1.3.1.118: meromycolic acid enoyl-[acyl-carrier-protein] reductase

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For detailed information about meromycolic acid enoyl-[acyl-carrier-protein] reductase, go to the full flat file.

Word Map on EC 1.3.1.118

1.3.1.118

tuberculosis

mycobacterium

isoniazid

ethionamide

antituberculous

isonicotinic

drug-targeted

pharmacology

fas-ii

antitubercular

Reaction

a trans-DELTA2-meromycolyl-[acyl-carrier protein]

Synonyms

2-trans-enoyl-ACP reductase, 2-trans-enoyl-ACP(CoA) reductase, 2-trans-enoyl-acyl carrier protein reductase, enoyl acyl carrier protein reductase, enoyl acyl carrier protein reductase InhA, enoyl-ACP reductase, enoyl-ACP reductase InhA, enoyl-acyl carrier protein reductase, FAS-II enoyl reductase, FASII enoyl-ACP reductase, InhA, InhA Protein, MtInhA

ECTree

1 Oxidoreductases

1.3 Acting on the CH-CH group of donors

1.3.1 With NAD⁺ or NADP⁺ as acceptor

1.3.1.118 meromycolic acid enoyl-[acyl-carrier-protein] reductase

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Results	in table
2	AA Sequence
5	Application
11	Cloned(Commentary)
10	Cofactor
7	Crystallization (Commentary)
29	General Information
83	IC50 Value
158	Inhibitors
4	kcat/KM [mM/s]
24	Ki Value [mM]
16	KM Value [mM]
2	Molecular Weight [Da]
565	Organism
1	Pathway
4	pH Optimum
2	Posttranslational Modification
38	Protein Variants
10	Purification (Commentary)
1	Reaction
48	Reference
27	Substrates and Products (Substrate)
4	Subunits
57	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
4	Turnover Number [1/s]

KM Value

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KM Value on EC 1.3.1.118 - meromycolic acid enoyl-[acyl-carrier-protein] reductase

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0.0045 - 0.065

NADH

6 entries

0.0196 - 0.0523

trans-2-dodecenoyl-CoA

5 entries

0.0015

trans-2-hexadecenoyl-CoA

Mycobacterium tuberculosis

P9WGR1

pH 6.8, 25°C, wild-type enzyme

747053

0.467 - 0.688

trans-2-octenoyl-CoA

2 entries

0.002 - 0.0027

trans-2-octenoyl-[acyl-carrier protein]

2 entries