1.2.1.9: glyceraldehyde-3-phosphate dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about glyceraldehyde-3-phosphate dehydrogenase (NADP+), go to the full flat file.

Word Map on EC 1.2.1.9

Reaction

D-glyceraldehyde 3-phosphate
+
NADP+
+
H2O
=
3-phospho-D-glycerate
+
NADPH
+ 2 H+

Synonyms

apo-GAPDH, apo-glyceraldehyde-3-phosphate dehydrogenase, dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate), E268A-GAPN, GAP dehydrogenase, GAPDH, GAPDH (A4), GAPDHN, GAPN, glyceraldehyde 3-phosphate dehydrogenase, glyceraldehyde 3-phosphate dehydrogenase (NADP), glyceraldehyde 3-phosphate:NADP+ reductase, non-phosphorylating, glyceraldehyde phosphate dehydrogenase (NADP), glyceraldehyde-3-phosphate dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase (NADP+), Glyceraldehyde-3-phosphate dehydrogenase [NADP+], glyceraldehyde-3-phosphate:NADP reductase, NADP+-dependent GAPDH, NADP+-dependent glyceraldehyde 3-phosphate dehydrogenase, NADP+-GAPDH, NADP-dependent glyceraldehyde-3-phosphate dehydrogenase, NADP-dependent nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase, NADP-glyceraldehyde phosphate dehydrogenase, NADP-glyceraldehyde-3-phosphate dehydrogenase, NADPH-dependent GAPDH, NADPH-glyceraldehyde-3-phosphate dehydrogenase, non phosphorylating glyceraldehyde-3-phosphate dehydrogenase, non-phosphorylating GAP dehydrogenase, Non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase, non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase, non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase GAPN, non-phosphorylating NADP+-dependent Ga3PDHase, non-phosphorylating NADP+-dependent glyceraldehyde-3-phosphate dehydrogenase, non-phosphorylating NADP-dependent glyceraldehyde-3-phosphate dehydrogenase, nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase, nonphosphorylating NADP-dependent glyceraldehyde-3-phosphate dehydrogenase, NP-Ga3PDHase, NP-GAPDH, OsALDH11, SSO3194, St-GAPN, STK_24770, triose phosphate dehydrogenase, Triosephosphate dehydrogenase

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.9 glyceraldehyde-3-phosphate dehydrogenase (NADP+)

Inhibitors

Inhibitors on EC 1.2.1.9 - glyceraldehyde-3-phosphate dehydrogenase (NADP+)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3-aminopyridine
-
competitive
3-phosphohydroxypyruvate
beta-Glycerophosphate
-
competitive
chloroplast protein CP12
-
the chloroplast protein CP12 behaves as a negative regulator of GAPDH activity
-
CP-12 protein
-
-
-
D-3-phosphoglycerate
D-erythrose 4-phosphate
D-glyceraldehyde 3-phosphate
-
substrate inhibition
D-Glyceraldehyde-3-phosphate
-
-
D-ribose 5-phosphate
-
-
Diamide
diphosphate
-
after interaction with the 14-3-3 regulatory protein the phosphorylated enzyme exhibits higher sensitivity to inhibition
DL-alpha-glycerophosphate
-
competitive
DL-glyceraldehyde
-
competitive
galactonate
slight inhibition; slight inhibition (1.2 to 1.3fold); slight inhibition (1.2 to 1.3fold)
gluconate
slight inhibition
hydrazin
-
protonated and neutral form, compete with the attacking water molecule for the binding site E268, inhibition mechanism
hydroxylamine
-
protonated and neutral form, compete with the attacking water molecule for the binding site E268, inhibition mechanism
iodoacetamide
L-alpha-glycerophosphate
-
competitive
L-Glyceraldehyde 3-phosphate
NADPH
phosphate
-
-
Phosphoglycolate
sedoheptulose 7-phosphate
-
-
sodium nitroprusside
-
-
Thionicotinamide
-
competitive
additional information
-