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1.2.1.49: 2-oxoaldehyde dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about 2-oxoaldehyde dehydrogenase (NADP+), go to the full flat file.

Reaction

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a 2-oxoaldehyde
+
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NADP+
+
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H2O
=
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a 2-oxo carboxylate
+
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NADPH
+
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H+

Synonyms

2-ketoaldehyde dehydrogenase, alpha-ketoaldehyde dehydrogenase, methylglyoxal dehydrogenase, NADP-dependent alpha-ketoaldehyde dehydrogenase, NADP-linked alpha-ketoaldehyde dehydrogenase

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                EC 1.2.1.491.2.1.49 2-oxoaldehyde dehydrogenase (NADP+)

Inhibitors

Inhibitors on EC 1.2.1.49 - 2-oxoaldehyde dehydrogenase (NADP+)

for references in articles please use BRENDA:EC1.2.1.49

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
barbiturates
-
-
-
dihydroxyacetone
-
-
glycine buffer
-
complete blockage of the reaction
hydrazine
-
1-3 mM
N-ethylmaleimide
-
1-3 mM
N-tris(hydroxymethyl)methylglycine
-
-
Nitro-alcohols
-
-
-
p-hydroxymercuribenzoate
-
1-3 mM
Sodium bisulfite
-
1 mM
Sodium cyanide
-
1 mM