1.3.1.2: dihydropyrimidine dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about dihydropyrimidine dehydrogenase (NADP+), go to the full flat file.

Word Map on EC 1.3.1.2

1.3.1.2

5-fluorouracil

thymidine

phosphorylase

uridine

medicine

phosphoribosyltransferase

orotate

2.4.2.4

thymidylate

fluoropyrimidine

fdurd

2.7.1.21

beta-ureidopropionase

urdpase

dihydropyrimidinase

beta-alanine

drug development

analysis

Reaction

Synonyms

4,5-dihydrothymine: oxidoreductase, dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide phosphate), DHPDH, DHPDHase, DHU dehydrogenase, dihydropyrimidine dehydrogenase, dihydrothymine dehydrogenase, Dihydrouracil dehydrogenase, dihydrouracil dehydrogenase (NADP), dihydrouracil dehydrogenase (NADP+), DPD, DPYD, hydropyrimidine dehydrogenase

ECTree

1 Oxidoreductases

1.3 Acting on the CH-CH group of donors

1.3.1 With NAD⁺ or NADP⁺ as acceptor

1.3.1.2 dihydropyrimidine dehydrogenase (NADP+)

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Results	in table
5	Activating Compound
2252	AA Sequence
13	Application
1	CAS Registry Number
8	Cloned(Commentary)
70	Cofactor
4	Crystallization (Commentary)
42	Disease/ Diagnostics
5	General Information
9	General Stability
6	IC50 Value
79	Inhibitors
19	kcat/KM [mM/s]
21	Ki Value [mM]
74	KM Value [mM]
19	Localization
11	Metals/Ions
21	Molecular Weight [Da]
50	Natural Substrates/ Products (Substrates)
57	Organism
11	Pathway
40	PDB ID
8	pH Optimum
2	pH Range
1	pH Stability
20	Protein Variants
23	Purification (Commentary)
7	Reaction
3	Reaction Type
57	Reference
51	Source Tissue
27	Specific Activity [micromol/min/mg]
4	Storage Stability
146	Substrates and Products (Substrate)
11	Subunits
29	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
1	Temperature Stability [°C]
17	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 1.3.1.2 - dihydropyrimidine dehydrogenase (NADP+)

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5,6-dihydrouracil + NADP+

uracil + NADPH

8 entries

5,6-dihydrouracil + NADP+

uracil + NADPH + H+

Homo sapiens

740412

5-fluorouracil + NADPH + H+

5-fluoro-5,6-dihydrouracil + NADP+

4 entries

dihydrofluorouracil + NADP+

5-fluorouracil + NADPH + H+

2 entries

dihydrothymine + NADP+

thymine + NADPH + H+

Sus scrofa

Q28943

711309

dihydrouracil + NADP+

uracil + NADPH + H+

Sus scrofa

Q28943

711309

thymine + NADPH

dihydrothymine + NADP+

15 entries

uracil + NADPH

5,6-dihydrouracil + NADP+

16 entries

uracil + NADPH + H+

5,6-dihydrouracil + NADP+

2 entries