1.2.1.9: glyceraldehyde-3-phosphate dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about glyceraldehyde-3-phosphate dehydrogenase (NADP+), go to the full flat file.

Word Map on EC 1.2.1.9

Reaction

D-glyceraldehyde 3-phosphate
+
NADP+
+
H2O
=
3-phospho-D-glycerate
+
NADPH
+ 2 H+

Synonyms

apo-GAPDH, apo-glyceraldehyde-3-phosphate dehydrogenase, dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate), E268A-GAPN, GAP dehydrogenase, GAPDH, GAPDH (A4), GAPDHN, GAPN, glyceraldehyde 3-phosphate dehydrogenase, glyceraldehyde 3-phosphate dehydrogenase (NADP), glyceraldehyde 3-phosphate:NADP+ reductase, non-phosphorylating, glyceraldehyde phosphate dehydrogenase (NADP), glyceraldehyde-3-phosphate dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase (NADP+), Glyceraldehyde-3-phosphate dehydrogenase [NADP+], glyceraldehyde-3-phosphate:NADP reductase, NADP+-dependent GAPDH, NADP+-dependent glyceraldehyde 3-phosphate dehydrogenase, NADP+-GAPDH, NADP-dependent glyceraldehyde-3-phosphate dehydrogenase, NADP-dependent nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase, NADP-glyceraldehyde phosphate dehydrogenase, NADP-glyceraldehyde-3-phosphate dehydrogenase, NADPH-dependent GAPDH, NADPH-glyceraldehyde-3-phosphate dehydrogenase, non phosphorylating glyceraldehyde-3-phosphate dehydrogenase, non-phosphorylating GAP dehydrogenase, Non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase, non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase, non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase GAPN, non-phosphorylating NADP+-dependent Ga3PDHase, non-phosphorylating NADP+-dependent glyceraldehyde-3-phosphate dehydrogenase, non-phosphorylating NADP-dependent glyceraldehyde-3-phosphate dehydrogenase, nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase, nonphosphorylating NADP-dependent glyceraldehyde-3-phosphate dehydrogenase, NP-Ga3PDHase, NP-GAPDH, OsALDH11, SSO3194, St-GAPN, STK_24770, triose phosphate dehydrogenase, Triosephosphate dehydrogenase

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.9 glyceraldehyde-3-phosphate dehydrogenase (NADP+)

Reference

Reference on EC 1.2.1.9 - glyceraldehyde-3-phosphate dehydrogenase (NADP+)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rumpho, M.E.; Edwards, G.E.; Loescher, W.H.
A pathway for photosynthetic carbon flow to mannitol in celery leaves
Plant Physiol.
73
869-873
1983
Apium graveolens
Manually annotated by BRENDA team
Iglesias, A.A.; Losada, M.
Purification and kinetic and structural properties of spinach leaf NADP-dependent nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase
Arch. Biochem. Biophys.
260
830-840
1988
Spinacia oleracea
Manually annotated by BRENDA team
Iglesias, A.A.; Serrano, A.; Guerrro, M.G.; Losada, M.
Purification and properties of NADP-dependent non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase from the green algae Chlamydomonas reinhardtii
Biochim. Biophys. Acta
925
1-10
1987
Chlamydomonas reinhardtii
-
Manually annotated by BRENDA team
Pupillo, P.; Faggiani, R.
Subunit structure of three glyceraldehyde 3-phosphate dehydrogenases of some flowering plants
Arch. Biochem. Biophys.
194
581-592
1979
Arum italicum, Beta vulgaris, Ficaria verna, Spinacia oleracea
Manually annotated by BRENDA team
Kelly, G.J.; Gibbs, M.
Nonreversible D-glyceraldehyde 3-phosphate dehydrogenase of plant tissue
Plant Physiol.
52
111-118
1973
Arachis hypogaea, Pisum sativum, Ricinus communis, Zea mays
Manually annotated by BRENDA team
Jacob, J.L.; D'Auzac, J.
Glyceraldehyde-3-phosphate dehydrogenase from the latex of Hevea brasiliensis. Comparative study with its phosphorylating homologue
Eur. J. Biochem.
31
255-265
1972
Hevea brasiliensis
Manually annotated by BRENDA team
Crow, V.L.; Wittenberger, C.L.
Separation and properties of NAD+- and NADP+-dependent glyceraldehyde-3-phosphate dehydrogenases from Streptococcus mutans
J. Biol. Chem.
254
1134-1142
1979
Streptococcus mutans
Manually annotated by BRENDA team
Mann, K.H.; Mecke, D.
Inhibition of spinach glyceraldehyde-3-phosphate dehydrogenase by pentalenolactone
Nature
282
535-536
1979
Spinacia oleracea
-
Manually annotated by BRENDA team
Tamoi, M.; Ishikawa, T.; Takeda, T.; Shigeoka, S.
Enzymic and molecular characterization of NADP-dependent glyceraldehyde-3-phosphate dehydrogenase from Synechoccocus PCC 7942: resistance of the enzyme to hydrogen peroxide
Biochem. J.
316
685-690
1996
Synechococcus sp.
Manually annotated by BRENDA team
Marchal, S.; Branlant, G.
Engineered nonphosphorylating gylceraldehyde 3-phosphate dehydrogenase at position 268 binds hydroxylamine and hydrazine as acyl acceptors
Eur. J. Biochem.
268
5764-5770
2001
Streptococcus mutans
Manually annotated by BRENDA team
Charron, C.; Talfournier, F.; Isupov, M.N.; Branlant, G.; Littlechild, J.A.; Vitoux, B.; Aubry, A.
Crystallization and preliminary X-ray diffraction studies of D-glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic archaeon Methanothermus fervidus
Acta Crystallogr. Sect. D
55
1253-1255
1999
Methanothermus fervidus
-
Manually annotated by BRENDA team
Nakamura, Y.; Tada, T.; Wada, K.; Kinoshita, T.; Tamoi, M.; Shigeoka, S.; Nishimura, K.
Crystallization and preliminary X-ray diffraction analysis of NADP-dependent glyceraldehyde-3-phosphate dehydrogenase of Synechococcus PCC 7942
Acta Crystallogr. Sect. D
57
879-881
2001
Synechococcus sp.
Manually annotated by BRENDA team
Arutyunov, D.Y.; Muronetz, V.I.
The activation of glycolysis performed by the non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase in the model system
Biochem. Biophys. Res. Commun.
300
149-154
2003
Streptococcus mutans
Manually annotated by BRENDA team
Bustos, D.M.; Iglesias, A.A.
Non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase is post-translationally phosphorylated in heterotrophic cells of wheat (Triticum aestivum)
FEBS Lett.
530
169-173
2002
Triticum aestivum (Q8LK61), Triticum aestivum
Manually annotated by BRENDA team
Marchal, S.; Branlant, G.
Characterization of the amino acids involved in substrate specificity of nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase from Streptococcus mutans
J. Biol. Chem.
277
39235-39242
2002
Streptococcus mutans
Manually annotated by BRENDA team
Rahuel-Clermont, S.; Arutyunov, D.; Marchal, S.; Orlov, V.; Muronetz, V.; Branlant, G.
Thermal destabilization of non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase from Streptococcus mutans upon phosphate binding in the active site
J. Biol. Chem.
280
18590-18597
2005
Streptococcus mutans
Manually annotated by BRENDA team
Iddar, A.; Valverde, F.; Serrano, A.; Soukri, A.
Purification of recombinant non-phosphorylating NADP-dependent glyceraldehyde-3-phosphate dehydrogenase from Streptococcus pyogenes expressed in E. coli
Mol. Cell. Biochem.
247
195-203
2003
Streptococcus pyogenes
Manually annotated by BRENDA team
Bustos, D.M.; Iglesias, A.A.
Phosphorylated non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase from heterotrophic cells of wheat interacts with 14-3-3 proteins
Plant Physiol.
133
2081-2088
2003
Triticum aestivum
Manually annotated by BRENDA team
Iglesias, A.A.; Vicario, L.R.; Gomez-Casati, D.F.; Sesma, J.I.; Gomez-Casati, M.E.; Bustos, D.M.; Podesta, F.E.
On the interaction of substrate analogues with non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase from celery leaves
Plant Sci.
162
689-696
2002
Apium graveolens
-
Manually annotated by BRENDA team
Iddar, A.; Valverde, F.; Serrano, A.; Soukri, A.
Expression, purification, and characterization of recombinant nonphosphorylating NADP-dependent glyceraldehyde-3-phosphate dehydrogenase from Clostridium acetobutylicum
Protein Expr. Purif.
25
519-526
2002
Clostridium acetobutylicum
Manually annotated by BRENDA team
Kitatani, T.; Nakamura, Y.; Wada, K.; Kinoshita, T.; Tamoi, M.; Shigeoka, S.; Tada, T.
Structure of apo-glyceraldehyde-3-phosphate dehydrogenase from Synechococcus PCC7942
Acta crystallogr. Sect. F
62
727-730
2006
Synechococcus elongatus PCC 7942 = FACHB-805
Manually annotated by BRENDA team
DAmbrosio, K.; Pailot, A.; Talfournier, F.; Didierjean, C.; Benedetti, E.; Aubry, A.; Branlant, G.; Corbier, C.
The first crystal structure of a thioacylenzyme intermediate in the ALDH family: new coenzyme conformation and relevance to catalysis
Biochemistry
45
2978-2986
2006
Streptococcus mutans (Q59931)
Manually annotated by BRENDA team
Lebreton, S.; Andreescu, S.; Graciet, E.; Gontero, B.
Mapping of the interaction site of CP12 with glyceraldehyde-3-phosphate dehydrogenase from Chlamydomonas reinhardtii. Functional consequences for glyceraldehyde-3-phosphate dehydrogenase
FEBS J.
273
3358-3369
2006
Chlamydomonas reinhardtii
Manually annotated by BRENDA team
Asanuma, N.; Hino, T.
Presence of NADP+-specific glyceraldehyde-3-phosphate dehydrogenase and CcpA-dependent transcription of its gene in the ruminal bacterium Streptococcus bovis
FEMS Microbiol. Lett.
257
17-23
2006
Streptococcus equinus (Q3C1A6)
Manually annotated by BRENDA team
Iddar, A.; Valverde, F.; Assobhei, O.; Serrano, A.; Soukri, A.
Widespread occurrence of non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase among gram-positive bacteria
Int. Microbiol.
8
251-258
2005
Bacillus cereus (Q2HQS1), Bacillus licheniformis (Q2HQS0), Bacillus sp. (in: Bacteria), Bacillus thuringiensis (Q2HQR5), Clostridioides difficile (Q2HQR4), Clostridium acetobutylicum (Q2HQR9), Clostridium pasteurianum (Q2HQR7), Clostridium perfringens (Q2HQR8), Clostridium sporogenes (Q2HQR6), Streptococcus agalactiae (Q2HQS4), Streptococcus pyogenes (Q2HQR3), Streptococcus sp. (Q2HQS3)
Manually annotated by BRENDA team
Harris, D.M.; Diderich, J.A.; van der Krogt, Z.A.; Luttik, M.A.; Raamsdonk, L.M.; Bovenberg, R.A.; van Gulik, W.M.; van Dijken, J.P.; Pronk, J.T.
Enzymic analysis of NADPH metabolism in beta-lactam-producing Penicillium chrysogenum: presence of a mitochondrial NADPH dehydrogenase
Metab. Eng.
8
91-101
2006
no activity in Penicillium chrysogenum
Manually annotated by BRENDA team
Rius, S.P.; Casati, P.; Iglesias, A.A.; Gomez-Casati, D.F.
Characterization of an Arabidopsis thaliana mutant lacking a cytosolic non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase
Plant Mol. Biol.
61
945-957
2006
Arabidopsis thaliana
Manually annotated by BRENDA team
Sparla, F.; Zaffagnini, M.; Wedel, N.; Scheibe, R.; Pupillo, P.; Trost, P.
Regulation of photosynthetic GAPDH dissected by mutants
Plant Physiol.
138
2210-2219
2005
Spinacia oleracea
Manually annotated by BRENDA team
Ettema, T.J.; Ahmed, H.; Geerling, A.C.; van der Oost, J.; Siebers, B.
The non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (GAPN) of Sulfolobus solfataricus: a key-enzyme of the semi-phosphorylative branch of the Entner-Doudoroff pathway.
Extremophiles
12
75-88
2007
Saccharolobus solfataricus (Q97U30), Saccharolobus solfataricus (Q97XA5), Saccharolobus solfataricus (Q97XS9), Saccharolobus solfataricus, Saccharolobus solfataricus P2 (Q97U30), Saccharolobus solfataricus P2 (Q97XA5), Saccharolobus solfataricus P2 (Q97XS9)
Manually annotated by BRENDA team
Wu, L.; Tang, T.; Zhou, R.; Shi, S.
PCR-mediated recombination of the amplification products of the Hibiscus tiliaceus cytosolic glyceraldehyde-3-phosphate dehydrogenase gene
J. Biochem. Mol. Biol.
40
172-179
2007
Talipariti tiliaceum
Manually annotated by BRENDA team
Bustos, D.M.; Bustamante, C.A.; Iglesias, A.A.
Involvement of non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase in response to oxidative stress
J. Plant Physiol.
165
456-461
2008
Triticum aestivum, Zea mays
Manually annotated by BRENDA team
Gao, C.; Han, B.
Evolutionary and expression study of the aldehyde dehydrogenase (ALDH) gene superfamily in rice (Oryza sativa)
Gene
431
86-94
2009
Oryza sativa (Q6Z9G0)
Manually annotated by BRENDA team
Martinez, I.; Zhu, J.; Lin, H.; Bennett, G.N.; San, K.Y.
Replacing Escherichia coli NAD-dependent glyceraldehyde 3-phosphate dehydrogenase (GAPDH) with a NADP-dependent enzyme from Clostridium acetobutylicum facilitates NADPH dependent pathways
Metab. Eng.
10
352-359
2008
Clostridium acetobutylicum
Manually annotated by BRENDA team
Guo, Z.P.; Zhang, L.; Ding, Z.Y.; Wang, Z.X.; Shi, G.Y.
Improving ethanol productivity by modification of glycolytic redox factor generation in glycerol-3-phosphate dehydrogenase mutants of an industrial ethanol yeast
J. Ind. Microbiol. Biotechnol.
38
935-943
2011
Bacillus cereus
Manually annotated by BRENDA team
Erales, J.; Mekhalfi, M.; Woudstra, M.; Gontero, B.
Molecular mechanism of NADPH-glyceraldehyde-3-phosphate dehydrogenase regulation through the C-terminus of CP12 in Chlamydomonas reinhardtii
Biochemistry
50
2881-2888
2011
Chlamydomonas reinhardtii
Manually annotated by BRENDA team
Ito, F.; Miyake, M.; Fushinobu, S.; Nakamura, S.; Shimizu, K.; Wakagi, T.
Engineering the allosteric properties of archaeal non-phosphorylating glyceraldehyde-3-phosphate dehydrogenases
Biochim. Biophys. Acta
1844
759-766
2014
Saccharolobus solfataricus (Q97U30), Saccharolobus solfataricus, Saccharolobus solfataricus P2 (Q97U30), Sulfurisphaera tokodaii (Q96XP0), Sulfurisphaera tokodaii, Sulfurisphaera tokodaii 7 (Q96XP0)
Manually annotated by BRENDA team
Avilan, L.; Maberly, S.; Mekhalfi, M.; Plateau, J.; Puppo, C.; Gontero, B.
Regulation of glyceraldehyde-3-phosphate dehydrogenase in the eustigmatophyte Pseudocharaciopsis ovalis is intermediate between a chlorophyte and a diatom
Eur. J. Phycol.
47
207-215
2012
Asterionella formosa, Chlamydomonas reinhardtii, Pseudocharaciopsis ovalis
-
Manually annotated by BRENDA team
Ito, F.; Chishiki, H.; Fushinobu, S.; Wakagi, T.
Comparative analysis of two glyceraldehyde-3-phosphate dehydrogenases from a thermoacidophilic archaeon, Sulfolobus tokodaii
FEBS Lett.
586
3097-3103
2012
Sulfurisphaera tokodaii (Q96XP0), Sulfurisphaera tokodaii, Sulfurisphaera tokodaii 7 (Q96XP0)
Manually annotated by BRENDA team
Piattoni, C.V.; Guerrero, S.A.; Iglesias, A.A.
A differential redox regulation of the pathways metabolizing glyceraldehyde-3-phosphate tunes the production of reducing power in the cytosol of plant cells
Int. J. Mol. Sci.
14
8073-8092
2013
Arabidopsis thaliana
Manually annotated by BRENDA team
Matsubara, K.; Yokooji, Y.; Atomi, H.; Imanaka, T.
Biochemical and genetic characterization of the three metabolic routes in Thermococcus kodakarensis linking glyceraldehyde 3-phosphate and 3-phosphoglycerate
Mol. Microbiol.
81
1300-1312
2011
Thermococcus kodakarensis
Manually annotated by BRENDA team
Komati Reddy, G.; Lindner, S.N.; Wendisch, V.F.
Metabolic engineering of an ATP-neutral Embden-Meyerhof-Parnas pathway in Corynebacterium glutamicum: growth restoration by an adaptive point mutation in NADH dehydrogenase
Appl. Environ. Microbiol.
81
1996-2005
2015
Clostridium acetobutylicum, Clostridium acetobutylicum (Q2HQR9)
Manually annotated by BRENDA team
Centeno-Leija, S.; Utrilla, J.; Flores, N.; Rodriguez, A.; Gosset, G.; Martinez, A.
Metabolic and transcriptional response of Escherichia coli with a NADP+-dependent glyceraldehyde 3-phosphate dehydrogenase from Streptococcus mutans
Antonie van Leeuwenhoek
104
913-924
2013
Streptococcus mutans (Q59931)
Manually annotated by BRENDA team
Arutyunov, D.; Schmalhausen, E.; Orlov, V.; Rahuel-Clermont, S.; Nagradova, N.; Branlant, G.; Muronetz, V.
An unusual effect of NADP+ on the thermostability of the nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase from Streptococcus mutans
Biochem. Cell Biol.
91
295-302
2013
Streptococcus mutans
Manually annotated by BRENDA team