1.3.1.100: chanoclavine-I aldehyde reductase

This is an abbreviated version!
For detailed information about chanoclavine-I aldehyde reductase, go to the full flat file.

Reaction

Synonyms

EasA, FgaOx3, FgaOx3Pr3, old yellow enzyme

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.1 With NAD⁺ or NADP⁺ as acceptor

                1.3.1.100 chanoclavine-I aldehyde reductase

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Results

in table

4

AA Sequence

5

Cloned(Commentary)

11

Cofactor

1

Crystallization (Commentary)

4

General Information

2

KM Value [mM]

2

Molecular Weight [Da]

5

Natural Substrates/ Products (Substrates)

15

Organism

3

Pathway

1

PDB ID

5

Purification (Commentary)

1

Reaction

13

Reference

10

Substrates and Products (Substrate)

4

Subunits

18

Synonyms

1

Systematic Name

1

Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.3.1.100 - chanoclavine-I aldehyde reductase

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SYSTEMATIC NAME

IUBMB Comments

chanoclavine-I aldehyde:NAD+ oxidoreductase

Contains FMN. The enzyme participates in the biosynthesis of fumigaclavine C, an ergot alkaloid produced by some fungi of the Trichocomaceae family. The enzyme catalyses the reduction of chanoclavine-I aldehyde to dihydrochanoclavine-I aldehyde. This hydrolyses spontaneously to form 6,8-dimethyl-6,7-didehydroergoline, which is converted to festuclavine by EC 1.5.1.44, festuclavine dehydrogenase.