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1.2.1.49: 2-oxoaldehyde dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about 2-oxoaldehyde dehydrogenase (NADP+), go to the full flat file.

Reaction

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a 2-oxoaldehyde
+
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NADP+
+
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H2O
=
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a 2-oxo carboxylate
+
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NADPH
+
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H+

Synonyms

2-ketoaldehyde dehydrogenase, alpha-ketoaldehyde dehydrogenase, methylglyoxal dehydrogenase, NADP-dependent alpha-ketoaldehyde dehydrogenase, NADP-linked alpha-ketoaldehyde dehydrogenase

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                EC 1.2.1.491.2.1.49 2-oxoaldehyde dehydrogenase (NADP+)

Reference

Reference on EC 1.2.1.49 - 2-oxoaldehyde dehydrogenase (NADP+)

for references in articles please use BRENDA:EC1.2.1.49

Please use the Reference Search for a specific query.

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ray, S.; Ray, M.
Purification and characterization of NAD and NADP-linked alpha-ketoaldehyde dehydrogenases involved in catalyzing the oxidation of methylglyoxal to pyruvate
J. Biol. Chem.
257
10566-10570
1982
Capra hircus
Manually annotated by BRENDA team
Ray, M.; Ray, S.
On the interaction of nucleotides and glycolytic intermediates with NAD-linked alpha-ketoaldehyde dehydrogenase
J. Biol. Chem.
257
10571-10574
1982
Capra hircus
Manually annotated by BRENDA team
Dunkerton, J.; James, S.P.
Some observations on the NADP+-linked oxidation of methylglyoxal catalysed by 2-Oxoaldehyde dehydrogenase
Biochem. J.
153
503-504
1976
Ovis aries
Manually annotated by BRENDA team
Dunkerton, J.; James, S.P.
Purification of 2-oxoaldehyde dehydrogenase and its dependence on unusual amines
Biochem. J.
149
609-617
1975
Ovis aries
Manually annotated by BRENDA team
Jellum, E.
Metabolism of the ketoaldehyde 2-keto-3-deoxyglucose
Biochim. Biophys. Acta
165
357-363
1968
Ovis aries, Rattus norvegicus
Manually annotated by BRENDA team
Monder, C.
alpha-Keto aldehyde dehydrogenase, an enzyme that catalyzes the enzymic oxidation of methylglyoxal to pyruvate
J. Biol. Chem.
242
4603-4609
1967
Ovis aries
Manually annotated by BRENDA team
Bender, K.; Seibert, R.T.; Wienker, T.F.; Kren, V.; Pravenec, M.; Bissbort, S.
Biochemical genetics of methylglyoxal dehydrogenases in the laboratory rat (Rattus norvegicus)
Biochem. Genet.
32
147-154
1994
Rattus norvegicus
Manually annotated by BRENDA team
Vander Jagt, D.L.
2-Ketoaldehyde dehydrogenase from rat liver
Methods Enzymol.
89
513-515
1982
Rattus norvegicus
Manually annotated by BRENDA team
Vander Jagt, D.L.; Davidson, L.M.
Purification and characterization of 2-oxoaldehyde dehydrogenase from rat liver
Biochim. Biophys. Acta
484
260-267
1977
Rattus norvegicus
Manually annotated by BRENDA team
Vander Jagt, D.L.; Hunsaker, L.A.
Methylglyoxal metabolism and diabetic complications: roles of aldose reductase, glyoxalase-I, betaine aldehyde dehydrogenase and 2-oxoaldehyde dehydrogenase
Chem. Biol. Interact.
143-144
341-351
2003
Homo sapiens
Manually annotated by BRENDA team