1.2.1.84: alcohol-forming fatty acyl-CoA reductase This is an abbreviated version! For detailed information about alcohol-forming fatty acyl-CoA reductase, go to the full flat file .
Reaction
a long-chain acyl-CoA +
2 NADPH
+
2 H+
=
a long-chain alcohol +
2 NADP+
+
CoA
Synonyms alcohol-forming FAR, alcohol-forming fatty acyl-CoA reductase, CER4, CG1443, FACR, FAR, FAR1, FAR10, FAR11, FAR12, FAR13, FAR14, FAR15, FAR16, FAR17, FAR2, FAR3, FAR4, FAR5, FAR6, FAR7, FAR8, FAR9, fatty acyl coenzyme A reductase, fatty acyl-CoA reductase, fatty acyl-CoA reductase 1, fatty acyl-CoA reductase 3, fatty acyl-CoA:NADPH oxidoreductase (long chain alcohol forming), fatty acyl-Coenzyme A reductase, FcrA, intestinal acyl-CoA reductase, male sterility C-terminal domain, male sterility domain-containing protein 1, Maqu_2220, Maqu_2507, Ms25, peroxisomal fatty acyl-CoA reductase 1, PsFAR I, PsFAR II, RS30405, wat, Waterproof
ECTree
Natural Substrates Products
Natural Substrates Products on EC 1.2.1.84 - alcohol-forming fatty acyl-CoA reductase
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a long-chain acyl-CoA + 2 NADPH + 2 H+
a long-chain alcohol + 2 NADP+ + CoA
Marinobacter nauticus
-
-
-
?
a long-chain acyl-CoA + 2 NADPH + 2 H+
a long-chain alcohol + 2 NADP+ + coenzyme A
docosanoyl-CoA + 2 NADPH + 2 H+
1-docosanol + CoA + 2 NADP+
-
-
-
-
?
eicosanoyl-CoA + 2 NADPH + 2 H+
1-eicosanol + CoA + 2 NADP+
-
-
-
-
?
hexacosanoyl-CoA + 2 NADPH + 2 H+
hexacosanoyl alcohol + 2 NADP+ + coenzyme A
-
-
-
?
hexacosanoyl-CoA + 2 NADPH + 2 H+
hexacosanoyl alcohol + CoA + 2 NADP+
-
-
-
-
?
tetracosanoyl-CoA + 2 NADPH + 2 H+
tetracosanoyl alcohol + 2 NADP+ + coenzyme A
-
-
-
?
additional information
?
-
Waterproof is a Drosophila FAR with a preference for very long chain, saturated fatty acids of 24 and 26 carbons. In yeast cultures expressing Waterproof, tetracosanoyl-alcohol (24:0-OH) and hexacosanoyl-alcohol (26:0-OH) are identified by GC/MS analysis, unsaturated alcohols or alcohols of shorter chain-lengths are either absent or below the detection limit. Neither of these fatty alcohols is detected in the vector control yeast culture or the wat gene containing culture grown under non-inducing conditions
-
-
?
a long-chain acyl-CoA + 2 NADPH + 2 H+
a long-chain alcohol + 2 NADP+ + coenzyme A
-
-
-
?
a long-chain acyl-CoA + 2 NADPH + 2 H+
a long-chain alcohol + 2 NADP+ + coenzyme A
Marinobacter nauticus
-
-
-
?
a long-chain acyl-CoA + 2 NADPH + 2 H+
a long-chain alcohol + 2 NADP+ + coenzyme A
-
-
-
?
a long-chain acyl-CoA + 2 NADPH + 2 H+
a long-chain alcohol + 2 NADP+ + coenzyme A
-
-
-
?