1.2.7.3: 2-oxoglutarate synthase
This is an abbreviated version!
For detailed information about 2-oxoglutarate synthase, go to the full flat file.
Word Map on EC 1.2.7.3
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1.2.7.3
-
tricarboxylic
-
ferredoxins
-
hydrogen-oxidizing
-
hydrogenobacter
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2-oxoacids
-
pyruvate:ferredoxin
-
ferredoxin-dependent
-
2-oxoacid:ferredoxin
- 1.2.7.3
-
tricarboxylic
- ferredoxins
-
hydrogen-oxidizing
- hydrogenobacter
- 2-oxoacids
-
pyruvate:ferredoxin
-
ferredoxin-dependent
-
2-oxoacid:ferredoxin
Reaction
+ + 2 oxidized ferredoxin = + + 2 reduced ferredoxin + 2 H+
Synonyms
2-ketoglutarate ferredoxin oxidoreductase, 2-oxoglutarate ferredoxin oxidoreductase, 2-oxoglutarate oxidoreductase, 2-oxoglutarate:ferredoxin 2-oxidoreductase (CoA-succinylating), 2-oxoglutarate:ferredoxin oxidoreductase, alpha-ketoglutarate oxidoreductase, alpha-ketoglutarate synthase, alpha-ketoglutarate-ferredoxin oxidoreductase, CoA-dependent 2-ketoglutarate oxidoreductase, EC 1.2.7.9, FOR enzyme, For(OGOR), forDABGE, KGOR, KOR enzyme, Kor(OGOR), Mmc1_1749, Mmc1_1750, OGOR, OOR, oorDABC
ECTree
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Substrates Products
Substrates Products on EC 1.2.7.3 - 2-oxoglutarate synthase
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REACTION DIAGRAM
2-oxoglutarate + CoA + 2 oxidized ferredoxin
succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
2-oxoglutarate + CoA + oxidized ferredoxin
succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
2-oxoglutarate + CoA + oxidized methyl viologen
succinyl-CoA + CO2 + reduced methyl viologen
succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
2-oxoglutarate + CoA + 2 oxidized ferredoxin
succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
2-oxoglutarate + CoA + oxidized ferredoxin
succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
A0L8G4; A0L8G5
-
-
-
r
2-oxoglutarate + CoA + 2 oxidized ferredoxin
succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
A0L8G4; A0L8G5
-
-
-
r
2-oxoglutarate + CoA + 2 oxidized ferredoxin
succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
O87870; Q8RJQ9
specific for 2-oxoglutarate
-
-
?
2-oxoglutarate + CoA + 2 oxidized ferredoxin
succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
-
pure enzyme does not utilize other 2-keto acids, such as pyruvate, phenylglyoxylate, indolepyruvate, 2-oxobutanoate or 2-oxoisovalerate, as substrates
-
-
?
2-oxoglutarate + CoA + 2 oxidized ferredoxin
succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
-
pure enzyme does not utilize other 2-keto acids, such as pyruvate, phenylglyoxylate, indolepyruvate, 2-oxobutanoate or 2-oxoisovalerate, as substrates
-
-
?
succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
-
-
-
-
?
2-oxoglutarate + CoA + oxidized ferredoxin
succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
Q93RA3; Q93RA2, Q9AJM0; Q9AJL9
-
-
-
r
2-oxoglutarate + CoA + oxidized ferredoxin
succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
Hydrogenobacter thermophilus TK-6 / IAM 12695
-
-
-
-
?
2-oxoglutarate + CoA + oxidized ferredoxin
succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
Hydrogenobacter thermophilus TK-6 / IAM 12695
Q93RA3; Q93RA2, Q9AJM0; Q9AJL9
-
-
-
r
succinyl-CoA + CO2 + reduced ferredoxin
D3DIA1; D3DIA2; D3DIA3; D3DIA0; Q93RA0, Q9AJM0; Q9AJL9
-
-
-
?
2-oxoglutarate + CoA + oxidized ferredoxin
succinyl-CoA + CO2 + reduced ferredoxin
D3DIA1; D3DIA2; D3DIA3; D3DIA0; Q93RA0
-
-
-
?
2-oxoglutarate + CoA + oxidized ferredoxin
succinyl-CoA + CO2 + reduced ferredoxin
Q9AJM0; Q9AJL9
involved in carbon dioxide fixation via a reductive TCA cycle
-
-
?
2-oxoglutarate + CoA + oxidized ferredoxin
succinyl-CoA + CO2 + reduced ferredoxin
D3DIA1; D3DIA2; D3DIA3; D3DIA0; Q93RA0
involved in reductive TCA cycle
-
-
?
2-oxoglutarate + CoA + oxidized ferredoxin
succinyl-CoA + CO2 + reduced ferredoxin
D3DIA1; D3DIA2; D3DIA3; D3DIA0; Q93RA0, Q9AJM0; Q9AJL9
one of the key enzymes of the reductive TCA cycle. The physiological function is the reductive carboxylation of succinyl-CoA to produce 2-oxoglutarate, growth under aerobic conditions. Under anaerobic conditions only the Kor enzyme is expressed. The enzyme For supports the optimal growth of the organism in the presence of oxygen
-
-
?
2-oxoglutarate + CoA + oxidized ferredoxin
succinyl-CoA + CO2 + reduced ferredoxin
Q9AJM0; Q9AJL9
activity of the recombinant enzyme with 2-oxobutyrate, 2-oxoisocaproate, 2-oxoisovalerate, oxalacetate, oxomalonate, pyruvate or phosphoenolpyruvate is less than 5% of the activity with 2-oxoglutarate
-
-
?
2-oxoglutarate + CoA + oxidized ferredoxin
succinyl-CoA + CO2 + reduced ferredoxin
-
no activity with oxalacetate, oxomalonate, 2-oxoisocaproate, or phosphoenolpyruvate. The enzyme reacts with 2-oxobutyrate, pyruvate, and 2-oxoisovalerate at an activity level of less than 0.4 to 0.7% relative to that with 2-oxoglutarate. The enzyme uses 2-oxoglutarate, coenzyme A, and one of several electron acceptors in substrate amounts (ferredoxin isolated from Hydrogenobacter thermophilus, flavin adenine dinucleotide, flavin mononucleotide, or methyl viologen). NAD+, NADP+, and ferredoxins from Chlorella spp. and Clostridium pasteurianum are ineffective
-
-
r
2-oxoglutarate + CoA + oxidized ferredoxin
succinyl-CoA + CO2 + reduced ferredoxin
Hydrogenobacter thermophilus TK-6 / IAM 12695
-
no activity with oxalacetate, oxomalonate, 2-oxoisocaproate, or phosphoenolpyruvate. The enzyme reacts with 2-oxobutyrate, pyruvate, and 2-oxoisovalerate at an activity level of less than 0.4 to 0.7% relative to that with 2-oxoglutarate. The enzyme uses 2-oxoglutarate, coenzyme A, and one of several electron acceptors in substrate amounts (ferredoxin isolated from Hydrogenobacter thermophilus, flavin adenine dinucleotide, flavin mononucleotide, or methyl viologen). NAD+, NADP+, and ferredoxins from Chlorella spp. and Clostridium pasteurianum are ineffective
-
-
r
2-oxoglutarate + CoA + oxidized ferredoxin
succinyl-CoA + CO2 + reduced ferredoxin
Hydrogenobacter thermophilus TK-6 / IAM 12695
D3DIA1; D3DIA2; D3DIA3; D3DIA0; Q93RA0
-
-
-
?
2-oxoglutarate + CoA + oxidized ferredoxin
succinyl-CoA + CO2 + reduced ferredoxin
Hydrogenobacter thermophilus TK-6 / IAM 12695
D3DIA1; D3DIA2; D3DIA3; D3DIA0; Q93RA0
involved in reductive TCA cycle
-
-
?
2-oxoglutarate + CoA + oxidized ferredoxin
succinyl-CoA + CO2 + reduced ferredoxin
Hydrogenobacter thermophilus TK-6 / IAM 12695
D3DIA1; D3DIA2; D3DIA3; D3DIA0; Q93RA0, Q9AJM0; Q9AJL9
-
-
-
?
2-oxoglutarate + CoA + oxidized ferredoxin
succinyl-CoA + CO2 + reduced ferredoxin
Hydrogenobacter thermophilus TK-6 / IAM 12695
D3DIA1; D3DIA2; D3DIA3; D3DIA0; Q93RA0, Q9AJM0; Q9AJL9
one of the key enzymes of the reductive TCA cycle. The physiological function is the reductive carboxylation of succinyl-CoA to produce 2-oxoglutarate, growth under aerobic conditions. Under anaerobic conditions only the Kor enzyme is expressed. The enzyme For supports the optimal growth of the organism in the presence of oxygen
-
-
?
2-oxoglutarate + CoA + oxidized ferredoxin
succinyl-CoA + CO2 + reduced ferredoxin
Hydrogenobacter thermophilus TK-6 / IAM 12695
Q9AJM0; Q9AJL9
involved in carbon dioxide fixation via a reductive TCA cycle
-
-
?
2-oxoglutarate + CoA + oxidized ferredoxin
succinyl-CoA + CO2 + reduced ferredoxin
Hydrogenobacter thermophilus TK-6 / IAM 12695
Q9AJM0; Q9AJL9
activity of the recombinant enzyme with 2-oxobutyrate, 2-oxoisocaproate, 2-oxoisovalerate, oxalacetate, oxomalonate, pyruvate or phosphoenolpyruvate is less than 5% of the activity with 2-oxoglutarate
-
-
?
succinyl-CoA + CO2 + reduced ferredoxin + H+
-
-
-
-
?
2-oxoglutarate + CoA + oxidized ferredoxin
succinyl-CoA + CO2 + reduced ferredoxin + H+
Helicobacter pylori DSM 1
-
-
-
-
?
succinyl-CoA + CO2 + reduced methyl viologen
-
-
-
-
?
2-oxoglutarate + CoA + oxidized methyl viologen
succinyl-CoA + CO2 + reduced methyl viologen
Hydrogenobacter thermophilus TK-6 / IAM 12695
-
-
-
-
?
2-oxoglutarate + CoA + oxidized methyl viologen
succinyl-CoA + CO2 + reduced methyl viologen
-
-
-
-
?
2-oxoglutarate + CoA + 2 oxidized ferredoxin
A0L8G4; A0L8G5
-
-
-
?
succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
2-oxoglutarate + CoA + 2 oxidized ferredoxin
A0L8G4; A0L8G5
-
-
-
?
succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
2-oxoglutarate + CoA + 2 oxidized ferredoxin
-
-
-
-
?
succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
2-oxoglutarate + CoA + 2 oxidized ferredoxin
-
may be involved in glutamate synthesis
-
-
?
succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
2-oxoglutarate + CoA + 2 oxidized ferredoxin
-
of several ferredoxins tested, only those from the photosynthetic bacteria Chlorobium thiosulfatophilum, Chromatium, and Rhodospirillum rubrum are effective. The ferredoxins of Clostridium pasteurianum and spinach are poor substitutes for those of photosynthetic bacteria
-
-
r
succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
2-oxoglutarate + CoA + 2 oxidized ferredoxin
-
-
-
-
?
succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
2-oxoglutarate + CoA + 2 oxidized ferredoxin
-
may be involved in glutamate synthesis
-
-
?
succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
2-oxoglutarate + CoA + 2 oxidized ferredoxin
O87870; Q8RJQ9
it is proposed that the enzyme couples the complete acetyl-CoA oxidation to aromatic ring reduction by the use of the low-potential electron shuttle ferredoxin
-
-
?
2-oxoglutarate + CoA + oxidized ferredoxin
-
-
-
-
?
succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
2-oxoglutarate + CoA + oxidized ferredoxin
Q93RA3; Q93RA2, Q9AJM0; Q9AJL9
-
-
-
r
succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
2-oxoglutarate + CoA + oxidized ferredoxin
-
CO2 exchange reaction and CO2 fixation, reductive TCA-cycle
-
-
?
succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
2-oxoglutarate + CoA + oxidized ferredoxin
Q93RA3; Q93RA2, Q9AJM0; Q9AJL9
key enzyme in reductive tricarboxylic acid cycle
-
-
?
succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
2-oxoglutarate + CoA + oxidized ferredoxin
Hydrogenobacter thermophilus TK-6 / IAM 12695
-
-
-
-
?
succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
2-oxoglutarate + CoA + oxidized ferredoxin
Hydrogenobacter thermophilus TK-6 / IAM 12695
-
CO2 exchange reaction and CO2 fixation, reductive TCA-cycle
-
-
?
succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
2-oxoglutarate + CoA + oxidized ferredoxin
Hydrogenobacter thermophilus TK-6 / IAM 12695
Q93RA3; Q93RA2, Q9AJM0; Q9AJL9
-
-
-
r
succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
2-oxoglutarate + CoA + oxidized ferredoxin
Hydrogenobacter thermophilus TK-6 / IAM 12695
Q93RA3; Q93RA2, Q9AJM0; Q9AJL9
key enzyme in reductive tricarboxylic acid cycle
-
-
?
succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
2-oxoglutarate + CoA + oxidized ferredoxin
-
enzyme plays a role in synthesis, not in energy conservation
-
-
?
succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
2-oxoglutarate + CoA + oxidized ferredoxin
-
enzyme plays a role in synthesis, not in energy conservation
-
-
?
2-oxoglutarate + CoA + oxidized ferredoxin
-
-
-
-
r
succinyl-CoA + CO2 + reduced ferredoxin
2-oxoglutarate + CoA + oxidized ferredoxin
-
involved in reductive TCA-cycle
-
-
r
succinyl-CoA + CO2 + reduced ferredoxin
2-oxoglutarate + CoA + oxidized ferredoxin
Hydrogenobacter thermophilus TK-6 / IAM 12695
-
-
-
-
r
succinyl-CoA + CO2 + reduced ferredoxin
2-oxoglutarate + CoA + oxidized ferredoxin
Hydrogenobacter thermophilus TK-6 / IAM 12695
-
involved in reductive TCA-cycle
-
-
r
?
-
A0L8G4; A0L8G5
enzyme is both CO2-fixing and 2-oxoglutarate oxidizing. Negligible activity with other 2-oxoacids, including glyoxylate, pyruvate, 2-oxobutyrate, 2-oxoisovalerate, 3-methyl-2-oxovalerate, phenylpyruvate and oxaloacetate and 2-oxoadipate
-
-
-
additional information
?
-
A0L8G4; A0L8G5
enzyme is both CO2-fixing and 2-oxoglutarate oxidizing. Negligible activity with other 2-oxoacids, including glyoxylate, pyruvate, 2-oxobutyrate, 2-oxoisovalerate, 3-methyl-2-oxovalerate, phenylpyruvate and oxaloacetate and 2-oxoadipate
-
-
-
additional information
?
-
-
enzyme is both CO2-fixing and 2-oxoglutarate oxidizing. Negligible activity with other 2-oxoacids, including glyoxylate, pyruvate, 2-oxobutyrate, 2-oxoisovalerate, 3-methyl-2-oxovalerate, phenylpyruvate and oxaloacetate and 2-oxoadipate
-
-
-