1.2.1.88: L-glutamate gamma-semialdehyde dehydrogenase
This is an abbreviated version!
For detailed information about L-glutamate gamma-semialdehyde dehydrogenase, go to the full flat file.
Reaction
+
+
=
+
+
Synonyms
1-pyrroline dehydrogenase, aldehyde dehydrogenase 12, ALDH12, Aldh4a1, dehydrogenase, 1-pyrroline-5-carboxylate, DELTA1-pyrroline-5-carboxylate dehydrogenase, delta1-pyrroline-5-carboxylate synthetase, DR_0813, EC 1.5.1.12, GSAL dehydrogenase, GSALDH, l-glutamate-gamma-semialdehyde dehydrogenase, L-pyrroline-5-carboxylate-NAD+ oxidoreductase, LRRP Ba1-651, NAD+-dependent glutamate gamma-semialdehyde dehydrogenase, OsALDH12, OsALDH18-2, P5C dehydrogenase, P5C synthase, P5C-DH, P5CD, P5CDH, P5CDH1, P5CS, PDH, PpALDH12, proline/P5C dehydrogenase, Put2, PutA, pyrroline-5-carboxylate dehydrogenase, pyrroline-5-carboxylate synthase, pyrroline-5-carboxylic acid dehydrogenase, Tc00.1047053510943.50, YcgN, ZmALDH12
ECTree
KI Value
KI Value on EC 1.2.1.88 - L-glutamate gamma-semialdehyde dehydrogenase
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2 - 8
cis-4-hydroxy-D-proline
3 - 3.75
gamma-aminobutyrate
0.27
glyoxylate
pH 7.0, 20°C
3.75 - 4.75
hydroxyproline
12
L-glutamate
pH 7.0, 20°C
30
L-glutarate
pH 7.0, 20°C
58
succinate
pH 7.0, 20°C
4.5 - 10
trans-4-hydroxy-D-proline
7 - 27
trans-4-hydroxy-L-proline
2 - 5
cis-4-hydroxy-D-proline
mixed-type inhibition model, at pH 7.5, temperature not specified in the publication
8
cis-4-hydroxy-D-proline
competitive inhibition model, at pH 7.5, temperature not specified in the publication
1.5
D-proline
competitive inhibition model, at pH 7.5, temperature not specified in the publication
4.5
D-proline
uncompetitive inhibition model, at pH 7.5, temperature not specified in the publication
3
gamma-aminobutyrate
-
isoform B
3.75
gamma-aminobutyrate
-
isoform A
3.4
glutamate
-
isoform B
3.75
hydroxyproline
-
isoform B
4.75
hydroxyproline
-
isoform A
11
L-proline
competitive inhibition model, at pH 7.5, temperature not specified in the publication
19
L-proline
uncompetitive inhibition model, at pH 7.5, temperature not specified in the publication
0.6
NADH
-
product inhibition, with NAD+
0.77
NADH
-
product inhibition, with 1-pyrroline-5-carboxylate
2.5
proline
-
isoform B
4.5
trans-4-hydroxy-D-proline
competitive inhibition model, at pH 7.5, temperature not specified in the publication
10
trans-4-hydroxy-D-proline
mixed-type inhibition model, at pH 7.5, temperature not specified in the publication
7
trans-4-hydroxy-L-proline
competitive inhibition model, at pH 7.5, temperature not specified in the publication
27
trans-4-hydroxy-L-proline
mixed-type inhibition model, at pH 7.5, temperature not specified in the publication