Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.2.5.1: pyruvate dehydrogenase (quinone)

This is an abbreviated version!
For detailed information about pyruvate dehydrogenase (quinone), go to the full flat file.

Word Map on EC 1.2.5.1

Reaction

pyruvate
+
ubiquinone
+
H2O
=
acetate
+
CO2
+
ubiquinol

Synonyms

EC 1.2.2.2, ECPOX, POX, poxB, POXEC, pqo, pyruvate (quinone) dehydrogenase, pyruvate oxidase, pyruvate oxidase B, pyruvate:quinone oxidoreductase, pyruvate:ubiquinone-8-oxidoreductase, ubiquinione-dependent pyruvate oxidase, ubiquinone-dependent pyruvate oxidase

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.5 With a quinone or similar compound as acceptor
                1.2.5.1 pyruvate dehydrogenase (quinone)

Metals Ions

Metals Ions on EC 1.2.5.1 - pyruvate dehydrogenase (quinone)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
alpha-chymotrypsin
-
20 micromol/ml, wild-type enzyme and the mutant poxB4 are activated 15- and 70fold, respectively, and the mutant poxB3 is activated 14fold
anionic detergents
-
the enzyme activity is stimulated 20- to 50fold, if the enzyme is removed from the membrane particulate fraction of the cell by incubation with a wide variety of amphiphiles
Cationic detergents
-
the enzyme activity is stimulated 20- to 50fold, if the enzyme is removed from the membrane particulate fraction of the cell by incubation with a wide variety of amphiphiles
Mg2+
-
as cofactor
Mn2+
-
divalent metal ion required
SDS
-
20 microM, activates the wild-type and mutant enzymes, poxB3 and poxB4, 15-, 20-, and 70fold, respectively
Triton X-100
-
2.2 mM, activates the wild-type and mutant enzymes, poxB3 and poxB4, 32-, 4-, and 6fold, respectively. With the addition of alpha-chymotrypsin the activation of the mutant enzymes poxB3 and poxB4 is increased 14- and 39fold, respectively
Zwitterionic detergents
-
the enzyme activity is stimulated 20- to 50fold, if the enzyme is removed from the membrane particulate fraction of the cell by incubation with a wide variety of amphiphiles