1.2.1.64: 4-hydroxybenzaldehyde dehydrogenase (NAD+)
This is an abbreviated version!
For detailed information about 4-hydroxybenzaldehyde dehydrogenase (NAD+), go to the full flat file.
Word Map on EC 1.2.1.64
Reaction
Synonyms
4-hydroxybenzaldehyde dehydrogenase, HBD, p-hydroxybenzaldehyde dehydrogenase
ECTree
1.2.1.64 4-hydroxybenzaldehyde dehydrogenase (NAD+)Advanced search results
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results (Substrates Products
Substrates Products on EC 1.2.1.64 - 4-hydroxybenzaldehyde dehydrogenase (NAD+)
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-hydroxybenzaldehyde + NAD+ + H2O
2-hydroxybenzoate + NADH + 2 H+
-
12.3% relative activity compared to 4-hydroxybenzaldehyde conversion
-
-
?
2-methoxybenzaldehyde + NAD+ + H2O
2-methoxybenzoate + NADH + 2 H+
-
4.8% relative activity compared to 4-hydroxybenzaldehyde conversion, 2-methoxybenzaldehyde i.e. o-anisaldehyde
2-methoxybenzoate i.e. o-anisic acid
-
?
3-hydroxybenzaldehyde + NAD+ + H2O
3-hydroxybenzoate + NADH + 2 H+
-
27.4% relative activity compared to 4-hydroxybenzaldehyde conversion
-
-
?
4-hydroxy-3-methoxybenzaldehyde + NAD+ + H2O
4-hydroxy-3-methoxybenzoate + NADH + 2 H+
-
1% relative activity compared to 4-hydroxybenzaldehyde conversion, 4-hydroxy-3-methoxybenzaldehyde i.e. vanillin
4-hydroxy-3-methoxybenzoate i.e. vanillic acid
-
?
4-hydroxybenzaldehyde + FAD + H2O
4-hydroxybenzoate + FADH2 + ?
-
17.6% relative activity compared to reaction with NAD+
-
-
?
4-hydroxybenzaldehyde + FMN + H2O
4-hydroxybenzoate + FMNH2 + ?
-
11.5% relative activity compared to reaction with NAD+
-
-
?
4-hydroxybenzaldehyde + NADP+ + H2O
4-hydroxybenzoate + NADPH + 2 H+
-
70.4% relative activity compared to reaction with NAD+
-
-
?
benzaldehyde + NAD+ + H2O
benzoate + NADH + 2 H+
-
5.8% relative activity compared to 4-hydroxybenzaldehyde conversion
-
-
?
cinnamaldehyde + NAD+ + H2O
cinnamic acid + NADH + 2 H+
-
6.13% relative activity compared to 4-hydroxybenzaldehyde conversion
-
-
?
additional information
?
-
-
no activity with 3,4-dihydroxybenzaldehyde i.e. protocatechuic aldehyde and 3,4,5-trihydroxybenzaldehyde
-
-
?
2-hydroxybenzaldehyde + NAD+ + H2O
2-hydroxybenzoate + NADH + H+
-
very low activity
-
?
2-hydroxybenzaldehyde + NAD+ + H2O
2-hydroxybenzoate + NADH + H+
-
very low activity
-
?
3-hydroxybenzaldehyde + NAD+ + H2O
3-hydroxybenzoate + NADH + H+
-
48% of the activity compared to 4-hydroxybenzaldehyde
-
?
3-hydroxybenzaldehyde + NAD+ + H2O
3-hydroxybenzoate + NADH + H+
-
48% of the activity compared to 4-hydroxybenzaldehyde
-
?
4-hydroxybenzaldehyde + NAD+ + H2O
4-hydroxybenzoate + NADH + 2 H+
-
preferred substrate, rapid increase in 4-hydroxybenzoic acid accumulation in Daucus carota hairy root cultures detectable between 15 and 25 days after subculture preceded by an increase in 4-hydroxybenzaldehyde dehydrogenase activity
-
-
ir
4-hydroxybenzaldehyde + NAD+ + H2O
4-hydroxybenzoate + NADH + H+
-
involved in the degradation pathway of p-cresol
-
?
4-hydroxybenzaldehyde + NAD+ + H2O
4-hydroxybenzoate + NADH + H+
-
best substrate tested, non beta-oxidative pathway rather than beta-oxidation
-
?
4-hydroxybenzaldehyde + NAD+ + H2O
4-hydroxybenzoate + NADH + H+
-
best substrate tested, non beta-oxidative pathway rather than beta-oxidation
-
?
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
-
37.5% of the activity compared to 4-hydroxybenzaldehyde
-
?
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
-
37.5% of the activity compared to 4-hydroxybenzaldehyde
-
?
vanillin + NAD+ + H2O
vanillate + NADH
-
12.7% of the activity compared to 4-hydroxybenzaldehyde
-
?
vanillin + NAD+ + H2O
vanillate + NADH
-
12.7% of the activity compared to 4-hydroxybenzaldehyde
-
?
