1.2.1.90: glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+]

This is an abbreviated version!
For detailed information about glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+], go to the full flat file.

Reaction

D-glyceraldehyde 3-phosphate
+
NAD(P)+
+
H2O
=
3-phospho-D-glycerate
+
NAD(P)H
+ 2 H+

Synonyms

GAPN, NAD+-dependent glyceraldehyde-3-phosphate dehydrogenase, NAD+-dependent non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase, non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase, nonphosphorylating NAD+-dependent GAPN

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.90 glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+]

Inhibitors

Inhibitors on EC 1.2.1.90 - glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+]

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
L-Glyceraldehyde 3-phosphate
strong competitive inhibitor with respect to D-glyceraldehyde 3-phosphate
additional information
in contrast to other members of the ALDH superfamily, the enzyme from Thermoproteus tenax is regulated by a number of intermediates and metabolites. In the NAD+-dependent oxidation of D-glyceraldehyde 3-phosphate, ATP, NADP, NADPH and NADH decrease the affinity for the cosubstrate leaving, however, the catalytic rate virtually unaltered
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