1 mM causes 54% inhibition at 30°C
Semicarbazide
triethylamine
-
5 mM causes 42% inhibition at 30°C
trimethylacetaldehyde
-
1 mM causes 80% inhibition at 30°C
additional information
-