1.2.1.61: 4-hydroxymuconic-semialdehyde dehydrogenase

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For detailed information about 4-hydroxymuconic-semialdehyde dehydrogenase, go to the full flat file.

Reaction

Synonyms

4-HS dehydrogenase, 4-hydroxymuconic semialdehyde dehydrogenase, gamma-hydroxymuconic semialdehyde dehydrogenase, hAPE, HqdC, NAD dependent gamma-hydroxymuconic semialdehyde dehydrogenase, PdcG, pnpE

ECTree

     1 Oxidoreductases

         1.2 Acting on the aldehyde or oxo group of donors

             1.2.1 With NAD⁺ or NADP⁺ as acceptor

                1.2.1.61 4-hydroxymuconic-semialdehyde dehydrogenase

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Results

in table

5

AA Sequence

2

Application

3

Cloned(Commentary)

4

Cofactor

1

Crystallization (Commentary)

9

Engineering

2

Expression

6

General Information

2

Inhibitors

12

Metals/Ions

3

Molecular Weight [Da]

2

Natural Substrates/ Products (Substrates)

16

Organism

4

Pathway

2

pH Optimum

1

pH Range

1

pH Stability

2

Purification (Commentary)

2

Reaction

3

Reaction Type

8

Reference

1

Source Tissue

4

Specific Activity [micromol/min/mg]

8

Substrates and Products (Substrate)

1

Subunits

19

Synonyms

1

Systematic Name

2

Temperature Optimum [�C]

1

Temperature Range [�C]

1

Temperature Stability [�C]

Cofactor

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Cofactor on EC 1.2.1.61 - 4-hydroxymuconic-semialdehyde dehydrogenase

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COFACTOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

NAD+

4 entries

NAD+

Pseudomonas fluorescens

-

-

687422

NAD+

Pseudomonas sp.

-

-

719179

NAD+

Moraxella sp.

-

can not be replaced by NADP+, NADH or NADPH

288304

NAD+

Pseudomonas sp. WBC-3

C1I208

NAD+ is situated in a cleft of PnpE. The cofactor binding site is composed of two pockets. The adenosine and the first ribose group of NAD bind in one pocket and the nicotinamide ring in the other. Six amino acids, C281, E247, Q210, W148, I146 and K172, interact with the cofactor

742206