1.2.1.71: succinylglutamate-semialdehyde dehydrogenase

This is an abbreviated version!
For detailed information about succinylglutamate-semialdehyde dehydrogenase, go to the full flat file.

Reaction

N-succinyl-L-glutamate 5-semialdehyde
+
NAD+
+
H2O
=
N-succinyl-L-glutamate
+
NADH
+ 2 H+

Synonyms

aruD, AstD, N-succinylglutamate 5-semialdehyde dehydrogenase, SGSD, succinic semialdehyde dehydrogenase, succinylglutamic semialdehyde dehydrogenase

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.71 succinylglutamate-semialdehyde dehydrogenase

Systematic Name

Systematic Name on EC 1.2.1.71 - succinylglutamate-semialdehyde dehydrogenase

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SYSTEMATIC NAME
IUBMB Comments
N-succinyl-L-glutamate 5-semialdehyde:NAD+ oxidoreductase
This is the fourth enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine [1]. This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC 2.3.1.109 (arginine N-succinyltransferase), EC 3.5.3.23 (N-succinylarginine dihydrolase), EC 2.6.1.11 (acetylornithine transaminase), EC 1.2.1.71 (succinylglutamate-semialdehyde dehydrogenase) and EC 3.5.1.96 (succinylglutamate desuccinylase) [3,6].