1.2.1.90: glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+]

This is an abbreviated version!
For detailed information about glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+], go to the full flat file.

Reaction

D-glyceraldehyde 3-phosphate
+
NAD(P)+
+
H2O
=
3-phospho-D-glycerate
+
NAD(P)H
+ 2 H+

Synonyms

GAPN, NAD+-dependent glyceraldehyde-3-phosphate dehydrogenase, NAD+-dependent non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase, non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase, nonphosphorylating NAD+-dependent GAPN

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.90 glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+]

Cofactor

Cofactor on EC 1.2.1.90 - glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+]

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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADP+
the enzyme is able to utilize NAD+ and NADP+ as cofactor. Without activator Vmax of the NADP-dependent reaction is 40% compared to the NAD+-dependent reaction. In presence of activators (D-glucose 1-phosphate, D-fructose 6-phosphate, AMP and ADP) Vmax of the NADP+-dependent reaction increases by a factor of 3