1.3.1.108: caffeoyl-CoA reductase
This is an abbreviated version!
For detailed information about caffeoyl-CoA reductase, go to the full flat file.
Word Map on EC 1.3.1.108
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1.3.1.108
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abasic
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anteroposterior
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apurinic
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site-containing
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2-amino-4-phosphonobutyrate
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apyrimidinic
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masker
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acetabular
- 1.3.1.108
-
abasic
-
anteroposterior
-
apurinic
-
site-containing
- 2-amino-4-phosphonobutyrate
-
apyrimidinic
-
masker
-
acetabular
Reaction
+ 2 NAD+ + 2 reduced ferredoxin [iron-sulfur] cluster = + 2 NADH + 2 oxidized ferredoxin [iron-sulfur] cluster
Synonyms
caffeoyl-CoA reductase-Etf complex, electron-bifurcating caffeoyl-CoA reductase, hydrocaffeoyl-CoA:NAD+, ferredoxin oxidoreductase
ECTree
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Cofactor
Cofactor on EC 1.3.1.108 - caffeoyl-CoA reductase
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FAD
the enzyme contains 4 mol of FAD per of enzyme. The CarCDE complex requires FAD for catalytic activity. No activity can be detected when FAD or FMN (0.25 mM) are used alone as electron acceptor, but together with caffeyl-CoA, they are completely reduced with NADH as reductant. Caffeyl-CoA reduction is stimulated by 26- and 12fold with FAD and FMN, respectively. The Km value for both FAD and FMN is 0.1 mM. Thus, caffeyl-CoA and flavins are reduced simultaneously
FMN
no activity can be detected when FAD or FMN (0.25 mM) are used alone as electron acceptor, but together with caffeyl-CoA, they are completely reduced with NADH as reductant. Caffeyl-CoA reduction is stimulated by 26- and 12-fold with FAD and FMN, respectively. The Km value for both FAD and FMN is 0.1 mM. Thus, caffeyl-CoA and flavins are reduced simultaneously
[4Fe-4S]-center
the enzyme contains 2 [4Fe-4S] clusters. It contains 9 mol of iron, and 9 mol of acid-labile sulfur per mol of enzyme