1.2.1.80: long-chain acyl-[acyl-carrier-protein] reductase

This is an abbreviated version!
For detailed information about long-chain acyl-[acyl-carrier-protein] reductase, go to the full flat file.

Reaction

Synonyms

AAR, acyl-ACP reductase, acyl-acyl carrier protein (acyl-ACP) reductase, acyl-acyl carrier protein reductase, AtFAR6, CpFAS1 acyl reductase, CpFAS1-R, DPW, fatty acyl-ACP reductase, fatty aldehyde-generating acyl-ACP reductase, Npun_R1710, sll0209

ECTree

     1 Oxidoreductases

         1.2 Acting on the aldehyde or oxo group of donors

             1.2.1 With NAD⁺ or NADP⁺ as acceptor

                1.2.1.80 long-chain acyl-[acyl-carrier-protein] reductase

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Results

in table

618

AA Sequence

1

Application

9

Cloned(Commentary)

11

Cofactor

2

Crystallization (Commentary)

13

Engineering

5

General Information

3

Inhibitors

5

KM Value [mM]

1

Localization

4

Metals/Ions

10

Natural Substrates/ Products (Substrates)

48

Organism

2

Pathway

8

PDB ID

1

pH Range

4

Purification (Commentary)

1

Reaction

15

Reference

8

Source Tissue

27

Substrates and Products (Substrate)

4

Subunits

37

Synonyms

1

Systematic Name

1

Temperature Stability [°C]

3

Turnover Number [1/s]

General Information

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General Information on EC 1.2.1.80 - long-chain acyl-[acyl-carrier-protein] reductase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

metabolism

Cryptosporidium parvum

-

C-terminal CpFAS1-R enzyme belongs to a multifunctional Type I fatty acid synthase, CpFAS1, with at least 21 enzymatic domains, this megasynthase is predicted to function as a fatty acyl elongase

724655

physiological function

4 entries

physiological function

Nostoc punctiforme

B2J1M0

enzyme and aldehyde-deformylating oxygenase ADO form a tight isolable complex with a Kd of 3 microM. When the aldehyde substrate is supplied to ADO by acyl-acyl carrier protein reductase, efficient in vitro turnover is observed in the absence of solubilizing agents. Catalysis by acyl-acyl carrier protein reductase proceeds via formation of a covalent intermediate involving residue C294. The enzyme specifically transfers the pro-R hydride of NADPH to the Cys294-thioester intermediate to afford its aldehyde product

740064

physiological function

Synechococcus elongatus

Q54765

the enzyme is involved in an alkane biosynthesis pathway. It forms a complex with aldehyde-deformylating oxygenase that efficiently converts long chain fatty acyl-ACP/fatty acyl-CoA into hydrocarbon

763498

physiological function

Nostoc punctiforme ATCC 29133

-

enzyme and aldehyde-deformylating oxygenase ADO form a tight isolable complex with a Kd of 3 microM. When the aldehyde substrate is supplied to ADO by acyl-acyl carrier protein reductase, efficient in vitro turnover is observed in the absence of solubilizing agents. Catalysis by acyl-acyl carrier protein reductase proceeds via formation of a covalent intermediate involving residue C294. The enzyme specifically transfers the pro-R hydride of NADPH to the Cys294-thioester intermediate to afford its aldehyde product

-

physiological function

Synechococcus elongatus PCC 7942

-

the enzyme is involved in an alkane biosynthesis pathway. It forms a complex with aldehyde-deformylating oxygenase that efficiently converts long chain fatty acyl-ACP/fatty acyl-CoA into hydrocarbon

-