1.2.1.88: L-glutamate gamma-semialdehyde dehydrogenase This is an abbreviated version! For detailed information about L-glutamate gamma-semialdehyde dehydrogenase, go to the full flat file .
Reaction
L-glutamate 5-semialdehyde +
NAD+ +
H2O =
L-glutamate +
NADH +
H+
Synonyms 1-pyrroline dehydrogenase, aldehyde dehydrogenase 12, ALDH12, Aldh4a1, dehydrogenase, 1-pyrroline-5-carboxylate, DELTA1-pyrroline-5-carboxylate dehydrogenase, delta1-pyrroline-5-carboxylate synthetase, DR_0813, EC 1.5.1.12, GSAL dehydrogenase, GSALDH, l-glutamate-gamma-semialdehyde dehydrogenase, L-pyrroline-5-carboxylate-NAD+ oxidoreductase, LRRP Ba1-651, NAD+-dependent glutamate gamma-semialdehyde dehydrogenase, OsALDH12, OsALDH18-2, P5C dehydrogenase, P5C synthase, P5C-DH, P5CD, P5CDH, P5CDH1, P5CS, PDH, PpALDH12, proline/P5C dehydrogenase, Put2, PutA, pyrroline-5-carboxylate dehydrogenase, pyrroline-5-carboxylate synthase, pyrroline-5-carboxylic acid dehydrogenase, Tc00.1047053510943.50, YcgN, ZmALDH12
ECTree
Inhibitors
Inhibitors on EC 1.2.1.88 - L-glutamate gamma-semialdehyde dehydrogenase
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([[(3,5-dibromophenyl)methyl]amino]methylene)bis(phosphonic acid)
-
inhibits the growth of rapeseed seedlings and cultured cells with a strong reduction in glutamate and glutamate-related amino acid pools, but a milder effect on free proline. Toxic delta1-pyrroline-5-carboxylate levels accumulate in treated seedlings
-
([[(3,5-dichlorophenyl)methyl]amino]methylene)bis(phosphonic acid)
-
inhibits the growth of rapeseed seedlings and cultured cells, with a strong reduction in glutamate and glutamate-related amino acid pools, but a milder effect on free proline
-
4,5-Dehydro-L-pipecolic acid
-
baikiain, competitive
cis-4-hydroxy-D-proline
weak inhibitor
Co2+
-
both isoforms, concentration above 3 mM
DELTA1-pyrroline-2-carboxylate
-
-
iodoacetamide
-
both isoforms
L-arginine
-
uncompetitive
NADH
-
product inhibition
ornithine
-
inhibits only the short enzyme form
trans-4-hydroxy-D-proline
weak inhibitor
trans-4-hydroxy-L-proline
weak inhibitor
4-aminobutyrate
-
-
4-aminobutyrate
-
both isoforms
ADP
-
-
ADP
-
3 mM, 14% inhibition of isoform A and 16% inhibition of isoform B
AMP
-
-
AMP
-
3 mM, 33% inhibition of isoform A and 11% inhibition of isoform B
arsenite
-
-
ATP
-
-
ATP
-
inhibits isoform B by 33%, but not isoform A
chloride
-
-
Cu2+
-
-
EDTA
-
-
Gly
-
-
L-Ala
-
-
L-Asp
-
no inhibition
L-Glu
-
no inhibition
L-Glu
-
very weak inhibitor
L-His
-
no inhibition
L-hydroxyproline
-
-
L-hydroxyproline
-
both isoforms, potent inhibition
L-Ile
-
no inhibition
L-Leu
-
-
L-Ser
-
-
L-Trp
-
no inhibition
L-Val
-
-
N-ethylmaleimide
-
no inhibition
p-hydroxymercuribenzoate
-
-
p-hydroxymercuribenzoate
-
both isoforms, potent inhibition
p-hydroxymercuribenzoate
-
-
sulfate
-
-
Zn2+
-
both isoforms
additional information
-
no inhibition: Ca2+, Mn2+, Mg2+, Ba2+, Pb2+, N-ethylmaleimide, o-phenanthroline
-
additional information
-
no inhibition: amino acids
-
additional information
not inhibitory: malonate
-
additional information
-
not inhibitory: malonate
-
additional information
-
no inhibition: amino acids
-
additional information
-
no inhibition: amino acids
-
additional information
cis-4-hydroxy-L-proline does not inhibit the enzyme activity
-
additional information
-
no effect of proline on activity
-
additional information
-
no inhibition: amino acids
-