1.3.1.2: dihydropyrimidine dehydrogenase (NADP+)

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For detailed information about dihydropyrimidine dehydrogenase (NADP+), go to the full flat file.

Reaction

Synonyms

4,5-dihydrothymine: oxidoreductase, dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide phosphate), DHPDH, DHPDHase, DHU dehydrogenase, dihydropyrimidine dehydrogenase, dihydrothymine dehydrogenase, Dihydrouracil dehydrogenase, dihydrouracil dehydrogenase (NADP), dihydrouracil dehydrogenase (NADP+), DPD, DPYD, hydropyrimidine dehydrogenase

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.1 With NAD⁺ or NADP⁺ as acceptor

                1.3.1.2 dihydropyrimidine dehydrogenase (NADP+)

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Results	in table
5	Activating Compound
2252	AA Sequence
13	Application
1	CAS Registry Number
8	Cloned(Commentary)
70	Cofactor
4	Crystallization (Commentary)
42	Disease/ Diagnostics
5	General Information
9	General Stability
6	IC50 Value
79	Inhibitors
19	kcat/KM [mM/s]
21	Ki Value [mM]
74	KM Value [mM]
19	Localization
11	Metals/Ions
21	Molecular Weight [Da]
50	Natural Substrates/ Products (Substrates)
57	Organism
11	Pathway
40	PDB ID
8	pH Optimum
2	pH Range
1	pH Stability
20	Protein Variants
23	Purification (Commentary)
7	Reaction
3	Reaction Type
57	Reference
51	Source Tissue
27	Specific Activity [micromol/min/mg]
4	Storage Stability
146	Substrates and Products (Substrate)
11	Subunits
29	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
1	Temperature Stability [°C]
17	Turnover Number [1/s]

Crystallization

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Crystallization on EC 1.3.1.2 - dihydropyrimidine dehydrogenase (NADP+)

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

cocrystallization with 5-iodouracil 1 mM and NADPH 5 mM, ternary complex in 100 mM HEPES, pH 7.5, 22% polyethylene glycol 6000, uracil-4-acetic acid 1 mM, structure determination at different pH-values

Sus scrofa

-

349233

crystals diffract to 1.9 A

Sus scrofa

-

654897

mutant C671S, to 1.69 A resolution. The thymine substrate is positioned over the FMNH2 cofactor with the 6-methyne carbon 3.3 A from flavin N5

Sus scrofa

Q28943

762737

mutants E244V and A551T

Sus scrofa

-

672471