1.2.1.47: 4-trimethylammoniobutyraldehyde dehydrogenase
This is an abbreviated version!
For detailed information about 4-trimethylammoniobutyraldehyde dehydrogenase, go to the full flat file.
Word Map on EC 1.2.1.47
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1.2.1.47
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gamma-butyrobetaine
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proliferator-activated
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dioxygenase
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peroxisome
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l-carnitine
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polyunsaturated
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1.2.1.8
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badhs
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aldh4a1
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suckling
-
gill
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betaine
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acetaldehyde
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trimethyllysine
- 1.2.1.47
- gamma-butyrobetaine
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proliferator-activated
-
dioxygenase
- peroxisome
- l-carnitine
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polyunsaturated
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1.2.1.8
-
badhs
-
aldh4a1
-
suckling
-
gill
- betaine
- acetaldehyde
- trimethyllysine
Reaction
Synonyms
4-N-trimethylaminobutyraldehyde dehydrogenase, 4-N-trimethylaminobutyraldehyde dehydrogenase II, 4-trimethylaminobutyraldehyde dehydrogenase, 4-trimethylammoniobutyraldehyde dehydrogenase, aldehyde dehydrogenase 9A1, Aldh9a1, carnitine biosynthesis enzyme, dehydrogenase, trimethylaminobutyraldehyde, gamma-trimethylaminobutyraldehyde dehydrogenase, TMABA dehydrogenase, TMABA-DH, TMABADH, TMABAL dehydrogenase, TMABaldehyde-DH II, TMABALDH
ECTree
1.2.1.47 4-trimethylammoniobutyraldehyde dehydrogenaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 1.2.1.47 - 4-trimethylammoniobutyraldehyde dehydrogenase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3-aminopropionaldehyde + NAD+ + H2O
3-aminopropionate + NADH + H+
-
-
-
?
3-guanidinopropionaldehyde + NAD+ + H2O
3-guanidinopropionate + NADH + H+
-
-
-
?
4-(dimethylamino)butyraldehyde + NAD+ + H2O
4-(dimethylamino)butyrate + NADH + 2 H+
-
-
-
?
4-(trimethylamino)butyraldehyde + NAD+ + H2O
4-(trimethylamino)butyrate + NADH + 2 H+
preferred substrate
-
-
?
4-amino-2-hydroxybutyraldehyde + NAD+ + H2O
4-amino-2-hydroxybutyrate + NADH + H+
-
-
-
?
4-guanidinobutyraldehyde + NAD+ + H2O
4-guanidinobutyrate + NADH + H+
-
-
-
?
4-trimethylaminobutyraldehyde + NADP+ + H2O
4-trimethylaminobutyrate + NADPH + H+
-
-
-
r
gamma-aminobutyraldehyde + NAD+ + H2O
4-aminobutanoate + NADH + H+
-
-
-
?
N,N,N-trimethyl-3-aminopropionaldehyde + NAD+ + H2O
N,N,N-trimethyl-3-aminopropionate + NADH + H+
-
-
-
?
N,N-dimethyl-3-aminopropionaldehyde + NAD+ + H2O
N,N-dimethyl-3-aminopropionate + NADH + H+
-
-
-
?
trimethylaminobutyraldehyde + NAD+ + H2O
gamma-butyrobetaine + NADH + 2 H+
enzyme is involved in L-carnitine (3-hydroxy-4-N-trimethylaminobutyrate) biosynthesis
-
-
?
3,4-dihydroxyphenylacetaldehyde + NAD+ + H2O
3,4-dihydroxyphenylacetate + NADH + H+
-
-
-
?
3,4-dihydroxyphenylacetaldehyde + NAD+ + H2O
3,4-dihydroxyphenylacetate + NADH + H+
-
-
-
-
?
3,4-dihydroxyphenylacetaldehyde + NAD+ + H2O
3,4-dihydroxyphenylacetate + NADH + H+
a dopamine metabolite
-
-
?
4-dimethylaminobutyraldehyde + NAD+
4-dimethylaminobutanoate + NADH
-
-
-
-
?
4-dimethylaminobutyraldehyde + NAD+
4-dimethylaminobutanoate + NADH
-
-
-
-
?
4-N-trimethylaminobutyraldehyde + NAD+
4-N-trimethylaminobutanoate + NADH
-
-
-
-
?
4-N-trimethylaminobutyraldehyde + NAD+
4-N-trimethylaminobutanoate + NADH
-
-
-
-
?
4-N-trimethylaminobutyraldehyde + NAD+ + H2O
gamma-butyrobetaine + NADH + H+
-
-
-
?
4-N-trimethylaminobutyraldehyde + NAD+ + H2O
gamma-butyrobetaine + NADH + H+
-
-
-
?
4-N-trimethylaminobutyraldehyde + NAD+ + H2O
gamma-butyrobetaine + NADH + H+
-
-
-
?
4-trimethylaminobutyraldehyde + NAD+
4-trimethylaminobutanoate + NADH + H+
-
-
-
-
?
4-trimethylaminobutyraldehyde + NAD+
4-trimethylaminobutanoate + NADH + H+
-
-
-
-
?
4-trimethylaminobutyraldehyde + NAD+
4-trimethylaminobutyrate + NADH + H+
-
-
-
?
4-trimethylaminobutyraldehyde + NAD+
4-trimethylaminobutyrate + NADH + H+
-
function in carnitine biosynthesis
-
?
4-trimethylaminobutyraldehyde + NAD+
4-trimethylaminobutyrate + NADH + H+
-
-
?
4-trimethylaminobutyraldehyde + NAD+
4-trimethylaminobutyrate + NADH + H+
-
-
?
4-trimethylaminobutyraldehyde + NAD+ + H2O
4-N-trimethylaminobutyrate + NADH + H+
strongly preferred substrate
-
-
?
4-trimethylaminobutyraldehyde + NAD+ + H2O
4-N-trimethylaminobutyrate + NADH + H+
a carnitine precursor
-
-
?
4-trimethylammoniobutanal + NAD+ + H2O
4-trimethylammoniobutanoate + NADH + 2 H+
-
-
-
-
?
4-trimethylammoniobutanal + NAD+ + H2O
4-trimethylammoniobutanoate + NADH + 2 H+
-
-
-
?
4-trimethylammoniobutanal + NAD+ + H2O
4-trimethylammoniobutanoate + NADH + 2 H+
-
-
-
-
?
4-trimethylammoniobutanal + NAD+ + H2O
4-trimethylammoniobutanoate + NADH + 2 H+
-
-
-
?
aminobutyraldehyde + NAD+ + H2O
aminobutyrate + NADH + H+
a GABA precursor
-
-
?
gamma-aminobutyraldehyde + NAD+
gamma-aminobutyrate + NADH
-
-
?
gamma-aminobutyraldehyde + NAD+
gamma-aminobutyrate + NADH
-
-
?
additional information
?
-
ALDH9A1 exhibits wide substrate specificity to aminoaldehydes, aliphatic and aromatic aldehydes with a clear preference for gamma-trimethylaminobutyraldehyde (TMABAL). The enzyme is multifunctional also catalyzing the reactions of EC 1.2.1.3 and EC 1.2.1.19. Substrate specificity, overview
-
-
-
additional information
?
-
-
ALDH9A1 exhibits wide substrate specificity to aminoaldehydes, aliphatic and aromatic aldehydes with a clear preference for gamma-trimethylaminobutyraldehyde (TMABAL). The enzyme is multifunctional also catalyzing the reactions of EC 1.2.1.3 and EC 1.2.1.19. Substrate specificity, overview
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-
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additional information
?
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diethylaminobenzaldehyde (DEAB) is not a substrate for ALDH9A1
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-
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additional information
?
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diethylaminobenzaldehyde (DEAB) is not a substrate for ALDH9A1
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-
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additional information
?
-
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does not degradate 4-trimethylaminobutanol, betaine aldehyde, 4-aminobutyraldehyde, acetaldehyde, propionaldehyde, butyraldehyde, trimethylacetaldehyde, and 3-methylbutyraldehyde
-
-
?
additional information
?
-
no activity with NADP+, trimethylaminobutanol, 3-N-trimethylaminopropionaldehyde, betaine aldehyde, 4-aminobutyraldehyde, and other aliphatic aldehydes such as acetaldehyde, propionaldehyde, butyraldehyde, pivaleraldehyde, isovaleraldehyde, butyraldehyde, trimethylacetaldehyde, and 3-methylbutyraldehyde
-
-
?
additional information
?
-
-
no activity with NADP+, trimethylaminobutanol, 3-N-trimethylaminopropionaldehyde, betaine aldehyde, 4-aminobutyraldehyde, and other aliphatic aldehydes such as acetaldehyde, propionaldehyde, butyraldehyde, pivaleraldehyde, isovaleraldehyde, butyraldehyde, trimethylacetaldehyde, and 3-methylbutyraldehyde
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-
?
additional information
?
-
-
does not degradate 4-trimethylaminobutanol, betaine aldehyde, 4-aminobutyraldehyde, acetaldehyde, propionaldehyde, butyraldehyde, trimethylacetaldehyde, and 3-methylbutyraldehyde
-
-
?
additional information
?
-
no activity with NADP+, trimethylaminobutanol, 3-N-trimethylaminopropionaldehyde, betaine aldehyde, 4-aminobutyraldehyde, and other aliphatic aldehydes such as acetaldehyde, propionaldehyde, butyraldehyde, pivaleraldehyde, isovaleraldehyde, butyraldehyde, trimethylacetaldehyde, and 3-methylbutyraldehyde
-
-
?
