1.3.1.114: 3-dehydro-bile acid DELTA4,6-reductase

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For detailed information about 3-dehydro-bile acid DELTA4,6-reductase, go to the full flat file.

Reaction

Synonyms

BaiN, CLOSCI_00523

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.1 With NAD⁺ or NADP⁺ as acceptor

                1.3.1.114 3-dehydro-bile acid DELTA4,6-reductase

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Results	in table
26	AA Sequence
2	Cloned(Commentary)
2	Cofactor
4	General Information
1	General Stability
13	Natural Substrates/ Products (Substrates)
2	Organism
3	Pathway
1	pH Optimum
1	Purification (Commentary)
4	Reaction
2	Reference
1	Storage Stability
13	Substrates and Products (Substrate)
2	Subunits
6	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 1.3.1.114 - 3-dehydro-bile acid DELTA4,6-reductase

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SYSTEMATIC NAME

IUBMB Comments

3-oxocholan-24-oyl-CoA DELTA4,6-oxidoreductase

Contains flavin. The enzyme, characterized from the bacterium Clostridium scindens, participates in the bile acid 7alpha-dehydroxylation pathway. The enzyme catalyses two subsequent reductions of the double bonds within the bile acid A/B rings, following 7alpha-dehydration.