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1.2.1.49: 2-oxoaldehyde dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about 2-oxoaldehyde dehydrogenase (NADP+), go to the full flat file.

Reaction

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a 2-oxoaldehyde
+
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NADP+
+
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H2O
=
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a 2-oxo carboxylate
+
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NADPH
+
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H+

Synonyms

2-ketoaldehyde dehydrogenase, alpha-ketoaldehyde dehydrogenase, methylglyoxal dehydrogenase, NADP-dependent alpha-ketoaldehyde dehydrogenase, NADP-linked alpha-ketoaldehyde dehydrogenase

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                EC 1.2.1.491.2.1.49 2-oxoaldehyde dehydrogenase (NADP+)

Activating Compound

Activating Compound on EC 1.2.1.49 - 2-oxoaldehyde dehydrogenase (NADP+)

for references in articles please use BRENDA:EC1.2.1.49

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-amino-2-methylpropan-1-ol
-
activation of aldehyde oxidation
2-amino-2-methylpropane-1,3-diol
-
activation of aldehyde oxidation
2-Aminobutan-1-ol
-
activation of aldehyde oxidation
2-aminopropane
-
activation of aldehyde oxidation
2-aminopropane-1,3-diol
-
activation of aldehyde oxidation
Amines
-
several amines stimulate activity
D,L-2-amino-1-propanol
-
activation of aldehyde oxidation
DL-2-amino-1-propanol
-
required, best activator of the reaction
L-2-Aminopropan-1-ol
L-serine methyl ester
-
activation of aldehyde oxidation
Tris
-
activation of aldehyde oxidation