2-oxoglutarate synthase

This is an abbreviated version!
For detailed information about 2-oxoglutarate synthase, go to the full flat file.

Word Map on EC


+ 2 oxidized ferredoxin =
+ 2 reduced ferredoxin + 2 H+


2-ketoglutarate ferredoxin oxidoreductase, 2-oxoglutarate ferredoxin oxidoreductase, 2-oxoglutarate oxidoreductase, 2-oxoglutarate:ferredoxin 2-oxidoreductase (CoA-succinylating), 2-oxoglutarate:ferredoxin oxidoreductase, alpha-ketoglutarate oxidoreductase, alpha-ketoglutarate synthase, alpha-ketoglutarate-ferredoxin oxidoreductase, CoA-dependent 2-ketoglutarate oxidoreductase, FOR enzyme, For(OGOR), forDABGE, KGOR, KOR enzyme, Kor(OGOR), OGOR, OOR, oorDABC


     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.7 With an iron-sulfur protein as acceptor
       2-oxoglutarate synthase

Systematic Name

Systematic Name on EC - 2-oxoglutarate synthase

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IUBMB Comments
2-oxoglutarate:ferredoxin oxidoreductase (decarboxylating)
The enzyme contains thiamine diphosphate and two [4Fe-4S] clusters. Highly specific for 2-oxoglutarate. This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity. For examples of other members of this family, see EC, pyruvate synthase and EC, 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin).