1.2.3.1: aldehyde oxidase
This is an abbreviated version!
For detailed information about aldehyde oxidase, go to the full flat file.
Word Map on EC 1.2.3.1
-
1.2.3.1
-
xanthine
-
molybdenum
-
allopurinol
-
oxidases
-
menadione
-
benzaldehyde
-
abscisic
-
n-oxide
-
n-heterocyclic
-
moco
-
phthalazine
-
raloxifene
-
molybdenum-containing
-
xanthinuria
-
hydralazine
-
oxidase-mediated
-
drug-drug
-
molybdoenzymes
-
sulphite
-
o6-benzylguanine
-
molybdopterin
-
flavin-containing
-
disulfiram
-
n1-methylnicotinamide
-
oxypurinol
-
nutrition
-
medicine
-
hypouricemia
-
amidoxime
-
oxidase-catalyzed
-
pharmacology
-
synthesis
-
degradation
-
cyp2a6
-
nitroreduction
-
imidacloprid
-
neonicotinoids
-
phenanthridine
- 1.2.3.1
- xanthine
- molybdenum
- allopurinol
- oxidases
- menadione
- benzaldehyde
-
abscisic
- n-oxide
-
n-heterocyclic
- moco
- phthalazine
- raloxifene
-
molybdenum-containing
-
xanthinuria
- hydralazine
-
oxidase-mediated
-
drug-drug
-
molybdoenzymes
- sulphite
- o6-benzylguanine
- molybdopterin
-
flavin-containing
- disulfiram
- n1-methylnicotinamide
- oxypurinol
- nutrition
- medicine
-
hypouricemia
-
amidoxime
-
oxidase-catalyzed
- pharmacology
- synthesis
- degradation
- cyp2a6
-
nitroreduction
- imidacloprid
-
neonicotinoids
- phenanthridine
Reaction
Synonyms
Aao4, AHO2, aldehyde oxidase 1, aldehyde oxidase 2, aldehyde oxidase 3, aldehyde oxidase 3-like 1, aldehyde oxidase 4, aldehyde-oxygen oxidoreductase, aldehyde:oxygen oxidoreductase, ALOD, AlOx, antennae-specific aldehyde oxidase, AO, AO-alpha, AO-beta, AO-delta, AO-gamma, AO-kappa, AO1, AO2, AO3, AO4, AOH, AOH1, AOH2, AOH3, AOMM, AOR, AOX, AOX1, AOX2, AOX3, AOX4, AtraAOX2, EC 1.2.3.11, FOD, formate oxidase, IAO1, mAOX3, mouse liver aldehyde oxidase 3, quinoline oxidase, Retinal oxidase, retinene oxidase
ECTree
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Substrates Products
Substrates Products on EC 1.2.3.1 - aldehyde oxidase
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REACTION DIAGRAM
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta-[d]-pyrimidine + H2O + O2
?
-
i.e. (S)-RS-8359
-
-
?
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine + H2O + O2
?
-
i.e. (S)-RS-8359
-
-
?
(+)-biotin (+)-sulfoxide methyl ester + acetaldehyde + H2O
?
-
under anaerobic conditions
-
-
?
(+/-)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta-[d]-pyrimidine + H2O + O2
?
-
i.e. RS-8359
-
-
?
(1S)-camphor oxime + H2O + 2-hydroxypyrimidine
(1S)-camphor + (1S)-camphor imine + NH3
-
other electron acceptors are N-methylnicotinamide, butyraldehyde and benzaldehyde
the corresponding ketimine is an intermediate
?
(S)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine + H2O + O2
? + H2O2
-
i.e. S-8359
-
-
?
(Z)-11-hexadecenal + H2O + O2
(Z)-11-hexadecenoic acid + H2O2
-
-
-
-
?
(Z)-9-tetradecenal + H2O + O2
(Z)-9-tetradecenoic acid + H2O2
-
-
-
-
?
1-methoxy-2-naphthaldehyde + H2O + O2
1-methoxy-2-naphthoic acid + H2O2
-
-
-
-
?
1-naphthaldehyde + H2O + O2
1-naphthalene carboxylic acid + H2O2
-
-
-
?
2,4-dihydroxybenzaldehyde + H2O + O2
2,4-dihydroxybenzoate + H2O2
-
-
-
?
2-fluoro-N-methyl-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide + H2O + O2
?
-
i.e. c-met inhibitor capmatinib
-
-
?
2-methyl-E-2-butenal + H2O + O2
2-methyl-E-2-butenoic acid + H2O2
-
-
-
?
2-[(6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinolin-3-yl)amino]ethan-1-ol + H2O + O2
? + H2O2
3 brimonidine + 4 H2O + 4 O2
2-oxobrimonidine + 3-oxobrimonidine + 2,3-dioxobrimonidine + 4 H2O2
3,4-dihydroxybenzaldehyde + H2O + O2
3,4-dihydroxybenzoate + H2O2
-
38.2% of the rate with benzaldehyde
-
-
?
3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine N-oxide + electron donor
3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine + an electron acceptor
-
electron donors are 2-hydroxypyrimidine, N1-methylnicotinamide, benzaldehyde or butyraldehyde under anaerobic conditions
-
-
?
3-methoxy-2-naphthaldehyde + H2O + O2
3-methoxy-2-naphthoic acid + H2O2
-
-
-
-
?
3-methoxy-4-hydroxybenzaldehyde + H2O + O2
3-methoxy-4-hydroxybenzoate + H2O2
-
-
-
-
?
4-(dimethylamino)cinnamaldehyde + H2O + O2
4-(dimethylamino)cinnamic acid + H2O2
-
-
-
?
4-(dimethylamino)cinnamaldehyde + nitrite + H2O + O2
? + nitric oxide
-
in the presence of typical aldehyde substrates like 4-(dimethylamino)cinnamaldehyde or NADH, aldehyde oxidase reduces nitrite to nitric oxide
-
-
?
4-hydroxyl-2-nonenal + H2O + O2
4-hydroxy-2-nonenoate + H2O2
-
-
-
?
4-hydroxypyrazolo(3,4-d)pyrimidine + O2 + H2O
4,6-dihydroxypyrazolo(3,4-d)pyrimidine + H2O2
4-hydroxypyrimidine + H2O + O2
?
-
ferricyanide as electron acceptor under aerobic conditions
-
-
?
4-nitrobenzaldehyde + H2O + O2
4-nitrobenzoate + H2O2
-
-
-
?
5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine + H2O + O2
?
-
i.e. brimonidine
-
-
?
5-nitroquinoline + H2O + O2
2-oxo-5-nitroquinoline + 5-aminoquinoline + 2-oxo-5-aminoquinoline
-
-
-
?
6-chloroquinazolin-4(3H)-one + H2O + O2
6-chloroquinazoline-2,4(1H,3H)-dione + H2O2
-
-
-
-
?
6-dimethyloamino-2-naphthaldehyde + H2O + O2
6-dimethylamino-2-naphthoic acid + H2O2
-
-
-
-
?
6-ethyl-5H-dibenz(c,e)azepine + H2O + O2
?
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
6-methoxy-2-naphthaldehyde + H2O + O2
6-methoxy-2-naphthoic acid + H2O2
-
-
-
-
?
6-methoxyquinazolin-4(3H)-one + H2O + O2
6-methoxyquinazoline-2,4(1H,3H)-dione + H2O2
-
-
-
-
?
6-methylquinazolin-4(3H)-one + H2O + O2
6-methylquinazoline-2,4(1H,3H)-dione + H2O2
-
-
-
-
?
6-methylthiopurine + H2O + O2
6-methylthio-8-hydroxypurine + H2O2
-
2,6-dichlorophenol indophenol can also act as electron acceptor
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxetan-3-yl)quinolin-3-amine + H2O + O2
? + H2O2
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxolan-3-yl)quinolin-3-amine + H2O + O2
? + H2O2
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-[(oxolan-3-yl)methyl]quinolin-3-amine + H2O + O2
? + H2O2
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinoline + H2O + O2
? + H2O2
7-methoxy-1-naphthaldehyde + H2O + O2
7-methoxy-2-naphthoic acid + H2O2
-
-
-
-
?
acetamiprid + H2O + O2
? + H2O2
-
i.e. (1E)-N-[(6-chloropyridin-3-yl)methyl]-N'-cyano-N-methylethanimidamide, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, little inactivation of neonicotinoid insecticide substrate
-
-
?
acrolein + H2O + O2
?
results indicate that AtraAOX2 also functions as a xenobiotic-degrading enzyme
-
-
?
allopurinol + H2O + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
-
-
-
?
anthracene-9-carboxaldehyde + H2O + O2
anthracene-9-carboxylate + H2O2
-
-
-
-
?
benzaldehyde + 2,6-dichlorophenol indophenol
?
natural electron acceptor of enzyme is molecular oxygen, DCPIP i.e., 2,6-dichlorophenol indophenol
-
-
?
benzaldehyde + H2O + 2,6-dichlorophenolindophenol
benzoate + reduced 2,6-dichlorophenolindophenol
-
-
-
?
benzamidoxime + H2O + 2-hydroxypyrimidine
benzamidine + ?
-
other electron acceptors are N-methylnicotinamide, butyraldehyde and benzaldehyde
-
-
?
BIBX1382 + H2O + O2
BIBU1476 + ?
-
high hepatic clearance of 17 to 18 ml/(min * kg)
product identification by high-resolution mass spectrometry
-
?
carbazeran + H2O + O2
carbazeran phthalazinone + ?
-
high hepatic clearance of 17 to 18 ml/(min * kg)
product identification by high-resolution mass spectrometry
-
?
chloroacetaldehyde + H2O + O2
chloroacetic acid + H2O2
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
cis-5-fluoro-2-methyl-1-[p-(methylsulfinyl)benzylindenyl]indene-3-acetic acid + electron acceptor + H2O
5-fluoro-2-methyl-1-[p-(methylthio)benzylindenyl]indene-3-acetic acid + ?
clothianidin + H2O + O2
? + H2O2
-
i.e. (2E)-2-[([(2-chloro-1,3-thiazol-5-yl)methyl]amino)(methylamino)methylene]-1-hydroxy-1-oxodiazanium, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, strong inactivation of neonicotinoid insecticide substrate
-
-
?
clothianidin + NMNH
nitroso-clothianidin + amino-clothianidin + ?
-
-
-
-
?
desmethyl-thiamethoxam + H2O + O2
? + H2O2
-
i.e. (4E)-3-[(2-chloro-1,3-thiazol-5-yl)methyl]-N-nitro-1,3,5-oxadiazinan-4-imine, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, strong inactivation of neonicotinoid insecticide substrate
-
-
?
dibenzyl sulfoxide + acetaldehyde + H2O
?
-
under anaerobic conditions
-
-
?
dinotefuran + H2O + O2
? + H2O2
-
i.e. 1-methyl-2-nitro-3-(tetrahydrofuran-3-ylmethyl)guanidine, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, strong inactivation of neonicotinoid insecticide substrate
-
-
?
E,E-2,4-decadienal + 2 H2O + 2 O2
E,E-2,4-decadienoic acid + 2 H2O2
-
-
-
?
ethyl vanillin + H2O + O2
ethyl vanillic acid + H2O2
-
-
-
?
furfural + H2O + O2
2-furoic acid + H2O2
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
glyceraldehyde + H2O + O2
2,3-dihydroxypropanoic acid + H2O2
-
ferricyanide and 2,6-dichlorophenol-indophenol as electron acceptor under aerobic conditions
-
-
?
glycoaldehyde + H2O + O2
hydroxyacetic acid + H2O2
-
ferricyanide and 2,6-dichlorophenol-indophenol as electron acceptor under aerobic conditions
-
-
?
hypoxanthine + O2 + H2O
xanthine + H2O2
-
22-26% of the activity compared to purine
-
?
imidacloprid + H2O + O2
? + H2O2
-
i.e. (2E)-1-[(6-chloropyridin-3-yl)methyl]-N-nitroimidazolidin-2-imine, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, strong inactivation of neonicotinoid insecticide substrate
-
-
?
imidacloprid + H2O + O2
nitroso-imidacloprid
-
-
without addition of an electron donor, product is nitroso-imidacloprid
-
?
imidacloprid + H2O + O2 + N-methylnicotinamide
nitroso-imidacloprid + amino-imidacloprid + H2O2 + ?
imidacloprid + NMNH
nitroso-imidacloprid + amino-imidacloprid + ?
-
-
-
-
?
imipramine N-oxide + electron donor
imipramine + electron acceptor
-
electron donors are 2-hydroxypyrimidine, N1-methylnicotinamide, benzaldehyde or butyraldehyde under anaerobic conditions
-
-
?
isobutyraldehyde + H2O + O2
isobutyric acid + H2O2
-
ferricyanide as electron acceptor under aerobic conditions
-
-
?
isovaleraldehyde + H2O + O2
isovaleric acid + H2O2
-
ferricyanide as electron acceptor under aerobic conditions
-
-
?
L-methionine sulfoxide + acetaldehyde + H2O
?
-
under anaerobic conditions
-
-
?
N-(2-(dimethylamino)ethyl)acridine-4-carboxamide + H2O + O2
N-[(2-dimethylamino)ethyl] acridine-4-carboxamide-9(10H)-acridone + H2O2
-
-
-
?
n-alkanal + H2O + O2
n-alkanoic acid + H2O2
-
C5-C10, C12, C14 with decreasing activities
-
-
?
n-heptylaldehyde + H2O + O2
heptanoate + H2O2
-
78% of activity with n-hexylaldehyde
-
-
?
N-methylimidacloprid + H2O + O2
? + H2O2
-
i.e. (2E)-1-[(6-chloropyridin-3-yl)methyl]-3-methyl-N-nitroimidazolidin-2-imine, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, little inactivation of neonicotinoid insecticide substrate
-
-
?
N-methylnicotinamide + electron acceptor + H2O
?
-
electron acceptors i.e.: dichlorophenolindophenol, nitro blue tetrazolium, ferricyanide, diaphorase activity
-
-
?
N-methylphenanthridinium + H2O + ferricyanide
N-methyl-6-phenanthridone + ferrocyanide
-
-
-
-
?
N-methylquinolinium + H2O + electron donor
N-methyl-4-quinolone and N-methyl-2-quinolone + electron acceptor
N-phenylquinolinium + H2O + electron donor
N-phenyl-4-quinolone and N-phenyl-2-quinolone + electron acceptor
N-[(2-dimethylamino)ethyl] acridine-4-carboxamide + H2O + O2
N-[(2-dimethylamino)ethyl] acridine-4-carboxamide-9(10H)-acridone + H2O2
N-[(2-dimethylamino)ethyl]acridine-4-carboxamide + H2O + O2
DACA-9(10H)-acridone + H2O2
-
N-[(2-dimethylamino)ethyl]acridine-4-carboxamide i.e. DACA, an experimental antitumor agent
-
-
?
N-[2-(dimethylamino)ethyl]acridine-4-carboxamide + H2O + O2
N-[(2-dimethylamino)ethyl] acridine-4-carboxamide-9(10H)-acridone + H2O2
-
-
-
?
N-[2-(dimethylamino)ethyl]acridine-4-carboxamide + H2O + O2
N-[2-(dimethylamino)ethyl]acridine-4-carboxamide-9-(10H)-acridone + H2O2
-
antitumor drug
-
-
?
N1-methyl-nicotineamide + H2O + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
-
-
-
?
N1-methylnicotinamide + 2,6-dichlorophenol indophenol
?
natural electron acceptor of enzyme is molecular oxygen, DCPIP i.e., 2,6-dichlorophenol indophenol
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + ?
-
variations in the ratio of the amount of pyridones to the total amount of NMN and pyridones in urine are closely related to the enzyme activity
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
N1-propylnicotinamide + H2O + O2
N1-propyl-2-pyridone-5-carboxamide + N1-propyl-4-pyridone-3-carboxamide + H2O2
NADH + nitrite + H2O + O2
? + nitric oxide
-
in the presence of typical aldehyde substrates like 4-(dimethylamino)cinnamaldehyde or NADH, aldehyde oxidase reduces nitrite to nitric oxide. NADH reacts with aldehyde oxidase at the FAD site of the enzyme
-
-
?
nitenpyram + H2O + O2
? + H2O2
-
i.e. (E)-N-[(6-chloropyridin-3-yl)methyl]-N-ethyl-N'-methyl-2-nitroethylene-1,1-diamine, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, partial inactivation of neonicotinoid insecticide substrate
-
-
?
nithiazine + H2O + O2
? + H2O2
-
i.e. (2Z)-2-(nitromethylene)-1,3-thiazinane, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, partial inactivation of neonicotinoid insecticide substrate
-
-
?
phenanthrene-9-carboxaldehyde + H2O + O2
phenanthrene-9-carboxylate + H2O2
-
-
-
-
?
phenothiazine sulfoxide + acetaldehyde + H2O
?
-
under anaerobic conditions
-
-
?
phenylpropionaldehyde + H2O + O2
phenylpropionic acid + H2O2
-
-
-
?
phthalaldehyde + H2O + O2
phthalic acid + H2O2
-
13% of activity with n-hexylaldehyde
-
-
?
phthalazine + 2,6-dichlorophenol indophenol
?
natural electron acceptor of enzyme is molecular oxygen, DCPIP i.e., 2,6-dichlorophenol indophenol
-
-
?
phthalazine + H2O + 2,6-dichlorophenol indophenol
? + reduced 2,6-dichlorophenolindophenol
-
-
-
?
protocatechualdehyde + H2O + O2
protocatechuic acid + H2O2
-
2,6-dichlorophenol-indophenol also as electron acceptor
-
-
?
purine derivative + H2O + ferricyanide
oxidized purine derivative + ?
-
various purine derivatives are listed, this enzyme catalyzes usually a ring methine group vicinal to a ring nitrogen
-
-
?
pyrazolo[3,4-d]pyrimidine + H2O + ferricyanide
oxidized pyrazolo[3,4-d]pyrimidine + ?
-
various pyrazolo[3,4-d]pyrimidines are listed, this enzyme catalyzes usually a ring methine group vicinal to a ring nitrogen
-
-
?
salicylaldoxime + H2O + 2-hydroxypyrimidine
salicylaldehyde + NH3 + ?
-
other electron acceptors are N-methylnicotinamide, butyraldehyde and benzaldehyde
the corresponding ketimine is an intermediate
?
terephthalaldehyde + H2O + O2
terephthalic acid + H2O2
-
45% of activity with n-hexylaldehyde
-
-
?
thiacloprid + H2O + O2
? + H2O2
-
i.e. ((2Z)-3-[(6-chloropyridin-3-yl)methyl]-1,3-thiazolidin-2-ylidene)cyanamide, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, little inactivation of neonicotinoid insecticide substrate
-
-
?
thiamethoxam + H2O + O2
? + H2O2
-
i.e. (4E)-3-[(2-chloro-1,3-thiazol-5-yl)methyl]-5-methyl-N-nitro-1,3,5-oxadiazinan-4-imine, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, strong inactivation of neonicotinoid insecticide substrate
-
-
?
tropylium tetrafluoroborate + H2O + ferricyanide
tropone + ?
-
other electron acceptors as dichloroindophenol and chromate
-
-
?
veratraldehyde + H2O + O2
veratric acid + H2O2
-
18% of activity with n-hexylaldehyde
-
-
?
XK-469 + H2O + O2
3-oxo-XK-469 + ?
-
hepatic clearance less than 4.3 ml/(min * kg)
product identification by high-resolution mass spectrometry
-
?
zaleplon + H2O + O2
5-oxozaleplon + ?
-
hepatic clearance less than 4.3 ml/(min * kg)
product identification by high-resolution mass spectrometry
-
?
zoniporide + H2O + O2
2-oxozoniporide + H2O2
-
i.e. 1-(quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl guanidine
-
-
?
?
enzyme shows a biphasic pattern in Eadie–Hofstee plots of the (S)-enantiospecific 2-oxidation activity of RS-8359
-
-
?
(S)-RS-8359
?
-
enzyme shows a monophasic pattern in Eadie-Hofstee plots of the (S)-enantiospecific 2-oxidation activity of RS-8359
-
-
?
2-keto-(S)-RS-8359 + H2O2
i.e. 4-([(7S)-7-hydroxy-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]amino)benzonitrile, reversible inhibitor of monoamine oxidase A. Remarkable strain differences in activity on substrate, correlating in part with expressed levels of protein
-
-
?
(S)-RS-8359 + H2O + O2
2-keto-(S)-RS-8359 + H2O2
Donryu rats show a dimorphic pattern for the 2-oxidation activity of RS-8359
-
-
?
2-ethylbutanoate + H2O2
-
51% of activity with formaldehyde
-
-
?
2-ethylbutylaldehyde + H2O + O2
2-ethylbutanoate + H2O2
-
350% of activity with formaldehyde
-
-
?
2-ethylbutylaldehyde + H2O + O2
2-ethylbutanoate + H2O2
-
170% of activity with formaldehyde
-
-
?
2-hydroxypyrimidine + H2O + O2
uracil + H2O2
-
ferricyanide as electron acceptor under aerobic conditions
-
-
?
2-hydroxypyrimidine + H2O + O2
uracil + H2O2
-
diphenylsulfoxide as electron acceptor under anaerobic conditions
-
-
?
2-methoxybenzaldehyde + H2O + O2
2-methoxybenzoate + H2O2
-
-
-
?
2-methylbenzoate + H2O2
-
7% of activity with n-hexylaldehyde
-
-
?
2-methylbenzaldehyde + H2O + O2
2-methylbenzoate + H2O2
-
7% of activity with n-hexylaldehyde
-
-
?
2-[(6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinolin-3-yl)amino]ethan-1-ol + H2O + O2
? + H2O2
-
-
-
-
?
2-[(6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinolin-3-yl)amino]ethan-1-ol + H2O + O2
? + H2O2
-
-
-
-
?
2-[(6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinolin-3-yl)amino]ethan-1-ol + H2O + O2
? + H2O2
-
-
-
-
?
2-[(6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinolin-3-yl)amino]ethan-1-ol + H2O + O2
? + H2O2
-
-
-
-
?
2-oxobrimonidine + 3-oxobrimonidine + 2,3-dioxobrimonidine + 4 H2O2
-
-
-
-
?
3 brimonidine + 4 H2O + 4 O2
2-oxobrimonidine + 3-oxobrimonidine + 2,3-dioxobrimonidine + 4 H2O2
-
-
-
-
?
3 brimonidine + 4 H2O + 4 O2
2-oxobrimonidine + 3-oxobrimonidine + 2,3-dioxobrimonidine + 4 H2O2
-
-
-
-
?
3 brimonidine + 4 H2O + 4 O2
2-oxobrimonidine + 3-oxobrimonidine + 2,3-dioxobrimonidine + 4 H2O2
-
-
-
-
?
3-hydroxypropionaldehyde + H2O + O2
3-hydroxypropionate + H2O2
-
-
-
-
?
3-methoxybenzaldehyde + H2O + O2
3-methoxybenzoate + H2O2
-
-
-
?
3-methylbenzoate + H2O2
-
42% of activity with n-hexylaldehyde
-
-
?
3-methylbenzaldehyde + H2O + O2
3-methylbenzoate + H2O2
-
42% of activity with n-hexylaldehyde
-
-
?
? + H2O2
-
i.e. RS-8359, 2-oxidation of the S-enantiomer
-
-
?
4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine + H2O + O2
? + H2O2
-
i.e. RS-8359, 2-oxidation of the S-enantiomer
-
-
?
4-(dimethylamine)cinnamate + H2O2
-
-
-
?
4-(dimethylamino)cinnamaldehyde + O2 + H2O
4-(dimethylamine)cinnamate + H2O2
-
typical substrate spectrum of aldehyde oxidase
-
?
4-(dimethylamino)cinnamaldehyde + O2 + H2O
4-(dimethylamine)cinnamate + H2O2
-
-
-
?
4-hydroxybenzaldehyde + H2O + O2
4-hydroxybenzoate + H2O2
-
-
-
?
4,6-dihydroxypyrazolo(3,4-d)pyrimidine + H2O2
-
12-13% of the activity compared to purine
-
?
4-hydroxypyrazolo(3,4-d)pyrimidine + O2 + H2O
4,6-dihydroxypyrazolo(3,4-d)pyrimidine + H2O2
-
i.e. allopurinol
-
?
4-methoxybenzaldehyde + H2O + O2
4-methoxybenzoate + H2O2
-
-
-
?
4-methylbenzoate + H2O2
-
40% of activity with n-hexylaldehyde
-
-
?
4-methylbenzaldehyde + H2O + O2
4-methylbenzoate + H2O2
-
40% of activity with n-hexylaldehyde
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxetan-3-yl)quinolin-3-amine + H2O + O2
? + H2O2
-
-
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxetan-3-yl)quinolin-3-amine + H2O + O2
? + H2O2
-
-
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxetan-3-yl)quinolin-3-amine + H2O + O2
? + H2O2
-
-
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxetan-3-yl)quinolin-3-amine + H2O + O2
? + H2O2
-
-
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxolan-3-yl)quinolin-3-amine + H2O + O2
? + H2O2
-
-
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxolan-3-yl)quinolin-3-amine + H2O + O2
? + H2O2
-
-
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxolan-3-yl)quinolin-3-amine + H2O + O2
? + H2O2
-
-
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxolan-3-yl)quinolin-3-amine + H2O + O2
? + H2O2
-
-
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-[(oxolan-3-yl)methyl]quinolin-3-amine + H2O + O2
? + H2O2
-
-
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-[(oxolan-3-yl)methyl]quinolin-3-amine + H2O + O2
? + H2O2
-
-
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-[(oxolan-3-yl)methyl]quinolin-3-amine + H2O + O2
? + H2O2
-
-
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-[(oxolan-3-yl)methyl]quinolin-3-amine + H2O + O2
? + H2O2
-
-
-
-
?
? + H2O2
-
-
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinoline + H2O + O2
? + H2O2
-
-
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinoline + H2O + O2
? + H2O2
-
-
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinoline + H2O + O2
? + H2O2
-
-
-
-
?
abscisic acid + H2O2
-
four aldehyde oxidases are known that have varying affinities to abscisic aldehyde. AOdelta, endcoded by AAO3 specifically catalyses this step in rosette leaves
-
-
?
abscisic aldehyde + H2O + O2
abscisic acid + H2O2
-
-
-
?
acetaldehyde + 2 ferricyanide + H2O
acetate + 2 ferrocyanide + 2 H+
-
-
-
-
?
acetaldehyde + 2 ferricyanide + H2O
acetate + 2 ferrocyanide + 2 H+
-
-
-
-
?
acetaldehyde + H2O + O2
acetate + H2O2
-
35% of activity with formaldehyde
-
-
?
acetaldehyde + H2O + O2
acetate + H2O2
is a poor substrate of AOH1
-
-
?
acetaldehyde + H2O + O2
acetate + H2O2
is a poor substrate of AOX1
-
-
?
acetaldehyde + H2O + O2
acetate + H2O2
-
350% of activity with formaldehyde
-
-
?
acetaldehyde + H2O + O2
acetate + H2O2
-
51% of activity with n-hexylaldehyde
-
-
?
acetaldehyde + H2O + O2
acetate + H2O2
-
51% of activity with n-hexylaldehyde
-
-
?
acetaldehyde + H2O + O2
acetate + H2O2
-
170% of activity with formaldehyde
-
-
?
acetaldehyde + H2O + O2
acetic acid + H2O2
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
acetaldehyde + H2O + O2
acetic acid + H2O2
-
ferricyanide as electron acceptor under aerobic conditions
-
-
?
acetaldehyde + H2O + O2
acetic acid + H2O2
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
acetaldehyde + H2O + O2
acetic acid + H2O2
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
acetaldehyde + H2O + O2
acetic acid + H2O2
Megalodesulfovibrio gigas
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
acetaldehyde + H2O + O2
acetic acid + H2O2
Q84IX9; Q84IY0 andQ84IX8
-
-
-
?
acetaldehyde + H2O + O2
acetic acid + H2O2
-
-
-
?
acetophenone oxime + H2O + 2-hydroxypyrimidine
acetophenone + NH3
-
-
-
-
?
acetophenone oxime + H2O + 2-hydroxypyrimidine
acetophenone + NH3
-
other electron acceptors are N-methylnicotinamide, butyraldehyde and benzaldehyde
the corresponding ketimine is an intermediate
?
acetophenone oxime + H2O + 2-hydroxypyrimidine
acetophenone + NH3
-
-
-
-
?
acrolein + H2O + O2
acrylic acid + H2O2
-
8% of activity with formaldehyde
-
-
?
acrolein + H2O + O2
acrylic acid + H2O2
-
140% of activity with formaldehyde
-
-
?
acrolein + H2O + O2
acrylic acid + H2O2
-
130% of activity with formaldehyde
-
-
?
all-trans retinoic acid + H2O2
-
-
-
?
all-trans retinaldehyde + H2O + O2
all-trans retinoic acid + H2O2
AOH1 from the liver of CD1 mice is capable of oxidizing all-trans retinaldehyde
-
-
?
all-trans retinaldehyde + H2O + O2
all-trans retinoic acid + H2O2
AOH2 from the mouse Harderian gland and AOH3 from the mouse Bowman's gland are all capable of oxidizing all-trans retinaldehyde with equal efficiency
-
-
?
all-trans retinaldehyde + H2O + O2
all-trans retinoic acid + H2O2
-
-
-
?
benzoate + 2 ferrocyanide + 2 H+
-
-
-
-
?
benzaldehyde + 2 ferricyanide + H2O
benzoate + 2 ferrocyanide + 2 H+
-
-
-
-
?
benzaldehyde + 2 ferricyanide + H2O
benzoate + 2 ferrocyanide + 2 H+
-
-
-
-
?
benzaldehyde + 2 ferricyanide + H2O
benzoate + 2 ferrocyanide + 2 H+
-
-
-
-
?
benzaldehyde + 2 ferricyanide + H2O
benzoate + 2 ferrocyanide + 2 H+
-
-
-
-
?
benzaldehyde + 2 ferricyanide + H2O
benzoate + 2 ferrocyanide + 2 H+
-
-
-
-
?
benzaldehyde + H2O + O2
benzoate + H2O2
-
130% of activity with formaldehyde
-
-
?
benzaldehyde + H2O + O2
benzoate + H2O2
-
160% of activity with formaldehyde
-
-
?
benzaldehyde + H2O + O2
benzoate + H2O2
-
41% of activity with n-hexylaldehyde
-
-
?
benzaldehyde + H2O + O2
benzoate + H2O2
-
-
-
?
benzaldehyde + H2O + O2
benzoate + H2O2
-
410% of activity with formaldehyde
-
-
?
benzaldehyde + H2O + O2
benzoic acid + H2O2
-
2,6-dichlorophenol-indophenol also as electron acceptor
-
-
?
benzaldehyde + H2O + O2
benzoic acid + H2O2
-
diphenylsulfoxide as electron acceptor under anaerobic conditions and ferricyanide and 2,6-dichlorophenol-indophenol as electron acceptor under aerobic conditions
-
-
?
benzaldehyde + H2O + O2
benzoic acid + H2O2
-
2,6-dichlorophenol-indophenol also as electron acceptor
-
-
?
benzaldehyde + H2O + O2
benzoic acid + H2O2
Q84IX9; Q84IY0 andQ84IX8
-
-
-
?
benzaldehyde + H2O + O2
benzoic acid + H2O2
-
chromate as electron acceptor
-
-
?
benzaldehyde + H2O + O2
benzoic acid + H2O2
-
2,6-dichlorophenol-indophenol also as electron acceptor
-
-
?
butanoate + 2 ferrocyanide + 2 H+
-
-
-
-
?
butanal + 2 ferricyanide + H2O
butanoate + 2 ferrocyanide + 2 H+
-
-
-
-
?
butanal + H2O + O2
butyric acid + H2O2
-
ferricyanide and 2,6-dichlorophenol-indophenol as electron acceptor under aerobic conditions
-
-
?
butanal + H2O + O2
butyric acid + H2O2
-
ferricyanide as electron donor under aerobic conditions
-
-
?
butanal + H2O + O2
butyric acid + H2O2
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
butanal + H2O + O2
butyric acid + H2O2
Q84IX9; Q84IY0 andQ84IX8
-
-
-
?
butylaldehyde + H2O + O2
butanoate + H2O2
-
31% of activity with formaldehyde
-
-
?
butylaldehyde + H2O + O2
butanoate + H2O2
-
360% of activity with formaldehyde
-
-
?
butylaldehyde + H2O + O2
butanoate + H2O2
-
260% of activity with formaldehyde
-
-
?
?
-
wild type monkey AOX1 is not able to oxidize chinchonidine, but mutant enzyme V1085A does
-
-
?
cinchonidine + H2O + O2
?
-
rabbit AOX1 has an extremely high Vmax value toward cinchonidine
-
-
?
cinnamaldehyde + H2O + O2
cinnamic acid + H2O2
-
44.2% of the rate with benzaldehyde
-
-
?
cinnamaldehyde + H2O + O2
cinnamic acid + H2O2
-
170% of activity with formaldehyde
-
-
?
cinnamaldehyde + H2O + O2
cinnamic acid + H2O2
-
-
-
?
cinnamaldehyde + H2O + O2
cinnamic acid + H2O2
-
240% of activity with formaldehyde
-
-
?
cinnamaldehyde + H2O + O2
cinnamic acid + H2O2
-
410% of activity with formaldehyde
-
-
?
cis-5-fluoro-2-methyl-1-[p-(methylsulfinyl)benzylindenyl]indene-3-acetic acid + electron acceptor + H2O
5-fluoro-2-methyl-1-[p-(methylthio)benzylindenyl]indene-3-acetic acid + ?
-
N1-methylnicotinamide and acetaldehyde as electron acceptors under anaerobic conditions
-
-
?
cis-5-fluoro-2-methyl-1-[p-(methylsulfinyl)benzylindenyl]indene-3-acetic acid + electron acceptor + H2O
5-fluoro-2-methyl-1-[p-(methylthio)benzylindenyl]indene-3-acetic acid + ?
-
N1-methylnicotinamide and acetaldehyde as electron acceptors under anaerobic conditions
-
-
?
(2E)-3,7-dimethylocta-2,6-dienoic acid + H2O2
low AtraAOX2 activity
-
-
?
citral + H2O + O2
(2E)-3,7-dimethylocta-2,6-dienoic acid + H2O2
-
-
-
?
citral + H2O + O2
(2E)-3,7-dimethylocta-2,6-dienoic acid + H2O2
-
210% of activity with formaldehyde
-
-
?
citral + H2O + O2
(2E)-3,7-dimethylocta-2,6-dienoic acid + H2O2
-
-
-
?
citral + H2O + O2
(2E)-3,7-dimethylocta-2,6-dienoic acid + H2O2
-
260% of activity with formaldehyde
-
-
?
citral + H2O + O2
(2E)-3,7-dimethylocta-2,6-dienoic acid + H2O2
-
13% of activity with n-hexylaldehyde
-
-
?
citral + H2O + O2
(2E)-3,7-dimethylocta-2,6-dienoic acid + H2O2
-
430% of activity with formaldehyde
-
-
?
crotonate + H2O2
-
-
-
?
crotonaldehyde + H2O + O2
crotonate + H2O2
-
32% of activity with n-hexylaldehyde
-
-
?
crotonic acid + H2O2
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
crotonaldehyde + H2O + O2
crotonic acid + H2O2
-
61% of activity with formaldehyde
-
-
?
crotonaldehyde + H2O + O2
crotonic acid + H2O2
-
230% of activity with formaldehyde
-
-
?
crotonaldehyde + H2O + O2
crotonic acid + H2O2
-
340% of activity with formaldehyde
-
-
?
decanoate + H2O2
-
41% of activity with formaldehyde
-
-
?
decylaldehyde + H2O + O2
decanoate + H2O2
-
52% of activity with formaldehyde
-
-
?
decylaldehyde + H2O + O2
decanoate + H2O2
-
400% of activity with formaldehyde
-
-
?
diphenyl sulfoxide + acetaldehyde + H2O
?
-
under anaerobic conditions
-
-
?
DL-glycerate + H2O2
-
28% of activity with formaldehyde
-
-
?
DL-glyceraldehyde + H2O + O2
DL-glycerate + H2O2
-
77% of activity with formaldehyde
-
-
?
DL-glyceraldehyde + H2O + O2
DL-glycerate + H2O2
-
5% of activity with n-hexylaldehyde
-
-
?
DL-glyceraldehyde + H2O + O2
DL-glycerate + H2O2
-
73% of activity with formaldehyde
-
-
?
nicotinamide + electron acceptor
-
2-hydroxypyrimidine as electron acceptor
-
-
?
electron donor + nicotinamide N-oxide
nicotinamide + electron acceptor
-
2-hydroxypyrimidine as electron acceptor
-
-
?
electron donor + nicotinamide N-oxide
nicotinamide + electron acceptor
-
2-hydroxypyrimidine as electron acceptor
-
-
?
electron donor + nicotinamide N-oxide
nicotinamide + electron acceptor
-
electron donors are 2-hydroxypyrimidine, N1-methylnicotinamide, benzaldehyde or butyraldehyde
-
-
?
electron donor + nicotinamide N-oxide
nicotinamide + electron acceptor
-
2-hydroxypyrimidine as electron acceptor
-
-
?
electron donor + nicotinamide N-oxide
nicotinamide + electron acceptor
-
2-hydroxypyrimidine as electron acceptor
-
-
?
formaldehyde + H2O + O2
formate + H2O2
-
2% of activity with n-hexylaldehyde, aldehyde oxidase might be effective for the removal of formaldehyde contained in wastewater
-
-
?
formic acid + H2O2
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
formaldehyde + H2O + O2
formic acid + H2O2
Q84IX9; Q84IY0 andQ84IX8
-
-
-
?
glutarate + H2O2
-
18% of activity with formaldehyde
-
-
?
glutaraldehyde + H2O + O2
glutarate + H2O2
-
64% of activity with formaldehyde
-
-
?
glutaraldehyde + H2O + O2
glutarate + H2O2
-
30% of activity with n-hexylaldehyde
-
-
?
glutaraldehyde + H2O + O2
glutarate + H2O2
-
20% of activity with formaldehyde
-
-
?
heptanal + H2O + O2
heptanoic acid + H2O2
-
ferricyanide and 2,6-dichlorophenol-indophenol as electron acceptor under aerobic conditions
-
-
?
heptanal + H2O + O2
heptanoic acid + H2O2
Q84IX9; Q84IY0 andQ84IX8
-
-
-
?
heptanoate + H2O2
-
76% of activity with formaldehyde
-
-
?
heptylaldehyde + H2O + O2
heptanoate + H2O2
-
350% of activity with formaldehyde
-
-
?
heptylaldehyde + H2O + O2
heptanoate + H2O2
-
480% of activity with formaldehyde
-
-
?
hexanal + H2O + O2
hexanoic acid + H2O2
Q84IX9; Q84IY0 andQ84IX8
-
-
-
?
hexanoate + H2O2
-
74% of activity with formaldehyde
-
-
?
hexylaldehyde + H2O + O2
hexanoate + H2O2
-
360% of activity with formaldehyde
-
-
?
hexylaldehyde + H2O + O2
hexanoate + H2O2
-
430% of activity with formaldehyde
-
-
?
nitroso-imidacloprid + amino-imidacloprid + H2O2 + ?
-
-
in presence of N-methylnicotinamide, ratio of amino- to nitroso-products is 2.0 to 1.8
-
?
imidacloprid + H2O + O2 + N-methylnicotinamide
nitroso-imidacloprid + amino-imidacloprid + H2O2 + ?
-
-
in presence of N-methylnicotinamide, ratio of amino- to nitroso-products is 26 to 50
-
?
imidacloprid + H2O + O2 + N-methylnicotinamide
nitroso-imidacloprid + amino-imidacloprid + H2O2 + ?
-
-
in presence of N-methylnicotinamide, ratio of amino- to nitroso-products is 80 to 41
-
?
imidacloprid + H2O + O2 + N-methylnicotinamide
nitroso-imidacloprid + amino-imidacloprid + H2O2 + ?
-
-
-
-
?
imidacloprid + H2O + O2 + N-methylnicotinamide
nitroso-imidacloprid + amino-imidacloprid + H2O2 + ?
-
-
in presence of N-methylnicotinamide, ratio of amino- to nitroso-products is 10 to 269
-
?
imidacloprid + H2O + O2 + N-methylnicotinamide
nitroso-imidacloprid + amino-imidacloprid + H2O2 + ?
-
-
-
?
imidacloprid + H2O + O2 + N-methylnicotinamide
nitroso-imidacloprid + amino-imidacloprid + H2O2 + ?
-
-
in presence of N-methylnicotinamide, ratio of amino- to nitroso-products is 23 to 14
-
?
imidacloprid + H2O + O2 + N-methylnicotinamide
nitroso-imidacloprid + amino-imidacloprid + H2O2 + ?
-
-
-
-
?
indol-3-carboxylic acid + H2O2
-
-
-
?
indol-3-carboxyaldehyde + H2O + O2
indol-3-carboxylic acid + H2O2
-
20% of activity with formaldehyde
-
-
?
indol-3-carboxyaldehyde + H2O + O2
indol-3-carboxylic acid + H2O2
-
8% of activity with formaldehyde
-
-
?
indol-3-carboxyaldehyde + H2O + O2
indol-3-carboxylic acid + H2O2
-
100% of activity with formaldehyde
-
-
?
indole 3-acetic acid + H2O2
-
48.0% of the rate with benzaldehyde
-
-
?
indole 3-acetaldehyde + H2O + O2
indole 3-acetic acid + H2O2
-
-
-
?
indole 3-acetaldehyde + H2O + O2
indole 3-acetic acid + H2O2
-
2,6-dichlorophenol-indophenol also as electron acceptor
-
-
?
indole 3-carbaldehyde + H2O + O2
indole 3-carboxylate + H2O2
-
2,6-dichlorophenol-indophenol also as electron acceptor
-
-
?
indole-3-aldehyde + H2O + O2
indole-3-carboxylate + H2O2
-
-
-
?
N-methyl-4-quinolone and N-methyl-2-quinolone + electron acceptor
-
-
-
-
?
N-methylquinolinium + H2O + electron donor
N-methyl-4-quinolone and N-methyl-2-quinolone + electron acceptor
-
electron donors are ferricyanide and cytochrome c
-
-
?
N-phenyl-4-quinolone and N-phenyl-2-quinolone + electron acceptor
-
-
-
-
?
N-phenylquinolinium + H2O + electron donor
N-phenyl-4-quinolone and N-phenyl-2-quinolone + electron acceptor
-
electron donors are ferricyanide and cytochrome c
-
-
?
N-[(2-dimethylamino)ethyl] acridine-4-carboxamide-9(10H)-acridone + H2O2
-
-
-
-
?
N-[(2-dimethylamino)ethyl] acridine-4-carboxamide + H2O + O2
N-[(2-dimethylamino)ethyl] acridine-4-carboxamide-9(10H)-acridone + H2O2
-
-
-
-
?
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
-
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
diphenylsulfoxide as electron acceptor under anaerobic conditions and ferricyanide as electron acceptor under aerobic conditions
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
-
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
-
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
-
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
-
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
potassium ferricyanide acts as electron acceptor
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
chromate as electron acceptor, reduction of chromate
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
cytochrome c reduction under aerobic conditions
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
-
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
-
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
-
-
?
N1-propyl-2-pyridone-5-carboxamide + N1-propyl-4-pyridone-3-carboxamide + H2O2
-
-
-
-
?
N1-propylnicotinamide + H2O + O2
N1-propyl-2-pyridone-5-carboxamide + N1-propyl-4-pyridone-3-carboxamide + H2O2
-
-
-
-
?
O6-benzylguanine + H2O + O2
O6-benzyl-8-oxoguanine + ?
-
hepatic clearance of 11.2 to 12.8 ml/(min * kg)
product identification by high-resolution mass spectrometry
-
?
octanoate + H2O2
-
64% of activity with formaldehyde
-
-
?
octylaldehyde + H2O + O2
octanoate + H2O2
-
350% of activity with formaldehyde
-
-
?
octylaldehyde + H2O + O2
octanoate + H2O2
-
430% of activity with formaldehyde
-
-
?
p-anisic acid + H2O2
-
40.2% of the rate with benzaldehyde
-
-
?
p-anisaldehyde + H2O + O2
p-anisic acid + H2O2
-
180% of activity with formaldehyde
-
-
?
p-anisaldehyde + H2O + O2
p-anisic acid + H2O2
-
190% of activity with formaldehyde
-
-
?
p-anisaldehyde + H2O + O2
p-anisic acid + H2O2
-
500% of activity with formaldehyde
-
-
?
p-hydroxybenzoate + H2O2
-
54.8% of the rate with benzaldehyde
-
-
?
p-hydroxybenzaldehyde + H2O + O2
p-hydroxybenzoate + H2O2
-
200% of activity with formaldehyde
-
-
?
p-hydroxybenzaldehyde + H2O + O2
p-hydroxybenzoate + H2O2
-
250% of activity with formaldehyde
-
-
?
p-hydroxybenzaldehyde + H2O + O2
p-hydroxybenzoate + H2O2
-
320% of activity with formaldehyde
-
-
?
phenanthridine + H2O + O2
6-phenantridone + H2O2
-
products are about 85-90% hydrogen peroxide and 6-10% superoxide anion
-
-
?
phenanthridine + H2O + O2
6-phenantridone + H2O2
-
oxidation of vanillin is more sensitive to inhibition by flavonoids than that of phenanthridine
-
-
?
phenanthridine + H2O + O2
?
activity of rabbit liver aldehyde oxidase characterized in nine water-miscible organic mixtures i.e. phosphate buffer mixed with N-N-dimethylformamide, acetonitrile, tetrahydrofuran, 1-propanol, 2-propanol, ethanol, pyridine, dioxane, and methanol
-
-
?
phenanthridine + H2O + O2
?
-
inhibitory effects of 15 flavonoids on the activity of rat liver aldehyde oxidase assessed, glycosylated flavonoids show relatively weaker inhibition, quantitative structure–activity relationship studies performed to elucidate the important structural properties responsible for the observed inhibitory effects
-
-
?
phenanthridine + H2O + O2
?
-
inhibitory effects of 15 flavonoids on the activity of rat liver aldehyde oxidase assessed, glycosylated flavonoids show relatively weaker inhibition, quantitative structure–activity relationship studies performed to elucidate the important structural properties responsible for the observed inhibitory effects
-
-
?
phenanthridinone + H2O2
-
-
-
?
phenylacetate + H2O2
-
26% of activity with formaldehyde
-
-
?
phenylacetaldehyde + H2O + O2
phenylacetate + H2O2
-
130% of activity with formaldehyde
-
-
?
phenylacetaldehyde + H2O + O2
phenylacetate + H2O2
-
230% of activity with formaldehyde
-
-
?
phenylacetic acid + H2O2
-
ferricyanide as electron acceptor under aerobic conditions
-
-
?
phenylacetaldehyde + H2O + O2
phenylacetic acid + H2O2
-
-
-
?
phenylacetaldehyde + H2O + O2
phenylacetic acid + H2O2
-
-
-
?
phenylacetaldehyde + H2O + O2
phenylacetic acid + H2O2
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
phthalazine + H2O + O2
1-phthalazinone + H2O2
-
-
-
?
propanoic acid + H2O2
highest AtraAOX2 activity
-
-
?
propionaldehyde + H2O + O2
propionate + H2O2
-
23% of activity with formaldehyde
-
-
?
propionaldehyde + H2O + O2
propionate + H2O2
-
340% of activity with formaldehyde
-
-
?
propionaldehyde + H2O + O2
propionate + H2O2
-
220% of activity with formaldehyde
-
-
?
propionaldehyde + H2O + O2
propionic acid + H2O2
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
propionaldehyde + H2O + O2
propionic acid + H2O2
-
ferricyanide and 2,6-dichlorophenol-indophenol as electron acceptor under aerobic conditions
-
-
?
propionaldehyde + H2O + O2
propionic acid + H2O2
-
-
-
-
?
propionaldehyde + H2O + O2
propionic acid + H2O2
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
propionaldehyde + H2O + O2
propionic acid + H2O2
Megalodesulfovibrio gigas
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
propionaldehyde + H2O + O2
propionic acid + H2O2
-
-
-
?
pyridoxal + H2O + O2
4-pyridoxic acid + H2O2
-
-
-
?
quinoline + H2O + electron donor
?
-
ferricyanide as electron donor under aerobic conditions
-
-
?
quinoline + H2O + electron donor
?
-
ferricyanide and cytochrome c as electron donor
-
-
?
retinal + O2 + H2O
retinoate + H2O2
-
involved in vitamin A metabolism, increased activity of cells in hyperthyroidism, decreased activity of cells in hypothyroidism
-
?
retinal + O2 + H2O
retinoate + H2O2
-
activity is dependent on vitamin A levels of tissues
-
?
retinalaldehyde + O2 + H2O
retinoic acid + H2O2
-
-
-
?
salicylaldehyde + H2O + O2
salicylic acid + H2O2
-
ferricyanide as electron acceptor under aerobic conditions
-
-
?
salicylaldehyde + H2O + O2
salicylic acid + H2O2
Megalodesulfovibrio gigas
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
salicylaldehyde + H2O + O2
salicylic acid + H2O2
-
22% of activity with formaldehyde
-
-
?
salicylaldehyde + H2O + O2
salicylic acid + H2O2
-
-
-
?
salicylaldehyde + H2O + O2
salicylic acid + H2O2
-
-
-
?
salicylaldehyde + H2O + O2
salicylic acid + H2O2
-
120% of activity with formaldehyde
-
-
?
salicylaldehyde + H2O + O2
salicylic acid + H2O2
-
8% of activity with n-hexylaldehyde
-
-
?
salicylaldehyde + H2O + O2
salicylic acid + H2O2
-
8% of activity with n-hexylaldehyde
-
-
?
salicylaldehyde + H2O + O2
salicylic acid + H2O2
-
260% of activity with formaldehyde
-
-
?
valerate + H2O2
-
56% of activity with formaldehyde
-
-
?
valeraldehyde + H2O + O2
valerate + H2O2
-
360% of activity with formaldehyde
-
-
?
valeraldehyde + H2O + O2
valerate + H2O2
-
67% of activity with n-hexylaldehyde
-
-
?
valeraldehyde + H2O + O2
valerate + H2O2
-
350% of activity with formaldehyde
-
-
?
valeric acid + H2O2
-
ferricyanide as electron acceptor under aerobic conditions
-
-
?
vanillic acid + H2O2
low AtraAOX2 activity
-
-
?
vanillin + H2O + O2
vanillic acid + H2O2
-
43.3% of the rate with benzaldehyde
-
-
?
vanillin + H2O + O2
vanillic acid + H2O2
-
oxidation of vanillin is more sensitive to inhibition by flavonoids than that of phenanthridine
-
-
?
vanillin + H2O + O2
vanillic acid + H2O2
Q84IX9; Q84IY0 andQ84IX8
-
-
-
?
vanillin + H2O + O2
vanillic acid + H2O2
-
17% of activity with n-hexylaldehyde
-
-
?
veratranoate + H2O2
-
120% of activity with formaldehyde
-
-
?
veratraldehyde + H2O + O2
veratranoate + H2O2
-
220% of activity with formaldehyde
-
-
?
veratraldehyde + H2O + O2
veratranoate + H2O2
-
610% of activity with formaldehyde
-
-
?
uridine + H2O2
-
-
major catabolic route for oral antitumor agent zebularine
-
?
zebularine + H2O + O2
uridine + H2O2
-
-
major catabolic route for oral antitumor agent zebularine
-
?
zebularine + H2O + O2
uridine + H2O2
-
-
major catabolic route for oral antitumor agent zebularine
-
?
zebularine + H2O + O2
uridine + H2O2
-
-
major catabolic route for oral antitumor agent zebularine
-
?
zebularine + H2O + O2
uridine + H2O2
-
-
major catabolic route for oral antitumor agent zebularine
-
?
?
-
AtraAOX2 shows strong activity on aldehyde substrates derived from plants, but weak activity on Z11Z13–16Ald, AtraAOX2 does not degrade the carbamate insecticide aldicarb
-
-
?
additional information
?
-
-
AtraAOX2 shows strong activity on aldehyde substrates derived from plants, but weak activity on Z11Z13–16Ald, AtraAOX2 does not degrade the carbamate insecticide aldicarb
-
-
?
additional information
?
-
enzyme plays an important role in the biotransformation of drugs and xenobiotics, e.g. antiviral, antimalarial and antitumour compounds and nicotine
-
-
?
additional information
?
-
-
enzyme plays an important role in the biotransformation of drugs and xenobiotics, e.g. antiviral, antimalarial and antitumour compounds and nicotine
-
-
?
additional information
?
-
Burkholderia sp. AIU 129
-
no substrates: glycolate and alcohols such as ethanol, 1-propanol, 2-methoxyethanol, ethylene glycol and glycerol
-
-
?
additional information
?
-
low and negligible quinine-oxidizing activity
-
-
?
additional information
?
-
low and negligible quinine-oxidizing activity
-
-
?
additional information
?
-
-
also electron acceptors are dibenzyl sulfoxide, phenothiazine sulfoxide, D-biotin methyl ester d-sulfoxide and quinoline N-oxide
-
-
?
additional information
?
-
-
no substrate: xanthine, allopurinol, isoquinoline
-
-
?
additional information
?
-
-
no substrate: xanthine, allopurinol, isoquinoline
-
-
?
additional information
?
-
enzyme is devoid of xanthine oxidase or hypoxanthine oxidase activity
-
-
?
additional information
?
-
enzyme is devoid of xanthine oxidase or hypoxanthine oxidase activity
-
-
?
additional information
?
-
-
enzyme is devoid of xanthine oxidase or hypoxanthine oxidase activity
-
-
?
additional information
?
-
-
enzyme plays an important role in the biotransformation of drugs and xenobiotics, e.g. antiviral, antimalarial and antitumour compounds and nicotine
-
-
?
additional information
?
-
-
hepatic clearance for substrates of aldehyde oxidase i.e. BIBX1382, carbazeran, O6-benzylguanine, zaleplon, and XK-469 is investigated using cryopreserved hepatocytes
confirmation of aldehyde oxidase mediated metabolism via incubations in the presence of water containing the 18-O isotope and corresponding isotope patterns in mass spectra
-
?
additional information
?
-
-
catalyzes the last step of indole-3-acetic acid biosynthesis. Local synthesis of indole-3-acetic acid in the root nodule meristem and modulation of enzyme expression and activity may be involved in regulation of nodule development
-
-
?
additional information
?
-
-
the enzyme catalyzes the last step of indole-3-acetic acid biosynthesis in plants, in the root nodules. Local synthesis of indole-3-acetic acid in the root nodule meristem and modulation of aldehyde oxidase expression and activity are involved in regulation of nodule development
-
-
?
additional information
?
-
enzyme may be involved in degradation of aldehyde odorant compounds such as pheromones or plantÂ’s volatiles
-
-
?
additional information
?
-
-
enzyme may be involved in degradation of aldehyde odorant compounds such as pheromones or plantÂ’s volatiles
-
-
?
additional information
?
-
-
catalyzes the last step of indole-3-acetic acid biosynthesis. Local synthesis of indole-3-acetic acid in the root nodule meristem and modulation of enzyme expression and activity may be involved in regulation of nodule development
-
-
?
additional information
?
-
-
the enzyme catalyzes the last step of indole-3-acetic acid biosynthesis in plants, in the root nodules. Local synthesis of indole-3-acetic acid in the root nodule meristem and modulation of aldehyde oxidase expression and activity are involved in regulation of nodule development
-
-
?
additional information
?
-
-
enzyme plays an important role in detoxification of the toxic heterocycles synthesized by certain plants
-
-
?
additional information
?
-
Q84IX9; Q84IY0 andQ84IX8
no substrates: xanthine and N'-methylnicotinamide
-
-
-
additional information
?
-
enzyme plays an important role in the biotransformation of drugs and xenobiotics, e.g. antiviral, antimalarial and antitumour compounds and nicotine
-
-
?
additional information
?
-
-
enzyme plays an important role in the biotransformation of drugs and xenobiotics, e.g. antiviral, antimalarial and antitumour compounds and nicotine
-
-
?
additional information
?
-
pyridoxal is not recognized by mouse AOH2
-
-
?
additional information
?
-
pyridoxal is not recognized by mouse AOH2
-
-
?
additional information
?
-
pyridoxal is not recognized by mouse AOH2
-
-
?
additional information
?
-
pyridoxal is not recognized by mouse AOH2
-
-
?
additional information
?
-
no substrate for isoform AOX2: pyridoxal
-
-
-
additional information
?
-
no substrate for isoform AOX2: pyridoxal
-
-
-
additional information
?
-
no substrate for isoform AOX2: pyridoxal
-
-
-
additional information
?
-
no substrate for isoform AOX2: pyridoxal
-
-
-
additional information
?
-
no substrate for isoform AOX3: pyridoxal
-
-
-
additional information
?
-
no substrate for isoform AOX3: pyridoxal
-
-
-
additional information
?
-
no substrate for isoform AOX3: pyridoxal
-
-
-
additional information
?
-
no substrate for isoform AOX3: pyridoxal
-
-
-
additional information
?
-
no substrates for isoform AOX1: N1-methylnicotinamide, pyridoxal
-
-
-
additional information
?
-
no substrates for isoform AOX1: N1-methylnicotinamide, pyridoxal
-
-
-
additional information
?
-
no substrates for isoform AOX1: N1-methylnicotinamide, pyridoxal
-
-
-
additional information
?
-
no substrates for isoform AOX1: N1-methylnicotinamide, pyridoxal
-
-
-
additional information
?
-
-
no substrates for isoform AOX1: N1-methylnicotinamide, pyridoxal
-
-
-
additional information
?
-
no substrates for isoform AOX4: N1-methylnicotinamide, pyridoxal
-
-
-
additional information
?
-
no substrates for isoform AOX4: N1-methylnicotinamide, pyridoxal
-
-
-
additional information
?
-
no substrates for isoform AOX4: N1-methylnicotinamide, pyridoxal
-
-
-
additional information
?
-
no substrates for isoform AOX4: N1-methylnicotinamide, pyridoxal
-
-
-
additional information
?
-
-
no substrates for isoform AOX4: N1-methylnicotinamide, pyridoxal
-
-
-
additional information
?
-
-
electron acceptors are molecular oxygen, several dyes, ferricyanide, silicomolybdate and organic nitro compounds
-
-
?
additional information
?
-
-
various imidazole, pyrazole, pyridine, pyrazine, pyrimidine, purine, quinoline and pteridine derivatives are substrates for this enzyme, preferences of substitutions are discussed
-
-
?
additional information
?
-
-
various unsubstituted aglycones and some ribonucleosides of various purine analogs are also substrates for this enzyme
-
-
?
additional information
?
-
-
enzyme plays an important role in the biotransformation of drugs and xenobiotics, e.g. antiviral, antimalarial and antitumour compounds and nicotine
-
-
?
additional information
?
-
-
isoforms AO-alpha and AO-beta cannot oxidize abscisic aldehyde
-
-
?
additional information
?
-
isoforms AO-alpha and AO-beta cannot oxidize abscisic aldehyde
-
-
?
additional information
?
-
isoforms AO-alpha and AO-beta cannot oxidize abscisic aldehyde
-
-
?
additional information
?
-
isoforms AO-alpha and AO-beta cannot oxidize abscisic aldehyde
-
-
?
additional information
?
-
enzyme oxidizes both sex pheromone compounds as well as plant-derived aldehydes with distinct activities
-
-
-
additional information
?
-
-
enzyme oxidizes both sex pheromone compounds as well as plant-derived aldehydes with distinct activities
-
-
-
additional information
?
-
-
enzyme plays an important role in the biotransformation of drugs and xenobiotics, e.g. antiviral, antimalarial and antitumour compounds and nicotine
-
-
?
additional information
?
-
enzyme plays an important role in the biotransformation of drugs and xenobiotics, e.g. antiviral, antimalarial and antitumour compounds and nicotine
-
-
?
additional information
?
-
enzyme is of interest as a source of the reactive oxygen species, hydrogen peroxide and the superoxide anion
-
-
?
additional information
?
-
-
a wide variety of xenobiotics may serve as electron acceptors instead of molecular oxygen. Enzyme reduces nitroguanidines to both nitroso- and aminoguanidines, while nitromethylens are reduced only to the corrsponding nitroso metabolites. Reduction of nitroguanidines to amino metabolites depends on enzyme concentration
-
-
?
additional information
?
-
-
low and negligible quinine-oxidizing activity
-
-
?
additional information
?
-
low and negligible quinine-oxidizing activity
-
-
?
additional information
?
-
low and negligible quinine-oxidizing activity
-
-
?
additional information
?
-
low and negligible quinine-oxidizing activity
-
-
?
additional information
?
-
low and negligible quinine-oxidizing activity
-
-
?
additional information
?
-
-
phenanthridine N-oxide is not metabolized by the enzyme
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?
additional information
?
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enzyme may be involved in synthesis of reactive oxygen species during water stress
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?
additional information
?
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enzyme produces H2O2, but not O2, and requires a Moco sulfurase domain
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?
additional information
?
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no activities toward N1-methylnicotinamide, quinoline, xanthine, methanol, and ethanol
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?
additional information
?
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no activities toward N1-methylnicotinamide, quinoline, xanthine, methanol, and ethanol
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?
additional information
?
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oxidation of substrates by aldehyde oxidase appears to be due primarily to the electronic effects of the substituents
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?