1.3.1.118: meromycolic acid enoyl-[acyl-carrier-protein] reductase

This is an abbreviated version!
For detailed information about meromycolic acid enoyl-[acyl-carrier-protein] reductase, go to the full flat file.

Word Map on EC 1.3.1.118

1.3.1.118

tuberculosis

mycobacterium

isoniazid

ethionamide

antituberculous

isonicotinic

drug-targeted

pharmacology

fas-ii

antitubercular

Reaction

a meromycolyl-[acyl-carrier protein]

+

NAD⁺

=

a trans-DELTA2-meromycolyl-[acyl-carrier protein]

+

NADH

+

H+

Synonyms

2-trans-enoyl-ACP reductase, 2-trans-enoyl-ACP(CoA) reductase, 2-trans-enoyl-acyl carrier protein reductase, enoyl acyl carrier protein reductase, enoyl acyl carrier protein reductase InhA, enoyl-ACP reductase, enoyl-ACP reductase InhA, enoyl-acyl carrier protein reductase, FAS-II enoyl reductase, FASII enoyl-ACP reductase, InhA, InhA Protein, MtInhA

ECTree

1 Oxidoreductases

1.3 Acting on the CH-CH group of donors

1.3.1 With NAD⁺ or NADP⁺ as acceptor

1.3.1.118 meromycolic acid enoyl-[acyl-carrier-protein] reductase

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Results	in table
2	AA Sequence
5	Application
11	Cloned(Commentary)
10	Cofactor
7	Crystallization (Commentary)
29	General Information
83	IC50 Value
158	Inhibitors
4	kcat/KM [mM/s]
24	Ki Value [mM]
16	KM Value [mM]
2	Molecular Weight [Da]
565	Organism
1	Pathway
4	pH Optimum
2	Posttranslational Modification
38	Protein Variants
10	Purification (Commentary)
1	Reaction
48	Reference
27	Substrates and Products (Substrate)
4	Subunits
57	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
4	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 1.3.1.118 - meromycolic acid enoyl-[acyl-carrier-protein] reductase

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0.0004

(4-(9H-fluoren-9-yl) piperazin-1-yl)-(4-methylbenzyl)-methanone

Mycobacterium tuberculosis

23°C, pH not specified in the publication

0.00157

(4-(9H-fluoren-9-yl)piperazin-1-yl) (2,5-difluorophenyl)methanone

Mycobacterium tuberculosis

pH 7.0, 25°C

0.000361

(4-(9H-fluoren-9-yl)piperazin-1-yl) (2-fluorophenyl)methanone

Mycobacterium tuberculosis

pH 7.0, 25°C

0.00024

(4-(9H-fluoren-9-yl)piperazin-1-yl) (3-fluorophenyl)methanone

Mycobacterium tuberculosis

pH 7.0, 25°C

0.00025

(4-(9H-Fluoren-9-yl)piperazin-1-yl) (3-tolyl)methanone

Mycobacterium tuberculosis

pH 7.0, 25°C

0.00169

(4-(9H-fluoren-9-yl)piperazin-1-yl) (4-chlorophenyl)methanone

Mycobacterium tuberculosis

pH 7.0, 25°C

0.000397

(4-(9H-fluoren-9-yl)piperazin-1-yl) (4-fluorophenyl)methanone

Mycobacterium tuberculosis

pH 7.0, 25°C

0.0029

(4-(9H-fluoren-9-yl)piperazin-1-yl) (4-methoxyphenyl)methanone

Mycobacterium tuberculosis

pH 7.0, 25°C

0.000222

(4-(9H-fluoren-9-yl)piperazin-1-yl) (4-tolyl)methanone

Mycobacterium tuberculosis

pH 7.0, 25°C

0.000183

(4-(9H-fluoren-9-yl)piperazin-1-yl) (phenyl)methanone

Mycobacterium tuberculosis

pH 7.0, 25°C

0.00104

(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-(1H-indole-5-carbonyl)-methanone

Mycobacterium tuberculosis

23°C, pH not specified in the publication

0.00189

(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-(4-methylbenzyl)-methanone

Mycobacterium tuberculosis

23°C, pH not specified in the publication

0.00204

(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-benzyl-methanone

Mycobacterium tuberculosis

23°C, pH not specified in the publication

0.00516

(4-benzylpiperidin-1-yl)(p-tolyl)methanone

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.0034

1-(2-furoyl)-4-[3-(2-ethylphenoxy)benzyl]piperazine

Mycobacterium tuberculosis

-

at pH 6.8 and 25°C

-

0.0078

1-(2-furoyl)-4-[3-(2-methylphenoxy)benzyl]piperazine

Mycobacterium tuberculosis

-

at pH 6.8 and 25°C

-

0.0096

1-(2-furoyl)-4-[3-(phenoxy)benzyl]piperazine

Mycobacterium tuberculosis

-

at pH 6.8 and 25°C

-

0.0022

1-(2-furoyl)-4-[3-[2-(sec-butyl)phenoxy]benzyl]piperazine

Mycobacterium tuberculosis

-

at pH 6.8 and 25°C

-

0.005

1-(2-furoyl)-4-[3-[2-(tert-butyl)phenoxy]benzyl]piperazine

Mycobacterium tuberculosis

-

at pH 6.8 and 25°C

-

0.0018

1-(2-furoyl)-4-[3-[3-(tert-butyl)phenoxy]benzyl]piperazine

Mycobacterium tuberculosis

-

at pH 6.8 and 25°C

-

0.0228

1-(2-furoyl)-4-[3-[3-(trifluoromethyl)phenoxy]benzyl]piperazine

Mycobacterium tuberculosis

-

at pH 6.8 and 25°C

-

26.8

1-(2-furoyl)-4-[3-[4-(methoxycarbonylmethyl)phenoxy]benzyl]piperazine

Mycobacterium tuberculosis

-

at pH 6.8 and 25°C

-

0.00001005

1-cyclohexyl-N-(2,5-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.00039

1-cyclohexyl-N-(3,5-dichlorophenyl)-5-oxopyrrolidine-3-carboxamide

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.00014

1-cyclohexyl-N-(5'-hydroxy-[1,1':4',1''-terphenyl]-2'-yl)-5-oxopyrrolidine-3-carboxamide

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.00004

2-(2-chloro-4-fluorophenyl)-N-(4-((3,5-dimethyl-1H-pyrazol-1-yl)-methyl)phenyl)acetamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.00616

2-(2-methyl-4-oxoquinazolin-3(4H)-yl)-N-(6-nitrobenzo[d]thiazol-2-yl)acetamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.00601

2-(2-methyl-4-oxoquinazolin-3(4H)-yl)-N-(thiophen-2-ylmethyl)acetamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.00892

2-(2-methyl-4-oxoquinazolin-3(4H)-yl)-N-phenylacetamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.00716

2-(6-chloro-2-methyl-4-oxoquinazolin-3(4H)-yl)-N-(2-chloro-5-(trifluoromethyl)phenyl)acetamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.00452

2-(6-chloro-2-methyl-4-oxoquinazolin-3(4H)-yl)-N-(furan-2-ylmethyl)acetamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.00676

2-(6-chloro-2-methyl-4-oxoquinazolin-3(4H)-yl)-N-(thiophen-2-ylmethyl)acetamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.00312

2-(6-chloro-2-methyl-4-oxoquinazolin-3(4H)-yl)-N-phenylacetamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.00456

2-(6-chloro-4-oxoquinazolin-3(4H)-yl)-N-(2-chloro-5-(trifluoromethyl)phenyl)acetamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.00312

2-(6-chloro-4-oxoquinazolin-3(4H)-yl)-N-(furan-2-ylmethyl)acetamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.00712

2-(6-chloro-4-oxoquinazolin-3(4H)-yl)-N-(thiophen-2-ylmethyl)acetamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.00778

2-(6-chloro-4-oxoquinazolin-3(4H)-yl)-N-phenylacetamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.0023

2-(ethanesulfonyl)-6-[2-[(E)-(hydroxyimino)methyl]-4-(trifluoromethyl)phenoxy]-2,3,1-benzodiazaborinin-1(2H)-ol

Mycobacterium tuberculosis

pH 6.8, 23°C

0.00003

2-(ethanesulfonyl)-7-[2-[(Z)-(hydroxyimino)methyl]-4-(trifluoromethyl)phenoxy]-2,3,1-benzodiazaborinin-1(2H)-ol

Mycobacterium tuberculosis

pH 6.8, 23°C

0.0000053 - 0.0000503

2-(o-tolyloxy)-5-hexylphenol

show

0.079

4-[[1-hydroxy-2-(methanesulfonyl)-1,2-dihydro-2,3,1-benzodiazaborinin-7-yl]oxy]benzonitrile

Mycobacterium tuberculosis

pH 6.8, 23°C

0.012

5-[2-[(E)-(hydroxyimino)methyl]phenoxy]-2,1-benzoxaborol-1(3H)-ol

Mycobacterium tuberculosis

pH 6.8, 23°C

0.044

6-[4-(trifluoromethyl)phenoxy]-2,1-benzoxaborol-1(3H)-ol

Mycobacterium tuberculosis

pH 6.8, 23°C

0.0004

7-[2-[(Z)-(hydroxyimino)methyl]-4-(trifluoromethyl)phenoxy]-2-(methanesulfonyl)-2,3,1-benzodiazaborinin-1(2H)-ol

Mycobacterium tuberculosis

pH 6.8, 23°C

0.00016

Genz10850

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.0024

GENZ8575

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.0054

isoniazid

Mycobacterium tuberculosis

-

at pH 6.8 and 25°C

0.00009

N-((4-bromo-1-ethyl-1H-pyrazol-5-yl)methyl)-4-((3,5-dimethyl-1Hpyrazol-1-yl)methyl)benzamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.00054

N-(2-bromobenzyl)-4-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]benzamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.0005

N-(2-chloro-4-fluorobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.00006

N-(2-chloro-4-fluorobenzyl)-4-((4-methylthiazol-2-yl)methyl)-benzamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.00008

N-(2-chloro-5-(2-phenylacetamido)benzyl)-4-((3,5-dimethyl-1Hpyrazol-1-yl)methyl)benzamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.00009

N-(2-chloro-5-(3-phenylureido)benzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.00906

N-(2-chloro-5-(trifluoromethyl)phenyl)-2-(2-methyl-4-oxoquinazolin-3(4H)-yl)acetamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.00816

N-(2-chloro-5-(trifluoromethyl)phenyl)-2-(4-oxoquinazolin-3(4H)-yl)acetamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.00035

N-(2-chloro-5-aminobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.00126

N-(2-chlorobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.00251

N-(2-nitrobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.001

N-(2-trifluorobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)-benzamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.00158

N-(3-bromobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.00158

N-(3-chlorobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.00251

N-(3-methanesulfonybenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)-methyl)benzamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.00158

N-(3-propan-2-yloxybenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.00025

N-(4-fluoro-2-(trifluoromethyl)benzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.0031

N-(4-fluorobenzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.00512

N-(6-nitrobenzo[d]thiazol-2-yl)-2-(4-oxoquinazolin-3(4H)-yl)acetamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.00836

N-(benzo[d]thiazol-2-yl)-2-(6-chloro-2-methyl-4-oxoquinazolin-3(4H)-yl)acetamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.00593

N-(benzyl)-4-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.00686

N-(furan-2-ylmethyl)-2-(2-methyl-4-oxoquinazolin-3(4H)-yl)acetamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.00039

N-([1,1'-biphenyl]-4-yl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.00009 - 0.00325

N-[(2-chloro-4-fluorophenyl)methyl]-4-[(2-methyl-1,3-thiazol-4-yl)methyl]benzamide

show

0.0005

N-[(2-chloro-4-fluorophenyl)methyl]-4-[(3-methyl-1H-pyrazol-1-yl)methyl]benzamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.0034

N-[(2-chloro-4-fluorophenyl)methyl]-4-[(6-methylpyridin-2-yl)-oxy]benzamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.00005

N-[(2-chloro-4-fluorophenyl)methyl]-4-[(6-methylpyridin-2-yl)methyl]benzamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.00006

N-[(2-chloro-4-fluorophenyl)methyl]-4-[(6-methylpyridin-2-yl)sulfanyl]benzamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.0014

N-[(2-chloro-4-fluorophenyl)methyl]-4-[(dimethyl-1,3-thiazol-2-yl)methyl]benzamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.00032

N-[(2-chloro-4-fluorophenyl)methyl]-4-[2-(3,5-dimethyl-1H-pyrazol-1-yl)ethyl]benzamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.00012

N-[(4-fluorophenyl)methyl]-4-[[2-methyl-5-(2,2,2-trifluoroethyl)furan-3-yl]methyl]benzamide

Mycobacterium tuberculosis

pH 6.8, 25°C

0.00009

[4-(9H-fluoren-9-yl) piperazin-1-yl]-benzyl-methanone

Mycobacterium tuberculosis

23°C, pH not specified in the publication

0.0002

[4-(9H-fluoren-9-yl)piperazin-1-yl](1H-indol-5-yl)methanone

Mycobacterium tuberculosis

23°C, pH not specified in the publication

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Release 2023.1 (January 2023)